Abstract: The invention provides methods for evaluating the therapeutic benefit of a combination therapy useful for treating a medical disorder, such as cancer.

Abstract: An improved venturi-style eductor apparatus for dispensing chemicals into a motive fluid stream where an eductor body FIG. 3 is manufactured by molding a chemically inert polymer material FIG. 2 around and inside a metallic insert FIG. 1. Opposing ends of the metallic insert may be threaded, flanged, or machined for push-in connection to facilitate mating with a motive fluid source and a dispensing device. By manufacturing an eductor assembly using a single-piece metal insert over-molded with an inert polymer provides improved chemical resistance for aggressive applications and allows improvements in venturi geometry not achievable using traditional machined components. This apparatus reduces manufacturing cost over current state-of-the-art eductor assemblies by using a single molding step to create flow-path geometry in the eductor body while retaining mechanical strength with the metallic insert FIG. 1.

Abstract: Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

Abstract: An improved venturi-style eductor apparatus for dispensing chemicals into a motive fluid stream where an eductor body FIG. 3 is manufactured by molding a chemically inert polymer material FIG. 2 around and inside a metallic insert FIG. 1. Opposing ends of the metallic insert may be threaded, flanged, or machined for push-in connection to facilitate mating with a motive fluid source and a dispensing device. By manufacturing an eductor assembly using a single-piece metal insert over-molded with an inert polymer provides improved chemical resistance for aggressive applications and allows improvements in venturi geometry not achievable using traditional machined components. This apparatus reduces manufacturing cost over current state-of-the-art eductor assemblies by using a single molding step to create flow-path geometry in the eductor body while retaining mechanical strength with the metallic insert FIG. 1.

Abstract: Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

Abstract: Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

Abstract: A toilet (13) has a nappy holder mounted thereon. The nappy holder (15) contains a nappy ((1),also known as a diaper) of the type comprising a main body portion (3) and a tongue portion (5) for collecting excreta from a baby. The nappy holder (15) is so arranged that the tongue portion is positioned away from the main body portion of the nappy, such that when the toilet is flushed, the flush washes over the tongue portion and washes excreta (such as faeces and urine) off the tongue portion and into the toilet bowl. The nappy holder may have a wire frame.

Abstract: Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

Abstract: Polyolefins, especially polypropylene, can be made flame retardant by the incorporation therein of a synergistic mixture of a selected hindered amine substituted by an alkoxy, cycloalkoxy or hydroxyalkoxy moiety and a selected organic or inorganic brominated and/or phosphorus containing flame retardant, such as ammonium polyphosphate or decabromodiphenyl oxide wherein the amount of organic or inorganic flame retardant required to achieve an acceptable level of flame retardancy is significantly reduced compared to that needed when the hindered amine is not present.

Abstract: Polyolefins, especially polypropylene, can be made flame retardant by the incorporation therein of a synergistic mixture of a selected hindered amine substituted by an alkoxy, cycloalkoxy or hydroxyalkoxy moiety and a selected organic or inorganic brominated and/or phosphorus containing flame retardant, such as ammonium polyphosphate or decabromodiphenyl oxide wherein the amount of organic or inorganic flame retardant required to achieve an acceptable level of flame retardancy is significantly reduced compared to that needed when the hindered amine is not present.

Abstract: Hindered amine compounds containing a group of the formula where G1 and G2 are independently alkyl of 1 to 4 carbon atoms or are together pentamethylene, Z1 and Z2 are each methyl, or Z1 and Z2 together form a linking moiety which may additionally be substituted by an ester, ether, amide, amino, carboxy or urethane group, and E is alkoxy, cycloalkoxy, aralkoxy, aryloxy, —O—CO—OZ3, —O—Si(Z4)3, —O—PO(OZ5)2 or —O—CH2—OZ6 where Z3, Z4, Z5 and Z6 are selected from the group consisting of hydrogen, an aliphatic, araliphatic and aromatic moiety, when added to a wide variety of polymeric substrates, particularly polyolefins and styrenic polymers, surprisingly bestow flame retardant properties to such compositions.

Abstract: Polyolefins, especially polypropylene, can be made flame retardant by the incorporation therein of a synergistic mixture of a selected hindered amine substituted by an alkoxy, cycloalkoxy or hydroxyalkoxy moiety and a selected organic or inorganic brominated and/or phosphorus containing flame retardant, such as ammonium polyphosphate or decabromodiphenyl oxide wherein the amount of organic or inorganic flame retardant required to achieve an acceptable level of flame retardancy is significantly reduced compared to that needed when the hindered amine is not present.

Abstract: Universal serial bus powered battery charger primarily intended for use in battery powered hand-held and other portable devices to charge the battery or batteries within the battery powered device when the same is connected to a host device, powered hub or a bus powered hub through a universal serial bus (USB) port. The battery charger includes one or more current limits to conform to the universal serial bus current supply limit set in the USB specification. Any of the universal serial bus voltage and current limits may be used to charge batteries in the battery powered device, such as single cell lithium-ion batteries. Various features are disclosed.

Abstract: Polyolefins, especially polypropylene, can be made flame retardant by the incorporation therein of a synergistic mixture of a selected hindered amine substituted by an alkoxy, cydoalkoxy or hydroxyalkoxy moiety and a selected organic or inorganic brominated and/or phosphorus containing flame retardant, such as ammonium polyphosphate or decabromodiphenyl oxide wherein the amount of organic or inorganic flame retardant required to achieve an acceptable level of flame retardancy is significantly reduced compared to that needed when the hindered amine is not present.

Abstract: A differential switching converter system is disclosed. The converter system includes a plurality of switching converters having at least first and second converters. The plurality of switching converters is coupled in a differential configuration across an output load. Each converter has at least first and second transistors configured to apply and receive energy to and from an energy storage element. The converter system also includes a controller, which is configured to control the operation of the first and second transistors of each converter. The controller synchronizes turn-on and turn-off of the first transistor in the first converter with that of the first transistor in the second converter. The controller also controls turn-on and turn-off of the second transistors in the first and second converters to provide first and second duty cycles, respectively.

Abstract: Universal serial bus powered battery charger primarily intended for use in battery powered hand-held and other portable devices to charge the battery or batteries within the battery powered device when the same is connected to a host device, powered hub or a bus powered hub through a universal serial bus (USB) port. The battery charger includes one or more current limits to conform to the universal serial bus current supply limit set in the USB specification. Any of the universal serial bus voltage and current limits may be used to charge batteries in the battery powered device, such as single cell lithium-ion batteries. Various features are disclosed.

Abstract: Hindered amine compounds containing a group of the formula 1

Abstract: The invention is directed to an unsintered spherical adsorbent particle composition having high mechanical strength and controlled pore size distribution, comprising finely divided silica hydrogel particles bonded together with a silica or metal oxide sol.

Abstract: The invention is directed to an unsintered spherical adsorbent particle composition having high mechanical strength and controlled pore size distribution, comprising finely divided silica hydrogel particles bonded together with a silica or metal oxide sol.

Abstract: A system for stabilizing an aircraft includes sensors positioned and disposed at predetermined locations on the aircraft and structured for sensing external forces acting on the aircraft at the sensor locations as a result of rapid changes in atmospheric conditions such as those associated with air turbulence and wind shear. A computer processor receives data from the sensors and activates one or more thrust generators positioned at predetermined locations of the aircraft to counteract the external forces and maintain the desired attitude and stability of the aircraft.