Patents by Inventor Leonardo De Vincentiis

Leonardo De Vincentiis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Furan derivatives having anti-ulcer activity
    Patent number: 4634701
    Abstract: Compounds of formula (I): ##STR1## wherein: A represents a CH-NO.sub.2 group or a N-CN group;B represents CH.sub.2, O, S or a direct bond;R represents a bicyclic or polycyclic residue, variously substituted and functionalized;R.sup.1 and R.sup.2, which may be the same or different, are hydrogen or C.sub.1 -C.sub.4 alkyl groups; andn and m, which may be the same or different, are 0, 1, 2, 3 or 4;are valuable pharmacological agents.
    Type: Grant
    Filed: May 28, 1985
    Date of Patent: January 6, 1987
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Vasodilator compound and pharmaceutical compositions therefrom
    Patent number: 4503076
    Abstract: The compound N-(2,6-dichlorophenyl)acetamidine ##STR1## and its addition salts with pharmaceutically compatible inorganic and organic acids, exhibit a fast, strong vasodilator and antihypertensive action, which is of prolonged duration.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: March 5, 1985
    Assignee: Ausonia Farmaceutic s.r.l.
    Inventor: Leonardo De Vincentiis
  • 2-Hydroxy-3-(o-methoxy-phenoxy)propyl 2-(p-isobutyl-phenyl)-propionate and pharmaceutical compositions containing the same
    Patent number: 4501914
    Abstract: 2-Hydroxy-3-(o-methoxy-phenoxy)propyl 2-(p-isobutyl-phenyl)-propionate of formula (I) ##STR1## has marked analgesic, anti-inflammatory and muco-regulatory properties.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: February 26, 1985
    Assignee: Ausonia Farmaceutici S.r.l.
    Inventor: Leonardo De Vincentiis
  • Anti-inflammatory, disinfectant and anti-bacterial compound
    Patent number: 4496589
    Abstract: (+)-6-methoxy-.alpha.-methyl-2-naphthalene acetate of N,N"-bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecan-diimidoamide, possessing the formula (I) ##STR1## has high bioavailability by the cutaneous route which enables it to be used topically for the treatment of dermatoses, infected wounds, scalds, bedsores, inflammations of the oral cavity, vulvovaginitis, etc.
    Type: Grant
    Filed: November 4, 1982
    Date of Patent: January 29, 1985
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Phthalidyl apovincaminate with cerebral eubolic activity
    Patent number: 4486437
    Abstract: 13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo (3,2,1-de)pyrido (3,2,1-ij) (1,5) naphthiridin-12-phthalidile carboxylate, having the formula given below, and a procedure for its preparation, are described. ##STR1## The compound lends itself to the prevention and treatment of cerebrovascular affections and organic and functional syndromes caused by a deterioration of cerebral circulation.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: December 4, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Hexamethylenetetramine-N-acetyl-thiazolidine-4-carboxylate, a process for its preparation and a pharmaceutical composition containing it
    Patent number: 4469691
    Abstract: Hexamethylenetetramine-N-acetyl-thiazolidine-4-carboxylate having formula (I) ##STR1## is endowed with antibacterial and mucosecretolytic properties. These properties along with the very low toxicity of the compound (I) make it particularly suited for the chemotherapeutical treatment of the affections of the urinary and intestinal tracts, and for the treatment of bladder and intestinal catarrhs.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: September 4, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositio ns therefrom
    Patent number: 4440786
    Abstract: The compound (2',4'-difluoro-4-biphenyl)oxyacetic acid and its pharmaceutically acceptable salts with a metal or an organic base are described. They exhibit high antiinflammatory and analgesic activity and do not cause gastric lesions.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: April 3, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo de Vincentiis
  • Compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom
    Patent number: 4440787
    Abstract: The compound (2',4'-difluoro-4-biphenyl)oxypropionic acid and its pharmaceutically acceptable salts with a metal or an organic base are described. They exhibit high antiinflammatory and analgesic activity and do not cause gastric lesions.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: April 3, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo de Vincentiis
  • Compound with analgesic, antiinflammatory and antipyretic activity, and pharmaceutical compositions therefrom
    Patent number: 4435591
    Abstract: The compound 2-(4-isobutylphenyl)1-propanol 3,4,5-trimethoxybenzoate is described. The substance is prepared by reacting 3,4,5-trimethoxybenzoic acid chloride with 2 (4-isobutylphenyl)1-propanol; preferably in the presence of an acid acceptor. The compound exhibits valuable analgesic, antiinflammatory and antipyretic properties.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: March 6, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Compound with antiulcerogenic activity, process for the preparation thereof and pharmaceutical composition therefrom
    Patent number: 4431664
    Abstract: The present invention relates to a new compound with antiulcerogenic activity, and precisely N-(2-(((5-di-methylamino)-methyl-2-furanyl)-methyl)-thio)-ethyl)-N'-(3,4-m ethylendioxybenzyl)-2-nitro-1,1-ethenediamine, of formula (I): ##STR1##
    Type: Grant
    Filed: August 5, 1982
    Date of Patent: February 14, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Pharmaceutical compositions endowed with an antibacterial activity and their use in the treatment of infections due to gram-positive and gram-negative pathogens
    Patent number: 4386070
    Abstract: Pharmaceutical compositions consisting of an antibiotic (cephalosporins, tetracyclines, kanamycin) associated with a heterocyclicic .beta.-ketoacid (nalidixic acid, oxolinic acid, cinoxacine, piromidic acid, pipemidic acid) are endowed with a marked synergism against Gram-positive and Gram-negative pathogens as well with a particularly relevant efficacy against antibiotic-resistant strains.
    Type: Grant
    Filed: February 27, 1981
    Date of Patent: May 31, 1983
    Assignee: Ausonia Farmaceutici S.R.L.
    Inventor: Leonardo De Vincentiis
  • .alpha.-(3,4,5-Trimethoxyhenzoyl)thiopropionyl-glycine
    Patent number: 4328242
    Abstract: A novel compound .alpha.-(3,4,5-Trimethoxybenzoyl)propionylglycine is described. The substance is more stable than 2-mercaptopropionylglycine and is useful for the therapy of subacute and chronic pathological conditions of the bronchi, acute and chronic conditions of the liver, and for the treatment of aftermaths of intoxication.
    Type: Grant
    Filed: January 5, 1981
    Date of Patent: May 4, 1982
    Assignee: Ausoria Farmaceutici S.r.l.
    Inventor: Leonardo De Vincentiis
  • Derivatives of methyl-substituted or methoxy-substituted 2-hydroxybenzoic acids, and pharmaceutical formulations containing them
    Patent number: 4317917
    Abstract: The invention relates to methyl- or methoxy-substituted 2-cynnamoyloxy-benzoic acids or to cynnamylesters of methyl- or methoxy-substituted 2-hydroxybenzoic acids, endowed with an interesting antiinflammatory, analgesic and antibacterial activity; and to a process for preparing said compounds.
    Type: Grant
    Filed: March 21, 1980
    Date of Patent: March 2, 1982
    Assignee: Ausonia Farmaceutici S.r.l.
    Inventor: Leonardo De Vincentiis