Patents by Inventor Leonard Bruce Crast, Jr.

Leonard Bruce Crast, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of p-hydroxycephalexin
    Patent number: 3985741
    Abstract: Improved yields of 7-[D-.alpha.-amino-.alpha.-(4-hydroxy- and 3-chloro-4-hydroxy-phenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acids are obtained by acylating 7-aminodesacetoxycephalosporanic acid with the mixed anhydride (from ethyl chloroformate) of the ring-substituted 2-phenylglycine when the latter's .alpha.-amino group has been blocked by reaction with a .beta.-keto compound such as methyl acetoacetate. Improved purification processes include the use of dimethylformamide and acetonitrile solvates and solvates and bis-anthraquinone-1,5-disulfonic acid salts.
    Type: Grant
    Filed: October 18, 1974
    Date of Patent: October 12, 1976
    Assignee: Bristol-Myers Company
    Inventors: Leonard Bruce Crast, Jr., William Joseph Gottstein
  • 7-Amino-cephalosporanic and decephalosporanic acid derivatives
    Patent number: RE29164
    Abstract: 7[D-(-)-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido]-cephalosporanic acid and 7-D-(-)-2,2-dimethyl-4-(p-hydroxyphenyl)-5-oxo-1-imidazolidinyl]cephalospo ranic acid and the corresponding decephalosporanic acids and the salts thereof are new synthetic compounds of value as antibacterial agents and in the treatment of bacterial infections.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: March 29, 1977
    Assignee: Bristol-Myers Company
    Inventor: Leonard Bruce Crast, Jr.