Patents by Inventor Leonard R. Hecker

Leonard R. Hecker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Patent number: 7855203
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: December 21, 2010
    Assignee: Ortho-McNeil-Janssen Pharmaceuticals, Inc.
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Kimberly White, Hong Ye, Leonard R. Hecker, David F. McComsey
  • SUBSTITUTED PYRROLINES AS KINASE INHIBITORS
    Publication number: 20100240650
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 25, 2010
    Publication date: September 23, 2010
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7759380
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: July 20, 2010
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7608634
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: October 27, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7232906
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 19, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Indoloazepines as vasopressin receptor antagonists
    Patent number: 6765004
    Abstract: The invention is directed to tricyclic indoloazepine compounds useful as vasopressin receptor antagonists, pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions involving increased vascular resistance and cardiac insufficiency which include hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis or water retention in a subject in need thereof.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: July 20, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: William J. Hoekstra, Michael N. Greco, Leonard R. Hecker, Bruce E. Maryanoff, Jay M. Matthews
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20040054180
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 4, 2003
    Publication date: March 18, 2004
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • 2-amino-4,5-dihydro-1H-imidazole-1-carboxanilides
    Patent number: 4618682
    Abstract: Novel 2-amino-4,5-dihydro-1H-imidazole-1-carboxanilides, which are made by reacting 2-amino-4,5-dihydroimidazole with an aryl isocyanate, are made stable to rearrangement when converted to acid addition salt form, and are useful either as antihypertensive agents and/or antisecretary agents, as well as being intermediates to prepare known pharmacologically active N-aryl-N'-(4,5-dihydro-1H-imidazol-2-yl)ureas.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: October 21, 1986
    Assignee: McNeilab, Inc.
    Inventor: Leonard R. Hecker
  • 2-Amino-4,5-dihydro-1H-imizole-1-carboxanilides
    Patent number: 4513140
    Abstract: Novel 2-amino-4,5-dihydro-1H-imidazole-1-carboxanilides, which are made by reacting 2-amino-4,5-dihydroimidazole with an aryl isocyanate, are made stable to rearrangement when converted to acid addition salt form, and are useful either as antihypertensive agents and/or antisecretary agents, as well as being intermediates to prepare known pharmacologically active N-aryl-N'-(4,5-dihydro-1H-imidazol-2-yl)ureas.
    Type: Grant
    Filed: July 18, 1983
    Date of Patent: April 23, 1985
    Assignee: McNeilab, Inc.
    Inventor: Leonard R. Hecker