Abstract: Described is a unit for forming short pasta comprising at least one pin rotatable in a first direction of rotation about a first axis of rotation and at least one roller rotatable in a second direction of rotation opposite the first direction of rotation about a second axis of rotation parallel to the first axis of rotation; the roller is movable along a first operating direction at right angles to the first and the second axes of rotation between a non-operating position and an operating position alongside the pin; the forming unit comprises a punch movable in another operating direction at right angles to the first operating direction, to the first axis of rotation and to the second axis of rotation between a retracted position and an extracted position for feeding a piece of sheet to the pin and to the roller.

Abstract: Described is a unit for forming short pasta comprising at least one pin rotatable in a first direction of rotation about a first axis of rotation and at least one roller rotatable in a second direction of rotation opposite the first direction of rotation about a second axis of rotation parallel to the first axis of rotation; the roller is movable along a first operating direction at right angles to the first and the second axes of rotation between a non-operating position and an operating position alongside the pin; the forming unit comprises a punch movable in another operating direction at right angles to the first operating direction, to the first axis of rotation and to the second axis of rotation between a retracted position and an extracted position for feeding a piece of sheet to the pin and to the roller.

Abstract: Novel compounds, pharmaceutical compositions, and methods are provided for modulating processes mediated by nuclear hormone receptors. A partial or complete agonist or antagonist modulates, directly or indirectly, an activity of one or more nuclear hormone receptors for glucocorticoids (GRs), androgens (ARs), mineralocorticoids (MRs), progestins (PRs), estrogens (ERs), thyroid hormones (TRs), vitamin D (VDRs), retinoids (RARs and RXRs), peroxisomes (XPARs and PPARs), icosanoids (IRs), or one or more orphan receptors, such as steroid and thyroid receptors. Exemplary compounds of the disclosure are bacterial products, for example bacterial toxins, and these compounds are useful in screens for other antagonists and agonists. Related methods and compositions are provided for diagnosis, treatment and prevention of bacterial disease and associated or unrelated inflammatory, autoimmune, toxic (including shock), and chronic and/or lethal sequelae associated with bacterial infection.