Abstract: The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

Abstract: An entitlement validation system for laser tag games having a laser tag vest arranged to be activatable for enabling game play has a ticketing module arranged to issue a ticket with a machine readable identification code upon payment made for a selected game, and to update a game entitlement database having identification codes matched with corresponding selected games, a ticket reader arranged to read the identification code of a ticket presented for game activation, a game controller arranged to receive the identification code transferred from the ticket reader and to activate the game equipment upon verifying of entitlement by matching the received identification code with the corresponding selected game in the database. The system may have a base station arranged as a communications link between the ticket reader and the game controller. The ticket reader may be integrated into the game equipment or installed in a validation activation station.

Abstract: An entitlement validation system for laser tag games having a laser tag vest arranged to be activatable for enabling game play has a ticketing module arranged to issue a ticket with a machine readable identification code upon payment made for a selected game, and to update a game entitlement database having identification codes matched with corresponding selected games, a ticket reader arranged to read the identification code of a ticket presented for game activation, a game controller arranged to receive the identification code transferred from the ticket reader and to activate the game equipment upon verifying of entitlement by matching the received identification code with the corresponding selected game in the database. The system may have a base station arranged as a communications link between the ticket reader and the game controller. The ticket reader may be integrated into the game equipment or installed in a validation activation station.

Abstract: A device for moving a tool along a passage, particularly for use in medical procedures, has two different aspects. In one aspect, a tool, e.g. a colonoscope, is surrounded by a sheath. The sheath has an inflatable region for engaging the passage wall, e.g. a colon. An annular extension region of the sheath is provided which becomes part of the inflated inflatable region thereby increasing its length as the fluid pressure acts against a head of a tool to draw the tool along the passage. The annular extension region has sheath parts which face one another by their relative orientation caused by crumpling of the extension region, or the sheath parts are provided by folded portions. The extension region moves together with the tool as the sheath parts sequentially move into the inflated inflatable region. In the other aspect, after inflation of the inflatable region of the sheath, inflation pressure acts against an inflatable head carried at the distal end region of the tool to draw the tool along the passage.

Abstract: A device for moving a tool along a passage, particularly for use in medical procedures, has two different aspects. In one aspect, a tool, e.g. a colonoscope, is surrounded by a sheath. The sheath has an inflatable region for engaging the passage wall, e.g. a colon. An annular extension region of the sheath is provided which becomes part of the inflated inflatable region thereby increasing its length as the fluid pressure acts against a head of a tool to draw the tool along the passage. The annular extension region has sheath parts which face one another by their relative orientation caused by crumpling of the extension region, or the sheath parts are provided by folded portions. The extension region moves together with the tool as the sheath parts sequentially move into the inflated inflatable region.

Abstract: A high density wirebond connector assembly (10), including an enclosure (12), a circuit board (14), a high density connector (16), a connector housing (18), and a plurality of nail contacts (20). The circuit board (14) is comprised of a plurality of laminate layers (26) and rows of wirebond pads (28) positioned on the laminate layers (26). A plurality of wirebonds (32) run between individual nail contacts (20) and individual wirebond pads (28). By increasing the density of the high density connector (16), and decreasing the distance between the wirebond pads (28) and the nail contacts (20), a smaller, lighter, cheaper, and vibrationally resistant high density connector assembly (10) is provided.

Abstract: A latching mechanism for an instrument delivery system having a base, a slide tray, movable relative to the base between an opened position and a closed position, wherein the latching mechanism comprises: an actuating unit, including a push button mounted on the slide tray, for moving a member from a first position to a second position in response to movement of the push button from an extended position to a depressed position; and a latching unit for latching the slide tray in at least one of the opened position and the closed position when the member is in the first position and for unlocking the slide tray when the member is in the second position.

Abstract: Apparatus for sorting pieces of non-ferrous scrap metal into a plurality of components, each component being a particular metal type, feeds the pieces into a vertically disposed sorting zone. The pieces fall down a steeply inclined guide member under the influence of gravity and they pass a pair of timing devices which are spaced apart along the guide member, each timing device being a light source on one side of the path of the pieces and a light detector on the other side. The timing devices provide signals representing not only timing but also size an velocity. The pieces then pass an x-ray analysis system including a source of high energy rays to induce x-ray fluorescence and a detector to detect this fluorescence. The detector provides signals indicating the metal type for each piece of scrap. The pieces then fall past a plurality of blast nozzles spaced apart along the guide member.

Abstract: A method of and apparatus for sorting pieces or particles of radioactive ore where the particles are moved one after another substantially horizontally then discharged into a gravity-accelerated trajectory which is substantially free-fall but can be controlled to follow a modified path by a low-friction slide plate. The falling particles pass a plurality of radiation detectors arranged in line along their path with increasing velocity due to gravity providing the required separation of the pieces so that each detector is subject to the radiations of essentially only one piece at a time. The size and number of detectors and the path length covered by the detectors is determined by the size of the pieces and the cut-off grade and accuracy required. All counts corresponding to a particular piece and derived successively from the plurality of detectors are accumulated since accuracy increases and percentage of probable error decreases with increased total count.

Abstract: A method of and apparatus for sorting pieces or particles of radioactive ore where the particles are moved through the apparatus in an asynchronous or non-constant manner. The particles are moved one at a time to a position in front of a radiation detector where they are temporarily stopped. The counts from the particle are accumulated with respect to time. In a control unit of the apparatus there is data representing a cut-off grade radiation rate and early upper and lower decision limits are established with regard to the cut-off rate. As soon as the accumulated count/time ratio from the detector exceeds the upper limmit or falls below the lower limit, the control unit is able to provide a decision to accept or reject the particle. If the particles are not closely sized then the size of each particle is determined before it is positioned in front of the radiation detector and the size determination is used to modify the cut-off grade and upper and lower early decision limits.