Patents by Inventor Leonhard JAITZ

Leonhard JAITZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of oligonucleotides using modified oxidation protocol
    Publication number: 20230322843
    Abstract: The invention relates to a process for the production of a mixed P?O/P?S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the scheme applying a novel oxidation protocol and to new oxidation solutions.
    Type: Application
    Filed: January 5, 2023
    Publication date: October 12, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Alec FETTES, Achim GEISER, Leonhard JAITZ
  • PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDES USING MODIFIED OXIDATION PROTOCOL
    Publication number: 20230295207
    Abstract: The invention relates to a process for the production of a mixed P?O/P?S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the scheme with an oxidation solution obtained by mixing iodine, an organic solvent and water, characterized in that the oxidation solution has been aged for a time period that is sufficient to selectively oxidize the phosphite triester compound of formula I into the phosphodiester compound of formula II without oxidizing the phosphorothioate intenucleotide linkages.
    Type: Application
    Filed: June 9, 2020
    Publication date: September 21, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Alec FETTES, Achim GEISER, Leonhard JAITZ, Hongrim CHOI, Kyeong Eun JUNG, Sung Won KIM