Patents by Inventor Leonard H. Rome

Leonard H. Rome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vault complexes for cytokine delivery
    Patent number: 11793860
    Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: October 24, 2023
    Assignees: The Regents of the University of California, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Leonard H. Rome, Valerie Ann Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
  • Sol-Gel Vaults and Methods of Making and Using Thereof
    Publication number: 20220105199
    Abstract: A sol-gel vault which comprises a complex between a vault particle and a sol-gel. The vault particle comprises one or more one or more passenger molecules. At least one of the one or more passenger molecules is an mINT passenger molecule. At least one of the one or more passenger molecules is a protein. At least one of the one or more passenger molecules is an enzyme. The sol-gel is a silica-based sol-gel.
    Type: Application
    Filed: February 22, 2020
    Publication date: April 7, 2022
    Inventors: Leonard H. Rome, Ph.D., Shaily Mahendra, Meng Wang, Valerie Ann Kickhoefer, Esther Hui-Jen Lan, Bruce S. Dunn
  • Methods and compositions for making vault particles in yeast
    Patent number: 11261471
    Abstract: Disclosed herein are methods and compositions for making vault particles in yeast hosts and yeast vaults produced therefrom.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: March 1, 2022
    Assignees: The Regents of the University of California, Vault Pharma Inc.
    Inventors: Leonard H. Rome, Shaily Mahendra, Meng Wang, Valerie A. Kickhoefer, Oliver Karl Foellmer
  • Vault Complexes for Cytokine Delivery
    Publication number: 20200368319
    Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Inventors: Leonard H. Rome, Valerie Ann Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
  • HIV peptide vaults and methods of making and using thereof
    Patent number: 10821190
    Abstract: Disclosed herein are compositions comprising HIV peptide vaults, which are vault particles comprising complexes of MVP proteins and one or more HIV peptides bound or genetically linked to one or more MVP proteins or packaged within the internal cavities of the vault particles and methods of using thereof.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 3, 2020
    Assignee: The Regents of the University of California
    Inventors: Otto O. Yang, Leonard H. Rome, Jan Mrazek
  • Vault complexes for cytokine delivery
    Patent number: 10780147
    Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: September 22, 2020
    Assignees: The Regents of the University of California, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
  • Vaults engineered for hydrophobic drug delivery
    Patent number: 10676534
    Abstract: The invention relates to compositions of vault complexes for use as delivery agents for hydrophobic and/or aqueous insoluble therapeutic compounds. In one aspect, provided herein is a vault complex comprising a modified major vault protein (MVP), wherein the modified major vault protein comprises a fusion peptide, wherein said fusion peptide is fused to the N-terminus of the major vault protein, and wherein said peptide provides enhanced sequestering of a hydrophobic and/or aqueous insoluble therapeutic compound within the vault complex.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: June 9, 2020
    Assignee: The Regents of the University of California
    Inventors: Leonard H. Rome, Daniel Buehler, Heather D. Maynard
  • Methods and Compositions for Making Vault Particles in Yeast
    Publication number: 20190352689
    Abstract: Disclosed herein are methods and compositions for making vault particles in yeast hosts and yeast vaults produced therefrom.
    Type: Application
    Filed: May 16, 2019
    Publication date: November 21, 2019
    Inventors: Leonard H. Rome, Shaily Mahendra, Meng Wang, Valerie A. Kickhoefer, Oliver Karl Foellmer
  • HIV Peptide Vaults and Methods of Making and Using Thereof
    Publication number: 20190111146
    Abstract: Disclosed herein are compositions comprising HIV peptide vaults, which are vault particles comprising complexes of MVP proteins and one or more HIV peptides bound or genetically linked to one or more MVP proteins or packaged within the internal cavities of the vault particles and methods of using thereof.
    Type: Application
    Filed: May 1, 2017
    Publication date: April 18, 2019
    Inventors: Otto O. Yang, Leonard H. Rome, Jan Mrazek
  • Vault immunotherapy
    Patent number: 10166277
    Abstract: The invention relates to compositions of vault complexes for use as adjuvants for stimulating a cellular immune response to an antigen, for example a tumor antigen, and methods of using the vault complexes in the treatment of diseases, such as cancer.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: January 1, 2019
    Assignees: The Regents of the University of California, The United States of America represented by the Department of Veterans Affairs
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Sherven Sharma, Steven M. Dubinett, Isaac Yang, Linda M. Liau, Kathleen A. Kelly, Jian Yang, Upendra K. Kar, Cheryl Champion, Janina Jiang
  • Vault complexes
    Patent number: 9951107
    Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 24, 2018
    Assignees: The Regets of the University of California, The Scripps Research Institute
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen Nemerow, Cheng-Yu Lai, Christopher Wiethoff, Mu Han
  • Vault Complexes for Cytokine Delivery
    Publication number: 20170143797
    Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
    Type: Application
    Filed: February 3, 2017
    Publication date: May 25, 2017
    Applicants: The Regents of the University of California, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Leonard H. Rome, Ph.D., Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
  • Vault complexes for cytokine delivery
    Patent number: 9597372
    Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: March 21, 2017
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
  • Vault Immunotherapy
    Publication number: 20160367653
    Abstract: The invention relates to compositions of vault complexes for use as adjuvants for stimulating a cellular immune response to an antigen, for example a tumor antigen, and methods of using the vault complexes in the treatment of diseases, such as cancer.
    Type: Application
    Filed: September 5, 2016
    Publication date: December 22, 2016
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Sherven Sharma, Steven M. Dubinett, Isaac Yang, Linda M. Liau, Kathleen A. Kelly, Jian Yang, Upendra K. Kar, Cheryl Champion, Janina Jiang
  • Vault compositions for immunization
    Patent number: 9463232
    Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: October 11, 2016
    Assignee: The Regents of the University of California
    Inventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl Champion
  • Vaults Engineered for Hydrophobic Drug Delivery
    Publication number: 20160235862
    Abstract: The invention relates to compositions of vault complexes for use as delivery agents for hydrophobic and/or aqueous insoluble therapeutic compounds. In one aspect, provided herein is a vault complex comprising a modified major vault protein (MVP), wherein the modified major vault protein comprises a fusion peptide, wherein said fusion peptide is fused to the N-terminus of the major vault protein, and wherein said peptide provides enhanced sequestering of a hydrophobic and/or aqueous insoluble therapeutic compound within the vault complex.
    Type: Application
    Filed: October 17, 2014
    Publication date: August 18, 2016
    Inventors: Leonard H. Rome, Ph.D., Daniel Buehler, Heather D. Maynard
  • Vault Complexes for Facilitating Biomolecule Delivery
    Publication number: 20160068576
    Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
    Type: Application
    Filed: September 24, 2015
    Publication date: March 10, 2016
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen Nemerow, Cheng-Yu Lai, Christopher Wiethoff, Mu Han
  • Vault Compositions for Immunization
    Publication number: 20160008452
    Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.
    Type: Application
    Filed: September 24, 2015
    Publication date: January 14, 2016
    Inventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl Champion
  • Vault and Vault like Carrier Molecules
    Publication number: 20150368671
    Abstract: A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like particle. A method of preventing damage by one or more than one substance to an organism, to a specific tissue, to specific cells, or to an environmental medium, by sequestering the one or more than one substance within a vault-like particle. A method of delivering one or more than one substance or a sensor to an organism, to a specific tissue, to specific cells, or to an environmental medium. According to another embodiment of the present invention, there is provided a method of making vault-like particles, and making vault-like particles comprising one or more than one substance, or one or more than one sensor.
    Type: Application
    Filed: July 15, 2015
    Publication date: December 24, 2015
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Sujna Raval-Fernandes, Phoebe L. Stewart
  • Vault complexes for facilitating biomolecule delivery
    Patent number: 9181312
    Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: November 10, 2015
    Assignees: The Regents of the University of California, The Scripps Research Institute
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen R. Nemerow, Cheng-Yu Lai, Chris M. Weithoff, Mu Ri Han