Patents by Inventor Leonard George Presta

Leonard George Presta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-PD-L1 ANTIBODIES
    Publication number: 20240002514
    Abstract: Aspects of the invention include isolated anti-PD-L1 antibodies, as well as compositions containing such antibodies, and methods of using the same in the treatment of diseases or conditions that are mediated by PD-L1 signaling.
    Type: Application
    Filed: September 7, 2023
    Publication date: January 4, 2024
    Inventors: Bruce KEYT, Leonard George PRESTA, Ramesh BALIGA
  • MODIFIED J-CHAIN
    Publication number: 20230279111
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Application
    Filed: November 3, 2022
    Publication date: September 7, 2023
    Inventors: Bruce KEYT, Leonard George PRESTA, Fen ZHANG, Ramesh BALIGA
  • Modified J-chain
    Patent number: 11555075
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: January 17, 2023
    Assignee: IGM Biosciences, Inc.
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • CD25 Antibodies
    Publication number: 20220153852
    Abstract: Provided herein are humanized CD25 antibodies, methods of making, and use thereof. In some embodiments, the CD25 antibodies are useful for the treatment of cancer or autoimmune diseases.
    Type: Application
    Filed: November 12, 2021
    Publication date: May 19, 2022
    Inventors: Ramesh Baliga, Leonard George Presta, Phung Tu Gip, Hanako Daino-Laizure, Piotr J. Zalicki, Oleg Gurinovich
  • ANTI-PD-L1 ANTIBODIES
    Publication number: 20210163600
    Abstract: Aspects of the invention include isolated anti-PD-L1 antibodies, as well as compositions containing such antibodies, and methods of using the same in the treatment of diseases or conditions that are mediated by PD-L1 signaling.
    Type: Application
    Filed: February 10, 2021
    Publication date: June 3, 2021
    Inventors: Bruce KEYT, Leonard George PRESTA, Ramesh BALIGA
  • Modified J-chain
    Patent number: 10975147
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: April 13, 2021
    Assignee: IGM Biosciences, Inc.
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • Anti-PD-L1 antibodies
    Patent number: 10954302
    Abstract: Aspects of the invention include isolated anti-PD-L1 antibodies, as well as compositions containing such antibodies, and methods of using the same in the treatment of diseases or conditions that are mediated by PD-L1 signaling.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: March 23, 2021
    Assignee: IGM Biosciences, Inc.
    Inventors: Bruce Keyt, Leonard George Presta, Ramesh Baliga
  • IgA multi-specific binding molecules
    Patent number: 10822399
    Abstract: The present invention concerns IgA multi-specific binding molecules. In particular, the invention concerns multi-specific, including bispecific, binding molecules comprising IgA heavy chain sequences, and methods for their preparation and use.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: November 3, 2020
    Assignee: IGM Biosciences, Inc.
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Stephen F. Carroll
  • MODIFIED J-CHAIN
    Publication number: 20200190190
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Application
    Filed: February 27, 2020
    Publication date: June 18, 2020
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • ANTI-PD-L1 ANTIBODIES
    Publication number: 20190338031
    Abstract: Aspects of the invention include isolated anti-PD-L1 antibodies, as well as compositions containing such antibodies, and methods of using the same in the treatment of diseases or conditions that are mediated by PD-L1 signaling.
    Type: Application
    Filed: May 9, 2017
    Publication date: November 7, 2019
    Inventors: Bruce KEYT, Leonard George PRESTA, Ramesh BALIGA
  • Modified J-chain
    Patent number: 10400038
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: September 3, 2019
    Assignee: IGM Biosciences, Inc.
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • Constant chain modified bispecific, penta- and hexavalent Ig-M antibodies
    Patent number: 10351631
    Abstract: The present invention concerns binding molecules having a penta- or hexameric ring structure, such as, for example, isolated IgM antibodies with five or six bispecific binding units, and methods and means for making and using the same. The invention further concerns multi-specific binding molecules having a penta- or hexameric ring structure, such as, for example, isolated IgM antibodies with five or six bispecific binding units, and methods and means for making and using the same.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: July 16, 2019
    Assignee: IGM BIOSCIENCES, INC.
    Inventors: Bruce Alan Keyt, Fen Zhang, Leonard George Presta, Rency Yoshimura
  • BINDING MOLECULES WITH MODIFIED J-CHAIN
    Publication number: 20190185570
    Abstract: The present invention provides binding molecules that include an IgM, IgA, IgG/IgM or IgG/IgA antibody with a modified J-chain that includes a binding moiety that antagonizes a T-cell inhibitory signaling pathway, and their uses.
    Type: Application
    Filed: September 30, 2016
    Publication date: June 20, 2019
    Inventors: Bruce A. Keyt, Leonard George Presta, Ramesh Baliga
  • MODIFIED J-CHAIN
    Publication number: 20190002566
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Application
    Filed: September 19, 2018
    Publication date: January 3, 2019
    Inventors: Bruce Alan Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • BINDING MOLECULES WITH MODIFIED J-CHAIN
    Publication number: 20180265596
    Abstract: The present invention concerns binding molecules that comprise an IgM, IgA, IgG/IgM or IgG/IgA antibody with a J-chain modified to include an AD-ME-modulating moiety, and their uses.
    Type: Application
    Filed: September 30, 2016
    Publication date: September 20, 2018
    Inventors: Bruce A. Keyt, Leonard George Presta, Ramesh Baliga
  • Modified J-chain
    Patent number: 9951134
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies, comprising the same, and their uses.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: April 24, 2018
    Assignee: IGM BIOSCIENCES A/S
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • MODIFIED J-CHAIN
    Publication number: 20170283510
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Application
    Filed: April 2, 2015
    Publication date: October 5, 2017
    Inventors: Bruce KEYT, Leonard George PRESTA, Fen ZHANG, Ramesh BALIGA
  • MODIFIED J-CHAIN
    Publication number: 20170183409
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies, comprising the same, and their uses.
    Type: Application
    Filed: March 7, 2017
    Publication date: June 29, 2017
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • IGA MULTI-SPECIFIC BINDING MOLECULES
    Publication number: 20160368971
    Abstract: The present invention concerns IgA multi-specific binding molecules. In particular, the invention concerns multi-specific, including bispecific, binding molecules comprising IgA heavy chain sequences, and methods for their preparation and use.
    Type: Application
    Filed: February 10, 2015
    Publication date: December 22, 2016
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Stephen F. Carroll