Patents by Inventor Leone G. Rotini

Leone G. Rotini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5480650
    Abstract: Programmed release tablets, to be administered by oral route, containing from 500 to 1,200 mg of naproxen, made by mixtures of an immediate release granulate dry compacted containing from 5% to 28% of naproxen, of a controlled release granulate dry compacted containing from 72% to 95% of naproxen and of a disintegrating agent. A portion of naproxen is released in a short time, so that the drug can quickly develop its therapeutic action reaching the necessary hematic levels, while the remaining portion is released in a longer interval of time, so as to allow the therapeutic coverage until the subsequent administration. The therapeutic coverage is effective for a period of 24 hours; thus the tablets object of the present invention are suitable for a once a day administration.
    Type: Grant
    Filed: September 1, 1993
    Date of Patent: January 2, 1996
    Assignee: Alfa Wassermann S.p.A.
    Inventors: Egidio Marchi, Leone G. Rotini
  • Patent number: 5352679
    Abstract: The antibiotic known by the name rifaximin (INN) is active orally in the treatment of gastric dyspepsia caused by bacteria known as Helicobacter pylori. Rifaximin may be administered in any oral pharmaceutical form, particularly tablets, capsules, sugar coated tablets, granules and syrups containing from 200 to 2000 mg of active principle, at a daily dosage of between 400 and 2000 mg.
    Type: Grant
    Filed: June 28, 1993
    Date of Patent: October 4, 1994
    Assignee: Alfa Wassermann S.p.A.
    Inventors: Antonella Ferrieri, Leone G. Rotini
  • Patent number: 5252339
    Abstract: Pharmaceutical compositions for oral use, preferably selected from capsules, tablets or sugar coated tablets, coated by an enterosoluble gastroresistant film, containing a lyophilizate consisting of therapeutically effective amounts of a glycosaminoglycan, a thickening substance and surfactants, and process for obtaining them. The compositions make possible the absorption of the orally administered glycosaminoglycans in the duodenum and in the intestine and the consequent performance of their anticoagulant, fibrinolytic, antithrombotic, antiatherosclerotic and antihyperlipoproteinemic properties.
    Type: Grant
    Filed: January 15, 1992
    Date of Patent: October 12, 1993
    Assignee: Alfa Wasserman S.p.A.
    Inventors: Manlio Cristofori, Egidio Marchi, Leone G. Rotini
  • Patent number: 5043167
    Abstract: New galenic formulations with programmed release, to be administered by the oral route, containing as the active ingredient a drug selected from the non steroidal antiinflammatory, bronchodilator, vasodilator, cardiovascular and muscle relaxant drugs.
    Type: Grant
    Filed: January 5, 1989
    Date of Patent: August 27, 1991
    Assignee: Alfa Wassermann S.p.A.
    Inventors: Leone G. Rotini, Egidio Marchi
  • Patent number: 4888178
    Abstract: A galenic formulations are disclosed with programmed release, to be administered orally containing as the active ingredient a compound having antiphlogistic, analgesic and antipyretic activity like, for instance, an arylacetic or an arylpropionic acid, and pharmaceutically acceptable salts thereof. In these new formulations, a portion of the active ingredient is released in a short time, so that the drug can quickly develop its therapeutic action and reach the necessary hematic levels, while the remaining portion of the active constituent is released in a longer interval of time so as to allow therapeutic coverage until subsequent administration. The therapeutic coverage can even last twenty-four hours. Thus, the new galenic formulations object of the present invention are suitable for administration one a day.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: December 19, 1989
    Assignee: Alfa Wassermann S.p.A.
    Inventors: Leone G. Rotini, Egidio Marchi