Abstract: In alternative embodiments, provided are mandibular advancement devices (MADs) fabricated having polymeric materials to impart advantageous properties to the MADs. In alternative embodiments, MADs as provided herein comprise an upper splint and a lower splint, wherein the upper splint comprises one or more upper fins; the lower splints comprise one or more lower fins; wherein the upper and lower splints are made of a polymeric material (PM) having a Young's Modulus of between about 0.1 to about 10 GPa, and methods for making and using them. In alternative embodiments, provided are methods for treating bruxism or a sleep-related breathing disorder, wherein optionally the sleep-related breathing disorder is obstructive sleep apnea (OSA) or snoring, and/or a TMJ disorder comprising use of a MAD as provided herein.

Abstract: Disclosed herein are mandibular advancement devices comprising an upper splint and a lower splint, where the upper splint comprises one or more upper fins, where each upper fin is located at a distance UD from back of the upper splint; the lower splints comprise one or more lower fins, where each lower fin is located at a distance LD from back of the lower splint; where the position of the upper and lower fins is unchangeable. Also disclosed are methods of reducing partial constriction of airway during sleep for a patient, the method comprising identifying a patient in need thereof; and administering to the patient the disclosed mandibular advancement device. Also disclosed are methods of manufacturing a mandibular advancement device, the method comprising obtaining measurements from a patient's dentition; digitally designing a mandibular advancement device; and milling the mandibular advancement device.

Abstract: Disclosed herein are mandibular advancement devices comprising an upper splint and a lower splint, where the upper splint comprises one or more upper fins, where each upper fin is located at a distance UD from back of the upper splint; the lower splints comprise one or more lower fins, where each lower fin is located at a distance LD from back of the lower splint; where the position of the upper and lower fins is unchangeable. Also disclosed are methods of reducing partial constriction of airway during sleep for a patient, the method comprising identifying a patient in need thereof; and administering to the patient the disclosed mandibular advancement device. Also disclosed are methods of manufacturing a mandibular advancement device, the method comprising obtaining measurements from a patient's dentition; digitally designing a mandibular advancement device; and milling the mandibular advancement device.

Abstract: Disclosed herein are methods of manufacturing an oral appliance, the method comprising the steps of: a) importing into a computer aided design (CAD) computer program a digitized data set obtained from a three-dimensional scan of a patient's dentition; b) preparing a three-dimensional electronic model of the patient's dentition; c) subtracting the three-dimensional electronic model of the patient's dentition from an image of a solid block to obtain an appliance data set; and d) manufacturing a dental appliance in accordance with the appliance data set. Also disclosed are devices made by the above method, and methods of treating a condition, for example a sleep breathing disorder, by using a device made by the above method.

Abstract: Disclosed herein are mandibular advancement devices comprising an upper splint and a lower splint, where the upper splint comprises one or more upper fins, where each upper fin is located at a distance UD from back of the upper splint; the lower splints comprise one or more lower fins, where each lower fin is located at a distance LD from back of the lower splint; where the position of the upper and lower fins is unchangeable. Also disclosed are methods of reducing partial constriction of airway during sleep for a patient, the method comprising identifying a patient in need thereof; and administering to the patient the disclosed mandibular advancement device. Also disclosed are methods of manufacturing a mandibular advancement device, the method comprising obtaining measurements from a patient's dentition; digitally designing a mandibular advancement device; and milling the mandibular advancement device.

Abstract: Disclosed herein are methods of manufacturing an oral appliance, the method comprising the steps of: a) importing into a computer aided design (CAD) computer program a digitized data set obtained from a three-dimensional scan of a patient's dentition; b) preparing a three-dimensional electronic model of the patient's dentition; c) subtracting the three-dimensional electronic model of the patient's dentition from an image of a solid block to obtain an appliance data set; and d) manufacturing a dental appliance in accordance with the appliance data set. Also disclosed are devices made by the above method, and methods of treating a condition, for example a sleep breathing disorder, by using a device made by the above method.

Abstract: Mandibular advancement devices (MAD) are disclosed comprising an upper splint, a lower splint, and at least one sensor, wherein the sensor measures a biological or biophysical aspect of a patient. Methods of using the devices are also disclosed.

Abstract: Disclosed herein are mandibular advancement devices comprising an upper splint and a lower splint, where the upper splint comprises one or more upper fins, where each upper fin is located at a distance UD from back of the upper splint; the lower splints comprise one or more lower fins, where each lower fin is located at a distance LD from back of the lower splint; where the position of the upper and lower fins is unchangeable. Also disclosed are methods of reducing partial constriction of airway during sleep for a patient, the method comprising identifying a patient in need thereof; and administering to the patient the disclosed mandibular advancement device. Also disclosed are methods of manufacturing a mandibular advancement device, the method comprising obtaining measurements from a patient's dentition; digitally designing a mandibular advancement device; and milling the mandibular advancement device.

Abstract: Disclosed herein are mandibular advancement devices comprising an upper splint and a lower splint, where the upper splint comprises one or more upper fins, where each upper fin is located at a distance UD from back of the upper splint; the lower splints comprise one or more lower fins, where each lower fin is located at a distance LD from back of the lower splint; where the position of the upper and lower fins is unchangeable. Also disclosed are methods of reducing partial constriction of airway during sleep for a patient, the method comprising identifying a patient in need thereof; and administering to the patient the disclosed mandibular advancement device. Also disclosed are methods of manufacturing a mandibular advancement device, the method comprising obtaining measurements from a patient's dentition; digitally designing a mandibular advancement device; and milling the mandibular advancement device.

Abstract: Disclosed herein are methods of manufacturing an oral appliance, the method comprising the steps of: a) importing into a computer aided design (CAD) computer program a digitized data set obtained from a three-dimensional scan of a patient's dentition; b) preparing a three-dimensional electronic model of the patient's dentition; c) subtracting the three-dimensional electronic model of the patient's dentition from an image of a solid block to obtain an appliance data set; and d) manufacturing a dental appliance in accordance with the appliance data set. Also disclosed are devices made by the above method, and methods of treating a condition, for example a sleep breathing disorder, by using a device made by the above method.

Abstract: Disclosed herein are methods of manufacturing a dental device, the method comprising: obtaining a set of clinical options for the dental device from a health care provider; creating a first data set from the set of clinical options; communicating the data set to a computer aided design (CAD) software; preparing a digital design for the dental device using the CAD software; communicating the digital design to an automated milling apparatus; and automatedly milling a block of polymer to obtain the dental device. Also disclosed are dental devices manufactured by the above method. Further disclosed are methods of treating or ameliorating apnea jaw-related disorder in a patient, the method comprising obtaining a dental device manufactured by the above method and positioning the dental device over the dentition prior to sleep, whereby the mandible is advanced forward relative to the maxilla, thereby ameliorating the symptoms of sleep apnea or the jaw-related disorder.

Abstract: Disclosed herein are mandibular advancement devices comprising an upper splint and a lower splint, where the upper splint comprises one or more upper fins, where each upper fin is located at a distance UD from back of the upper splint; the lower splints comprise one or more lower fins, where each lower fin is located at a distance LD from back of the lower splint; where the position of the upper and lower fins is unchangeable. Also disclosed are methods of reducing partial constriction of airway during sleep for a patient, the method comprising identifying a patient in need thereof; and administering to the patient the disclosed mandibular advancement device. Also disclosed are methods of manufacturing a mandibular advancement device, the method comprising obtaining measurements from a patient's dentition; digitally designing a mandibular advancement device; and milling the mandibular advancement device.

Abstract: Disclosed herein are splints for a mandibular advancement device, each splint comprising one or more guided fins, wherein each guided fin is located at a distance D from back of the splint; a back post; at least one threaded rod connecting the back post to the guided fin, wherein the distance between the guided fin and the back post is changed when the threaded rod is turned either clockwise or counterclockwise; and a guiding mechanism.

Abstract: Disclosed are asymmetrical splints for a mandibular advancement device (MAD) for use with a patient having an asymmetrical dentition, wherein the asymmetry of the splint complements the asymmetry of the dentition such that when the MAD is used to advance the mandible, the mandible is advanced symmetrically. Also disclosed are methods of manufacture and use of the splints.

Abstract: Disclosed herein are splints for a mandibular advancement device, each splint comprising one or more guided fins, wherein each guided fin is located at a distance D from back of the splint; a back post; at least one threaded rod connecting the back post to the guided fin, wherein the distance between the guided fin and the back post is changed when the threaded rod is turned either clockwise or counterclockwise; and a guiding mechanism.

Abstract: Disclosed herein are splints for a mandibular advancement device, each splint comprising one or more guided fins, wherein each guided fin is located at a distance D from back of the splint; a back post; at least one threaded rod connecting the back post to the guided fin, wherein the distance between the guided fin and the back post is changed when the threaded rod is turned either clockwise or counterclockwise; and a guiding mechanism.

Abstract: Disclosed herein are methods of manufacturing an oral appliance, the method comprising the steps of: a) importing into a computer aided design (CAD) computer program a digitized data set obtained from a three-dimensional scan of a patient's dentition; b) preparing a three-dimensional electronic model of the patient's dentition; c) subtracting the three-dimensional electronic model of the patient's dentition from an image of a solid block to obtain an appliance data set; and d) manufacturing a dental appliance in accordance with the appliance data set. Also disclosed are devices made by the above method, and methods of treating a condition, for example a sleep breathing disorder, by using a device made by the above method.

Abstract: A method for producing a one-piece orthodontic jig and brackets employs a computer-aided design (CAD) system to create a model of a patient's dental anatomy. A set of orthodontic brackets and their desired positions are also designed in the CAD model. An orthodontic jig for temporarily positioning the brackets during the bonding process is then designed that includes features for registering the jig to selected teeth, together with connecting members that detachably connect the brackets to the jig and hold the brackets in their desired position on the patient's teeth during the bonding process. The orthodontic jig and brackets is fabricated as a single piece by computer-controlled manufacturing (e.g., 3D printing) based on the CAD model.

Abstract: Disclosed herein are sleeves for use with a fin of a mandibular advancement device (MAD), the sleeve comprising: a shell, having a wall defining a hollow interior, wherein the wall encloses the hollow interior on all sides except one, leaving an opening at one end of the body; the wall has a thickness in the range of from about 1 nm to about 5 mm; the hollow interior comprises approximately the same size and dimensions as the fin of the MAD. Also disclosed are MADs that use the sleeves. Also disclosed are methods of treating a patient using MADs that use the sleeves.