Abstract: The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with antibodies or T-cells in subjects having pre-clinical or clinical Insulin-Dependent Diabetes Mellitus (IDDM). These molecules are preferentially immunoreactive to T-cells in subjects having pre-clinical or clinical IDDM and are useful in the development of diagnostic, therapeutic and prophylactic agents for IDDM.

Abstract: The present invention relates generally to a method for treating or ameliorating the symptoms of or reducing or otherwise minimizing the risk of development of an autoimmune disease such as but not limited to autoimmune diabetes. More particularly, the present invention relates to the use of genetically modified hemopoietic stem cells and/or hemopoietic progenitor cells which express genetic material encoding one or more autoantigens which give rise to antigen-presenting cells that induce immune tolerance and/or protective immunity. The present invention provides, therefore, a method for the treatment and/or prophylaxis of autoimmune disease conditions such as type 1 diabetes.

Abstract: The present invention provides methods of prophylaxis and treatment of autoimmune disease conditions and agents useful for the same. Particularly, the present invention provides mucosa-mediated tolerance to protect against or ameliorate the symptoms associated with autoimmune pathology. More particularly, the present invention provides a method for preventing clinical insulin-dependent diabetes mellitus (IDDM) or preventing or reducing or ameliorating the effects of cynical IDDM by the aerosol administration of IDDM-associated autoantigens to mucosal surfaces.

Abstract: The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with antibodies or T-cells in subjects having pre-clinical or clinical Insulin-Dependent Diabetes Mellitus (IDDM). These molecules are preferentially immunoreactive to T-cells in subjects having pre-clinical or clinical IDDM and are useful in the development of diagnostic, therapeutic and prophylactic agents for IDDM.

Abstract: The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with antibodies or T-cells in subjects having pre-clinical or clinical Insulin-Dependent Diabetes Mellitus (IDDM). These molecules are preferentially immunoreactive to T-cells in subjects having pre-clinical or clinical IDDM and are useful in the development of diagnostic, therapeutic and prophylactic agents for IDDM.

Abstract: The present invention relates to the identification, cloning and sequencing of nucleic acid molecules encoding an isoform of the enzyme glutamic acid decarboxylase and further relates to the use of these molecules and/or peptides and polypeptides encoded thereby in diagnostic tests for Insulin Dependent Diabetes Mellitus and other diseases in which glutamic acid decarboxylase is an autoantigen and in the treatment of patients suffering from these diseases.

Abstract: The present invention relates to the identification, cloning and sequencing of nucleic acid molecules encoding an isoform of the enzyme glutamic acid decarboxylase and further relates to the use of these molecules and/or peptides and polypeptides encoded thereby in diagnostic tests for Insulin Dependent Diabetes Mellitus and other diseases in which glutamic acid decarboxylase is an autoantigen and in the treatment of patients suffering from these diseases.

Abstract: A hold-down device comprising first and second supports which are secured to an hydraulic shear or the like against vertical movement. First and second shafts are slidably received by the first and second supports and have a hold-down shoe secured to the lower ends thereof. An elongated member is secured and extends between the upper ends of the first and second supports and has a first tubular member slidably mounted thereon. An inclined member has one end secured to the first shaft and its other end secured to the upper end of an upstanding post which is secured to the hold-down shoe. A second tubular member is slidably mounted on the inclined member and is interconnected to the first tubular member by a web. A handle pivotally connects the post and the web so that movement of the handle in one direction causes the hold-down shoe to be lowered and so that pivotal movement of the handle in a direction opposite to the said one direction will cause the hold-down shoe to be raised.