Patents by Inventor Leonard G. Presta

Leonard G. Presta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE-CHAIN TNF RECEPTOR 2 AGONIST FUSION PROTEINS
    Publication number: 20200369739
    Abstract: This invention provides for a fusion protein between a single chain TNFR2 Selective Agonist protein (scTNFR2 Selective Agonist) and a dimerization domain, such as an IgGFc protein. The single chain TNFR2 Selective Agonist moiety provides a therapeutic activity by selectively activating the TNFR2 form of the TNF-? receptor, thus selectively stimulating Tregs and/or increasing myelin deposition.
    Type: Application
    Filed: June 5, 2018
    Publication date: November 26, 2020
    Applicant: Relinia, Inc.
    Inventors: David C Foster, Lutz B Giebel, Leonard G Presta
  • Anti-TREM1 antibodies and related methods
    Patent number: 10836828
    Abstract: Provided herein are anti-TREM1 antibodies and related methods of making and using anti-TREM1 antibodies. Also provided are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an anti-TREM1 antibody or antigen binding fragment thereof.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: November 17, 2020
    Assignee: PIONYR IMMUNOTHERAPEUTICS, INC.
    Inventors: Christopher Chan, Aritra Pal, Venkataraman Sriram, Leonard G. Presta, Tiep Tu Le, Linda Liang
  • Anti-C10ORF54 antibodies and uses thereof
    Patent number: 10766959
    Abstract: The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: September 8, 2020
    Assignee: Pierre Fabre Medicament
    Inventors: John Lippincott, Edward Thein Htun Van Der Horst, Sung Young Kim, Leonard G Presta, Jan-Willem Theunissen
  • ANTI-TM4SF1 ANTIBODIES AND METHODS OF USING SAME
    Publication number: 20200270360
    Abstract: Anti-TM4SF1 antibodies, and antigen-binding fragments thereof, are described that bind to an epitope on the ECL2 loop of human TM4SF1. Methods of use of said antibodies and fragments are also described, including for the inhibition of metastasis.
    Type: Application
    Filed: August 28, 2018
    Publication date: August 27, 2020
    Inventors: Paul A. Jaminet, Shou-Ching S. Jaminet, Harold F. Dvorak, Leonard G. Presta
  • BINDING MOLECULES WITH MODIFIED J-CHAIN
    Publication number: 20200255546
    Abstract: The present invention concerns binding molecules that comprise an IgM, IgA, IgG/IgM or IgG/IgA antibody with a J-chain modified to include an ADME-modulating moiety, and their uses.
    Type: Application
    Filed: January 16, 2020
    Publication date: August 13, 2020
    Inventors: Bruce A. Keyt, Leonard G. Presta, Ramesh Baliga
  • ANTI-TREM1 ANTIBODIES AND RELATED METHODS
    Publication number: 20200255529
    Abstract: Provided herein are anti-TREM1 antibodies and related methods of making and using anti-TREM1 antibodies. Also provided are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an anti-TREM1 antibody or antigen binding fragment thereof.
    Type: Application
    Filed: April 17, 2020
    Publication date: August 13, 2020
    Inventors: Christopher CHAN, Aritra PAL, Venkataraman SRIRAM, Leonard G. PRESTA, Tiep Tu LE, Linda LIANG
  • ANTI-TREM2 ANTIBODIES AND RELATED METHODS
    Publication number: 20200140546
    Abstract: Provided herein are anti-TREM2 antibodies and related methods of making and using anti-TREM2 antibodies. Also provided are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an anti-TREM2 antibody or antigen binding fragment thereof.
    Type: Application
    Filed: October 14, 2019
    Publication date: May 7, 2020
    Inventors: Michel Streuli, Venkataraman Sriram, Aritra Pal, Leonard G. Presta
  • Binding molecules with modified J-chain
    Patent number: 10618978
    Abstract: The present invention concerns binding molecules that comprise an IgM, IgA, IgG/IgM or IgG/IgA antibody with a J-chain modified to include an AD-ME-modulating moiety, and their uses.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: April 14, 2020
    Assignee: IGM Biosciences, Inc.
    Inventors: Bruce A. Keyt, Leonard G. Presta, Ramesh Baliga
  • Anti-CD39 antibodies and uses thereof
    Patent number: 10556959
    Abstract: The present disclosure relates generally to anti-CD39 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: February 11, 2020
    Assignee: Xencor, Inc.
    Inventors: Guoqing Chen, Gregory M. Hayes, Jan-Willem Theunissen, Edward Thein H. Van Der Horst, Leonard G. Presta
  • ANTI-C10ORF54 ANTIBODIES AND USES THEREOF
    Publication number: 20200040102
    Abstract: The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
    Type: Application
    Filed: July 23, 2019
    Publication date: February 6, 2020
    Applicant: Pierre Fabre Medicament
    Inventors: John LIPPINCOTT, Edward Thein Htun VAN DER HORST, Sun Young KIM, Leonard G. PRESTA
  • Anti-TREM2 antibodies and related methods
    Patent number: 10508148
    Abstract: Provided herein are anti-TREM2 antibodies and related methods of making and using anti-TREM2 antibodies. Also provided are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an anti-TREM2 antibody or antigen binding fragment thereof.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: December 17, 2019
    Assignee: Pionyr Immunotherapeutics, Inc.
    Inventors: Michel Streuli, Venkataraman Sriram, Aritra Pal, Leonard G. Presta
  • Antigen-Binding Polypeptide Constructs Comprising Kappa and Lambda Light Chains and Uses Thereof
    Publication number: 20190338048
    Abstract: Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain. At least one heterodimer comprises a Fab region comprising a lambda light chain and at least one heterodimer comprises a Fab region comprising a kappa light chain. One or more of the immunoglobulin heavy and light chains that form the antigen-binding polypeptide construct comprise amino acid modifications that promote correct pairing between the heavy and light chains to form the desired multispecific antigen-binding polypeptide construct. The amino acid modifications may be in the CH1 and/or CL domains, in the VH and/or VL domains, or a combination thereof.
    Type: Application
    Filed: October 7, 2016
    Publication date: November 7, 2019
    Inventors: Dunja UROSEV, Stacy A.L. TOM-YEW, Leonard G. PRESTA, Mario SANCHES
  • ANTI-IL1-RAP ANTIBODIES
    Publication number: 20190338038
    Abstract: Provided herein are antibodies specific for IL1-RAP.
    Type: Application
    Filed: October 16, 2017
    Publication date: November 7, 2019
    Applicant: Cellerant Therapeutics, Inc.
    Inventors: Ying Ping Jiang, Jagath R. Junutula, Leonard G. Presta
  • ANTI-TREM2 ANTIBODIES AND RELATED METHODS
    Publication number: 20190309064
    Abstract: Provided herein are anti-TREM2 antibodies and related methods of making and using anti-TREM2 antibodies. Also provided are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an anti-TREM2 antibody or antigen binding fragment thereof.
    Type: Application
    Filed: May 9, 2019
    Publication date: October 10, 2019
    Inventors: Michel Streuli, Venkataraman Sriram, Aritra Pal, Leonard G. Presta
  • Anti-C10orf54 antibodies and uses thereof
    Patent number: 10421818
    Abstract: The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: September 24, 2019
    Assignee: PIERRE FABRE MEDICAMENT
    Inventors: John Lippincott, Edward Thein Htun Van Der Horst, Sun Young Kim, Leonard G. Presta
  • Anti-C10orf54 antibodies and uses thereof
    Patent number: 10414823
    Abstract: The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: September 17, 2019
    Assignee: PIERRE FABRE MEDICAMENT
    Inventors: John Lippincott, Edward Thein Htun Van Der Horst, Sun Young Kim, Leonard G. Presta
  • Anti-GITR antibodies
    Patent number: 10400040
    Abstract: Antibodies to human GITR are provided, as well as uses thereof, e.g., in treatment of proliferative and immune disorders.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: September 3, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Xiao Min Schebye, Grigori P. Ermakov, Douglas J. Hodges, Leonard G. Presta
  • ANTI-C10ORF54 ANTIBODIES AND USES THEREOF
    Publication number: 20190177415
    Abstract: The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
    Type: Application
    Filed: December 11, 2015
    Publication date: June 13, 2019
    Inventors: John LIPPINCOTT, Edward Thein Htun VAN DER HORST, Sung Young KIM, Leonard G PRESTA, Jan-Willem THEUNISSEN
  • IMMUNOGLOBULIN VARIANTS AND USES THEREOF
    Publication number: 20190071511
    Abstract: The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
    Type: Application
    Filed: February 26, 2018
    Publication date: March 7, 2019
    Applicant: Genentech, Inc.
    Inventors: Camellia W. ADAMS, Andrew C. CHAN, Craig W. CROWLEY, Henry B. LOWMAN, Gerald R. NAKAMURA, Leonard G. PRESTA
  • ANTI-C10ORF54 ANTIBODIES AND USES THEREOF
    Publication number: 20190031768
    Abstract: The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
    Type: Application
    Filed: August 2, 2018
    Publication date: January 31, 2019
    Inventors: John LIPPINCOTT, Edward Thein Htun VAN DER HORST, Sun Young KIM, Leonard G. PRESTA