Patents by Inventor Leonard J. Deftos

Leonard J. Deftos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis and assessment of skeletal related disease using calcium 41
    Patent number: 8388930
    Abstract: A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope 41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope 41Ca by the patient, obtaining a sample of the radioactive calcium isotope 41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: March 5, 2013
    Assignees: Lawrence LIvermore National Security, LLC, The Regents of the University of California
    Inventors: Darren J. Hillegonds, John S. Vogel, Robert L. Fitzgerald, Leonard J. Deftos, David Herold, Douglas W. Burton
  • DIAGNOSIS AND ASSESSMENT OF SKELETAL RELATED DISEASE USING CALCIUM 41
    Publication number: 20120225486
    Abstract: A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope 41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope 41Ca by the patient, obtaining a sample of the radioactive calcium isotope 41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.
    Type: Application
    Filed: April 16, 2012
    Publication date: September 6, 2012
    Inventors: Darren J. Hillegonds, John S. Vogel, Robert L. Fitzgerald, Leonard J. Deftos, David Herold, Douglas W. Burton
  • Diagnosis and assessment of skeletal related disease using calcium 41
    Patent number: 8178076
    Abstract: A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope 41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope 41Ca by the patient, obtaining a sample of the radioactive calcium isotope 41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: May 15, 2012
    Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of California
    Inventors: Darren J. Hillegonds, John S. Vogel, Robert L. Fitzgerald, Leonard J. Deftos, David Herold, Douglas W. Burton
  • Liposome-calcitonin preparation
    Patent number: 4837380
    Abstract: A liposome-entrapped calcitonin composition and method of use is disclosed. The composition when parenterally administerd to a host mammal, produces an enhanced and prolonged hypocalcemic effect in said mammal and thus is useful in treating diseases related to abnormal skeletal metabolism. The liposomes are substantially free of cholesterol and may be single or multilamellar.
    Type: Grant
    Filed: March 17, 1987
    Date of Patent: June 6, 1989
    Assignee: Regents of University of California
    Inventors: Leonard J. Deftos, Karl Y. Hostetler
  • Method and composition for regulating serum calcium levels of mammals
    Patent number: 4692433
    Abstract: Method for regulating serum calcium levels in mammals by orally administering a composition which includes a polypeptide hormone such as parathyroid hormone (PTH) or calcitonin. The polypeptide hormone is protected from destruction in the digestive tract by encapsulation in liposomes. The liposome preferably includes a cationic amphiphilic agent so that the surface of the liposome has a net positive charge. Agents for enhancing the action of the liposome encapsulated hormones are also disclosed.
    Type: Grant
    Filed: August 1, 1985
    Date of Patent: September 8, 1987
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, Leonard J. Deftos
  • Region-specific determinants for vitamin K dependent bone protein
    Patent number: 4438208
    Abstract: Novel oligopeptide used as reagents or in the preparation of reagents in relation to gamma-carboxyglutamic acid-containing protein of bone. Particularly, labeled oligopeptides and antibodies prepared from immunogen conjugates are disclosed for use in immunoassays.
    Type: Grant
    Filed: May 27, 1982
    Date of Patent: March 20, 1984
    Assignee: The Regents of the University of California
    Inventors: Leonard J. Deftos, Bayard D. Catherwood