Patents by Inventor Leonard Mackles

Leonard Mackles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150238615
    Abstract: There are provided pharmaceutical compositions comprising a sympathomimetic amine, one or more amino polymers and one or more enteric polymeric compounds insoluble in water at pH below 5.5 the combination of which acts both to interfere with the isolation of the sympathomimetic amine from the composition and to interfere with the conversion of the sympathomimetic amine to another pharmacologically active compound, all of said components being well mixed with each other.
    Type: Application
    Filed: November 20, 2012
    Publication date: August 27, 2015
    Inventors: Leonard Mackles, William Bess
  • Publication number: 20140329779
    Abstract: The invention discloses a solid transparent vehicle utilizing DBS in which a topical pharmaceutical active or cosmetic active is solubilized without the use of a monohydric and/or polyhydric alcohol thus providing a non-tacky, clear solid, which prevents segregation and insures uniformity in dosing.
    Type: Application
    Filed: January 22, 2013
    Publication date: November 6, 2014
    Applicant: PRODUCT AND TECHNOLOGY PARTNERS LLC
    Inventors: Leonard Mackles, William Bess
  • Publication number: 20120240937
    Abstract: This invention relates to novel articles, particularly latex barrier articles, being coated with an antimicrobial coating useful to reduce the risk of cross-contamination and/or infection by harmful pathogenic microorganisms.
    Type: Application
    Filed: December 9, 2010
    Publication date: September 27, 2012
    Applicant: GlaxoSmithKline LLC
    Inventors: William Bess, Leonard Mackles
  • Publication number: 20120094882
    Abstract: There is provided a tasteless denture cleaning composition comprising inter alia, a source of hypochlorite, a source of sulfite and precipitated silica gel.
    Type: Application
    Filed: October 15, 2010
    Publication date: April 19, 2012
    Inventors: Leonard Mackles, William Bess
  • Patent number: 7741366
    Abstract: There is provided a new technology that will allow the formulation of pharmaceutically active organic acid products at relatively high pH during storage. This affords the advantages of avoiding formulation with the acid form of the product, yet when the product is used, the pH will be reduced via a chemical reaction, thus forming the organic acid which is the active form of the product. A by-product of the reaction is a significant increase in temperature, thus adding to the efficacy of the organic acid.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: June 22, 2010
    Inventors: Leonard Mackles, William Bess
  • Publication number: 20090176738
    Abstract: There is provided a means of applying a heated medicament to the skin and concurrently hydrating the skin thus raising the efficacy of administration.
    Type: Application
    Filed: December 9, 2008
    Publication date: July 9, 2009
    Inventors: Leonard Mackles, William Bess
  • Publication number: 20090165220
    Abstract: There is provided a shelf stable two part aqueous based depilatory system comprising an acidic oxidative phase and a basic reductive phase containing, inter alia at least one depilatory compound, wherein the mixing of the two phases provides a substantially neutral warm depilatory mixture.
    Type: Application
    Filed: December 4, 2008
    Publication date: July 2, 2009
    Inventors: Leonard Mackles, William Bass
  • Publication number: 20090053321
    Abstract: There are provided vaginal rinse compositions, consisting essentially of :a) 1-20 wt % of a mucosally acceptable peroxide, b) 0.5-15 wt % of a mucosally acceptable sulfate, bisulfate, pyrosulfate salt of an inorganic cation or mixtures thereof, and c) water to 100 wt %. There are further provided methods of preparing and using said compositions as well as kits for maintaining the components to prepare said compositions.
    Type: Application
    Filed: October 16, 2008
    Publication date: February 26, 2009
    Inventors: Leonard Mackles, Bess William
  • Publication number: 20080089914
    Abstract: There is provided a new technology that will allow the formulation of pharmaceutically active organic acid products at relatively high pH during storage. This affords the advantages of avoiding formulation with the acid form of the product, yet when the product is used, the pH will be reduced via a chemical reaction, thus forming the organic acid which is the active form of the product. A by-product of the reaction is a significant increase in temperature, thus adding to the efficacy of the organic acid.
    Type: Application
    Filed: January 24, 2007
    Publication date: April 17, 2008
    Inventors: Leonard Mackles, Williams Bess
  • Patent number: 7332528
    Abstract: There are provided safe, tasteless, odorless, non-aqueous liquid spray compositions formulated for administration to the nasal cavity consisting essentially of pharmacologically acceptable non aqueous liquid carrier in which said bioactive material is directly insoluble, a pharmacologically acceptable water insoluble ester of a water soluble acid soluble in said carrier, a pharmacologically acceptable water soluble glycol soluble in said ester and a pharmacologically acceptable water soluble bio-active material soluble in said glycol but not directly soluble in the carrier. There are also provided methods of producing and administering such compositions.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: February 19, 2008
    Inventor: Leonard Mackles
  • Publication number: 20070190089
    Abstract: This invention provides antiperspirants to combat axillary body odor by preventing or reducing perspiration, wherein the antiperspirant comprises a water-soluble ester to reduce the problems associated with stickiness and residue. The present invention provides a new class of detackifying agents that are easily formulated into clear, aqueous based antiperspirant formulations. These agents are readily water soluble, provide clear cosmetically elegant products and eliminate the stickiness and tackiness normally associated with aqueous based products.
    Type: Application
    Filed: February 2, 2007
    Publication date: August 16, 2007
    Inventors: Leonard Mackles, William Bess
  • Publication number: 20070166245
    Abstract: Propellant free foamable aqueous dentifrice system which is capable of being delivered as a foam to a toothbrush and which is stable on the brush and when placed in the mouth and used for tooth cleaning, continues to generate more foam. The system is liquid and as such can not be used without being foamed because it is so thin that it falls beneath the bristles of the toothbrush.
    Type: Application
    Filed: October 23, 2006
    Publication date: July 19, 2007
    Inventors: Leonard Mackles, William Bess
  • Patent number: 7192573
    Abstract: There are provided oral mouth rinse compositions, consisting essentially of: a) 1–20 wt % of an orally acceptable peroxide, b) 0.5–15 wt % of an orally acceptable sulfate, bisulfate, pyrosulfate salt of an inorganic cation or mixtures thereof, and c) water to 100 wt %. There are further provided methods of preparing and using said compositions as well as kits for maintaining the components to prepare said compositions.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: March 20, 2007
    Inventors: Leonard Mackles, William S Bess
  • Publication number: 20060257499
    Abstract: There are provided vaginal rinse compositions, consisting essentially of: a) 1-20 wt % of a mucosally acceptable peroxide, b) 0.5-15 wt % of a mucosally acceptable sulfate, bisulfate, pyrosulfate salt of an inorganic cation or mixtures thereof, and c) water to 100 wt %. There are further provided methods of preparing and using said compositions as well as kits for maintaining the components to prepare said compositions.
    Type: Application
    Filed: June 8, 2006
    Publication date: November 16, 2006
    Inventors: Leonard Mackles, William Bess
  • Publication number: 20060134021
    Abstract: There are provided oral mouth rinse compositions, consisting essentially of: a) 1-20 wt % of an orally acceptable peroxide, b) 0.5-15 wt % of an orally acceptable sulfate, bisulfate, pyrosulfate salt of an inorganic cation or mixtures thereof, and c) water to 100 wt %. There are further provided methods of preparing and using said compositions as well as kits for maintaining the components to prepare said compositions.
    Type: Application
    Filed: December 22, 2004
    Publication date: June 22, 2006
    Inventors: Leonard Mackles, William Bess
  • Publication number: 20060134022
    Abstract: Effective stimulation of oral salivary activity in the oral cavity is achieved by the introduction thereinto of a warm aqueous solution, containing 0.5-15 wt % of an inorganic cation salt of a sulfate, bisulfate pyrosulfate or mixture thereof, having a temperature of at least 103° F. (39.4° C.).
    Type: Application
    Filed: October 21, 2005
    Publication date: June 22, 2006
    Inventors: Leonard Mackles, William Bess
  • Patent number: 7022740
    Abstract: There are provided lubricious ophthalmic solutions having a pH of between about 7.0 and about 8.0, consisting essentially of an aqueous solution of from about 0.5–4% by weight of a monographed polyol, borate calculated as the borate equivalent of 20–100% by weight of boric acid relative to said polyol, from about 0.1 to about 1.00% by weight of monographed polysorbate, a monographed preservative and a buffer. Suitably the polyol is polyvinyl alcohol In addition to polyvinyl alcohol (hereinafter PVA) the solution may include other monographed polymers as well as monographed pharmacologically active substances.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: April 4, 2006
    Inventor: Leonard Mackles
  • Publication number: 20060024237
    Abstract: There are provided safe, tasteless, odorless, non-aqueous liquid spray compositions formulated for administration to the nasal cavity consisting essentially of pharmacologically acceptable non aqueous liquid carrier in which said bioactive material is directly insoluble, a pharmacologically acceptable water insoluble ester of a water soluble acid soluble in said carrier, a pharmacologically acceptable water soluble glycol soluble in said ester and a pharmacologically acceptable water soluble bio-active material soluble in said glycol but not directly soluble in the carrier. There are also provided methods of producing and administering such compositions.
    Type: Application
    Filed: September 10, 2003
    Publication date: February 2, 2006
    Inventor: Leonard Mackles
  • Publication number: 20050245618
    Abstract: There are provided lubricious ophthalmic solutions having a pH of between about 7.0 and about 8.0, consisting essentially of an aqueous solution of from about 0.5-4% by weight of a monographed polyol, borate calculated as the borate equivalent of 20-100% by weight of boric acid relative to said polyol, from about 0.1 to about 1.00% by weight of monographed polysorbate, a monographed preservative and a buffer. Suitably the polyol is polyvinyl alcohol In addition to polyvinyl alcohol (hereinafter PVA) the solution may include other monographed polymers as well as monographed pharmacologically active substances.
    Type: Application
    Filed: April 29, 2004
    Publication date: November 3, 2005
    Inventor: Leonard MacKles
  • Publication number: 20050245484
    Abstract: A novel class of lubricious ophthalmic solutions is formulated to permit the use of a recognized class of demulcents; namely, anionic polymeric demulcents in the presence of a cationic quaternary germicide wherein no precipitation of said germicide occurs.
    Type: Application
    Filed: September 22, 2004
    Publication date: November 3, 2005
    Inventor: Leonard Mackles