Patents by Inventor Leonardo Velazco-Cruz

Leonardo Velazco-Cruz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR IMPROVING SC-BETA CELLS OR ENHANCING THEIR UTILITY
    Publication number: 20230392124
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for the generation of cells of endodermal lineage and beta cells and uses thereof.
    Type: Application
    Filed: April 16, 2021
    Publication date: December 7, 2023
    Applicant: Washington University
    Inventors: Jeffrey Millman, Kristina Maxwell, Nathaniel Hogrebe, Leonardo Velazco-Cruz, Daniel Veronese Paniagua
  • Methods and Compositions for Generating Functionally Mature Beta Cells and Uses Thereof
    Publication number: 20230014430
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for the generation of functionally mature beta cells having enhanced SIX2+ activity and therapeutic benefit and uses thereof. An aspect of the present disclosure provides for a method of generating SIX2-enhanced SC-? cells. In some embodiments, the method comprises providing a population of SC-? cells (or EP cells); providing a SIX2 positive regulator; and/or incubating the population of SC-? cells and the SIX2 positive regulator.
    Type: Application
    Filed: November 20, 2020
    Publication date: January 19, 2023
    Applicant: Washington University
    Inventors: Jeffrey Millman, Daniel Veronese Paniagua, Kristina Wernes, Leonardo Velazco-Cruz
  • MEDIA FOR CRYOPRESERVED CELLS AND METHODS OF MAKING AND USING SAME
    Publication number: 20220403340
    Abstract: Among the various aspects of the present disclosure is the provision of a media for cryopreserved cells and methods of making and using same. An aspect of the present disclosure provides for a cell media formulation comprising (e.g., for day 0) one or more components selected from: MCDB 131; Glutamax; P/S; BSA; Glucose; ZnSO4; an enzyme for digesting DNA (e.g., DNASE1); and/or an apoptosis inhibitor (e.g., BI-6C9).
    Type: Application
    Filed: June 13, 2022
    Publication date: December 22, 2022
    Inventors: Jeffrey Millman, Leonardo Velazco-Cruz, Punn Augsornworawat
  • METHODS AND COMPOSITIONS FOR GENERATING CELLS OF ENDODERMAL LINEAGE AND BETA CELLS AND USES THEREOF
    Publication number: 20210207099
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for the generation of cells of endodermal lineage and beta cells and uses thereof.
    Type: Application
    Filed: May 16, 2019
    Publication date: July 8, 2021
    Inventors: Jeffrey R. Millman, Nathaniel Hogrebe, Jiwon Song, Leonardo Velazco-Cruz