Abstract: The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amount of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.

Abstract: A lifting mechanism for a sedimentation tank is provided for vertically raising and lowering a rake assembly in such sedimentation tank. The lifting mechanism comprises one or more elongate members pivotally connected to certain structural elements of the assemblage, such as the rotary drive motor, rake assembly, column or bridge. The pivotal connections of the elongate members are positioned about a horizontal axis and are oriented to receive the torque forces imposed on the assemblage as the rake assembly rotates in the tank simultaneously with vertical lifting. The torque forces are translated into the pivotal connections and are able to counteract those forces to facilitate vertically raising and lowering the rake assembly while it is being rotated in the sedimentation tank.

Abstract: A lifting mechanism for a sedimentation tank is provided for vertically raising and lowering a rake assembly in such sedimentation tank. The lifting mechanism comprises one or more elongate members pivotally connected to certain structural elements of the assemblage, such as the rotary drive motor, rake assembly, column or bridge. The pivotal connections of the elongate members are positioned about a horizontal axis and are oriented to receive the torque forces imposed on the assemblage as the rake assembly rotates in the tank simultaneously with vertical lifting. The torque forces are translated into the pivotal connections and are able to counteract those forces to facilitate vertically raising and lowering the rake assembly while it is being rotated in the sedimentation tank.

Abstract: A self-diluting feedwell for a thickener or settling tank includes a delivery pipe for providing an influent feed stream of slurry, a nozzle for directionally discharging the influent feed stream, and an eductor structure including a launder zone for receiving the nozzle discharge, a throat zone for creating a reduced pressure area for eduction of diluent into the launder zone, and a discharge zone for dispensing the diluted influent into a thickener or settling tank.

Abstract: A self-diluting feedwell for a thickener or settling tank includes a delivery pipe for providing an influent feed stream of slurry, a nozzle for directionally discharging the influent feed stream, and an eductor structure including a launder zone for receiving the nozzle discharge, a throat zone for creating a reduced pressure area for eduction of diluent into the launder zone, and a discharge zone for dispensing the diluted influent into a thickener or settling tank.

Abstract: A self-diluting feedwell for a thickener or settling tank includes a delivery pipe for providing an influent feed stream of slurry, a nozzle for directionally discharging the influent feed stream, and an eductor structure including a launder zone for receiving the nozzle discharge, a throat zone for creating a reduced pressure area for eduction of diluent into the launder zone, and a discharge zone for dispensing the diluted influent into a thickener or settling tank.

Abstract: A peripheral traction unit for a thickener is ground-mounted on a circular support base, normally of concrete, extending circularly at ground level below and exterior of the vertical walls of an above-ground thickener tank. A continuous rail and rack are mounted on a sole plate and integral key embedded and grouted in a support base pocket. A wheel and pinion assembly is provided on a traction frame so that the wheel rolls on the rail and the pinion meshes with the rack. The bottom of a box beam is pin-connected to the traction frame and the top of the box beam is fixedly connected to a rake-driving rotatable truss extending radially or diametrically across and above the tank wall. All erection, adjustment and maintenance of the traction unit is done at ground level rather than at the elevation of the upper edge of the tank wall where heretofore peripheral drive units have been positioned.

Abstract: A message handling system includes a computer controlled message processor for use in network configurations to store and forward low-speed messages between long distance and international communicators. Its use is based on dial-up connections between network nodes. Each message handler unit includes a microprocessor, program and buffer storage memories, line multiplexing circuitry, modems and input/output peripheral devices. The message handler unit may comprise a 32 port system, 30 of which are used as input ports and two of which are used as high-speed output ports. A journal of all message numbers is maintained on a printer for complete message accountability.

Abstract: A size mixture comprising a higher organic ketene dimer and polyoxyalkylene alkyl or alkyl-aryl ether or the corresponding mono- or di-ester is used to size paper products. In accordance with a preferred embodiment the liquid size mixture is added directly to the paper stock system without prior emulsification.

Abstract: A size mixture comprising a substituted cyclic dicarboxylic acid anhydride and polyoxyalkylene alkyl or alkyl-aryl ether or the corresponding mono- or di-ester is used to size paper products. In accordance with a preferred embodiment the liquid size mixture is added directly to the paper stock system without prior emulsification.

Abstract: A size mixture comprising a substituted cyclic dicarboxylic acid anhydride and polyoxyalkylene alkyl or alkylaryl ether or the corresponding mono- or di-ester is used to size paper products. In accordance with a preferred embodiment the liquid size mixture is added directly to the paper stock system without prior emulsification.