Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.

Abstract: A method for bowling a ball typically in ten pin bowling using apparatus (10) in which a ball (15) is supported to movable support means typically a roller (23) which is rotatably driven by a motor (26) whilst the ball is restrained in a substantially fixed position with the apparatus (10) including a stop (29) which may be actuated to release the rotating ball (15) to allow said ball to travel in a desired direction of travel along an elongated guide member or barrel (11).

Abstract: A method for bowling a ball typically in ten pin bowling using apparatus (10) in which a ball (15) is supported to movable support means typically a roller (23) which is rotatably driven by a motor (26) whilst the ball is restrained in a substantially fixed position with the apparatus (10) including a stop (29) which may be actuated to release the rotating ball (15) to allow said ball to travel in a desired direction of travel along an elongated guide member or barrel (11).

Abstract: A coating having an adhesive hydrophilic polymer and an amphiphilic additive. The amphiphilic additive has a hydrophilic chain, a biocidal functional group bonded to the hydrophilic chain, and a hydrophobic moiety bonded to the hydrophilic chain or to the biocidal functional group. A method of forming a biocidal surface by providing an article, and coating the article with the above coating.

Abstract: A coating having an adhesive hydrophilic polymer and an amphiphilic additive. The amphiphilic additive has a hydrophilic chain, a biocidal functional group bonded to the hydrophilic chain, and a hydrophobic moiety bonded to the hydrophilic chain or to the biocidal functional group. A method of forming a biocidal surface by providing an article, and coating the article with the above coating. A compound having the formula: Y—(O—Ch2—Ch2)n—R—(CH2)m—CH3. Y is CH3 or H. R is X is a halogen, and m and n are independently selected positive integers.

Abstract: A golf club carrier (10) including an outer elongated cylindrical shell (11), a storage unit (20) having storage compartements (21) supported for rotation about a longitudinal axis within the shell (11) and means (24) for supporting a plurality of golf clubs (23) at spaced circumferential positions around the storage unit (20). The cylindrical shell (11) has a side opening (12) and the unit may be rotated to align the compartments (21) with the opening (12) to allow acess thereto or rotated to allow access to clubs (23) supported around the storage unit (20).