Abstract: There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.

Abstract: Cefuroxime axetil in particulate form is coated with an integral coating of a lipid or mixture of lipids which serves to mask the bitter taste of cefuroxime axetil but disperses or dissolves on contact with gastrointestinal fluid. The resulting particles may be incorporated into pharmaceutical compositions for oral administration, for instance aqueous suspensions.

Abstract: There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.

Abstract: Liquid additives can be supplied to a fermenter vessel from a reservoir by a dispensing device which comprises a central discharge chamber connected in series between an upper escape chamber and a lower inlet chamber. These chambers are arranged to provide a smooth passage for liquid and do not have any steps or recesses therein. An escape port leading from the upper end of the escape chamber to the reservoir is controlled by a valve member. An inlet port leads into the lower end of the inlet chamber from the reservoir and is controlled by a valve member. A discharge port leads from the bottom end of the discharge chamber and is controlled by a valve member. A pressure equalizing port leads to the top end of the discharge chamber and is controlled by a valve member. The discharge and pressure equalizing ports are connected to the upper portion of the fermenter vessel. The escape chamber is capable of retaining liquid therein by interfacial tension while liquid is discharged from the discharge chamber.