Patents by Inventor Leonard Estis

Leonard Estis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070077621
    Abstract: Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene denV, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the active proteins can be used in, for example, topical formulations for treatment of photosensitive diseases. Stream mixing can also be used to solubilize inclusion bodies containing proteins other than CPD glycosylases.
    Type: Application
    Filed: June 29, 2006
    Publication date: April 5, 2007
    Applicant: Applied Genetics Incorporated Dermatics
    Inventors: Daniel Yarosh, Leonard Estis, Eliyahu Kraus
  • Patent number: 6090406
    Abstract: A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein said liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen wherein said organic acid derivative of a sterol and immunogen are present in an immunization dose, and method according to use is disclosed.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: July 18, 2000
    Assignee: The Liposome Company, Inc.
    Inventors: Mircea C. Popescu, Alan L. Weiner, Marie S. Recine, Andrew S. Janoff, Leonard Estis, Lynn D. Keyes, Carl R. Alving
  • Patent number: 5916588
    Abstract: A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with the liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use.Immunizing dosage forms comprising a liposome and an immunogen, wherein the liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen are present in an immunization dose, and method according to uses is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristolyphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein the DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: June 29, 1999
    Assignee: The Liposome Company, Inc.
    Inventors: Mircea C. Popescu, Alan L. Weiner, Marie S. Recine, Andrew S. Janoff, Leonard Estis, Lynn D. Keyes, Carl R. Alving
  • Patent number: 5026557
    Abstract: An adjuvant composition comprising a small liposome with incubation associated immuno-potentiator such as Lipid A, said composition with incubation associated antigen, and method of preparation and use.
    Type: Grant
    Filed: February 14, 1990
    Date of Patent: June 25, 1991
    Assignee: The Liposome Company, Inc.
    Inventors: Leonard Estis, Phillip Livingston