Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.

Abstract: A thermodynamic system containing a working fluid is disclosed. The thermodynamic system comprises at least a working fluid collection vessel (11) adapted to contain a liquid phase and a gaseous phase of the working fluid in thermodynamic equilibrium. A chilling arrangement (51) is functionally coupled to the fluid collection vessel (11) and adapted to remove heat from the working fluid collected in the working fluid collection vessel (11) and thereby reduce pressure in said thermodynamic system. Also disclosed are methods for depressurizing a thermodynamic system containing a working fluid in liquid/gas equilibrium.

Abstract: A method for operating start-up of a compressor train is disclosed. The train includes a driver machine and at least a centrifugal compressor drivingly coupled to the driver machine. The centrifugal compressor in turn includes a plurality of compressor stages and at least a first set of variable inlet guide vanes at an inlet of one of the compressor stages. The method includes at least partly closing the first set of variable inlet guide vanes; when the first set of variable inlet guide vanes is at least partly closed, starting rotation of the centrifugal compressor and accelerating the centrifugal compressor up to a minimum operating speed; opening the at least one set of variable inlet guide vanes to increase the gas flow through the centrifugal compressor once the minimum operating speed has been achieved.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.

Abstract: The present invention relates to polypeptides which are covalently bound to aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD38. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD38.

Abstract: The present invention relates to polypeptides which are covalently bound to aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of carbonic anhydrase IX (CAIX).The invention also includes dmg conjugates comprising said peptides,conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CAIX.

Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of carbonic anhydrase IX (CAIX). The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CAIX.

Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD38.The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and dmg conjugates in preventing, suppressing or treating a disease or disorder mediated by CD38.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.

Abstract: The present invention relates to drug conjugates comprising bicyclic peptides specific for MT1-MMP conjugated to one or more effector and/or functional groups which have utility in targeted cancer therapy.

Abstract: A thermodynamic system containing a working fluid is disclosed. The thermodynamic system comprises at least a working fluid collection vessel (11) adapted to contain a liquid phase and a gaseous phase of the working fluid in thermodynamic equilibrium. A chilling arrangement (51) is functionally coupled to the fluid collection vessel (11) and adapted to remove heat from the working fluid collected in the working fluid collection vessel (11) and thereby reduce pressure in said thermodynamic system. Also disclosed are methods for depressurizing a thermodynamic system containing a working fluid in liquid/gas equilibrium.

Abstract: The method is used for uniforming temperature in a shaft supported by a fluid bearing during rotation of the shaft; a journal portion of the shaft is located inside the fluid bearing; at least one passage is provided inside the shaft at least along the journal portion so to cross it; at least one flow of heat-exchange fluid is established in the at least one passage; the method allows to overcome the problems due to the “Morton effect”. A bearing system implementing the method is advantageously used in a turbomachine.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.

Abstract: A dry gas seal for sealing the shaft of a turbomachinery, provided with means for the continuous health monitoring of the dry gas seal comprising one or more sensors adapted to measure strains and/or loads induced to the primary ring of the dry gas seal and/or strains induced to one or more of the elastic elements coupled to the primary ring and/or adapted to measure displacements of the primary ring or of an element coupled to the primary ring, for an early detection of failure of the seal, thus enabling main failures early detection capability and proactive maintenance actions.

Abstract: The shaft seal arrangement for a rotating turbomachine shaft having a rotation axis, comprises a rotor part and a stationary part. A dry gas seal is further provided, in combination with a cooling fluid volume arranged for receiving a cooling fluid and in heat exchange relationship with the dry gas seal. A venting arrangement collectively vents exhaust cooling fluid and dry sealing gas from the shaft seal arrangement.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.

Abstract: According to one aspect of the present disclosure, a natural gas liquefaction system (100) is provided. The system comprises an integrally-geared turbo-compressor (150) with a plurality of compressor stages; a prime mover (160) for driving the compressor; a pre-cooling loop (110), through which a first refrigerant is adapted to circulate, wherein one or more first compressor stages (151) of the plurality of compressor stages are adapted to pressurize the first refrigerant; a cooling loop (130), through which a second refrigerant is adapted to circulate, wherein one or more second compressor stages (155) of the plurality of compressor stages are adapted to pressurize the second refrigerant; a first heat exchanger device (170) for transferring heat from a natural gas and/or from the second refrigerant to the first refrigerant; and a second heat exchanger device (180) for transferring heat from the natural gas to the second refrigerant.

Abstract: The present invention relates to drug conjugates comprising bicyclic peptides specific for MT1-MMP conjugated to one or more effector and/or functional groups which have utility in targeted cancer therapy.