Patents by Inventor Leonid A. Gaydukov

Leonid A. Gaydukov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXOSOMES FOR IMMUNO-ONCOLOGY AND ANTI-INFLAMMATORY THERAPY
    Publication number: 20240010705
    Abstract: Disclosed herein are extracellular vesicles comprising an immunomodulating component. Also provided are methods for producing the extracellular vesicles and methods for using the extracellular vesicles for treating cancer, GvHD, and autoimmune diseases.
    Type: Application
    Filed: October 26, 2022
    Publication date: January 11, 2024
    Applicant: LONZA SALES AG
    Inventors: Nuruddeen D. LEWIS, Yu ZHOU, Sriram SATHYANARAYANAN, John KULMAN, Douglas E. WILLIAMS, Leonid A. GAYDUKOV, Ke XU, Shelly MARTIN
  • ANTI-TRANSFERRIN EXTRACELLULAR VESICLES
    Publication number: 20230220068
    Abstract: The present disclosure relates extracellular vesicles, e.g., exosomes, comprising an antigen-binding moeity, e.g., a single-domain antigen-binding moeity, e.g., a vNAR, a VHH, or a fragment thereof, that specifically binds transferrin receptor, and methods of making and using the same.
    Type: Application
    Filed: June 7, 2021
    Publication date: July 13, 2023
    Applicant: Codiak BioSciences, Inc.
    Inventors: Ajay VERMA, Leonid GAYDUKOV, Ke XU, Kevin P. DOOLEY, Jonathan FINN
  • METHODS OF GLYCOENGINEERING PROTEOGLYCANS WITH DISTINCT GLYCAN STRUCTURES
    Publication number: 20210115413
    Abstract: Disclosed herein are methods of generating proteoglycans with distinct glycan structures in engineered, non-naturally occurring eukaryotic cells. These methods make accessible a dynamic range of protein glycosylation. Compositions of engineered, non-naturally occurring cells capable of generating these proteoglycans are also disclosed herein.
    Type: Application
    Filed: June 20, 2019
    Publication date: April 22, 2021
    Applicants: Massachusetts Institute of Technology, Pfizer Inc.
    Inventors: Michelle Chang, Leonid A. Gaydukov, Giyoung Jung, Nevin M. Summers, Timothy Kuan-Ta Lu, Ron Weiss, John Scarcelli, Richard Cornell, Jeffrey Marshall, Bruno Figueroa, Wen Allen Tseng
  • EXOSOMES FOR IMMUNO-ONCOLOGY AND ANTI-INFLAMMATORY THERAPY
    Publication number: 20200407419
    Abstract: Disclosed herein are extracellular vesicles comprising an immunomodulating component. Also provided are methods for producing the extracellular vesicles and methods for using the extracellular vesicles for treating cancer, GvHD, and autoimmune diseases.
    Type: Application
    Filed: July 6, 2020
    Publication date: December 31, 2020
    Applicant: Codiak BioSciences, Inc.
    Inventors: Nuruddeen D. LEWIS, Yu ZHOU, Sriram SATHYANARAYANAN, John KULMAN, Douglas E. WILLIAMS, Leonid A. GAYDUKOV, Ke XU, Shelly MARTIN
  • Exosomes for immuno-oncology and anti-inflammatory therapy
    Patent number: 10723782
    Abstract: Disclosed herein are extracellular vesicles comprising an immunomodulating component. Also provided are methods for producing the extracellular vesicles and methods for using the extracellular vesicles for treating cancer, GvHD, and autoimmune diseases.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: July 28, 2020
    Assignee: Codiak BioSciences, Inc.
    Inventors: Nuruddeen D. Lewis, Yu Zhou, Sriram Sathyanarayanan, John D. Kulman, Douglas E. Williams, Leonid A. Gaydukov, Ke Xu, Shelly Martin
  • EXOSOMES FOR IMMUNO-ONCOLOGY AND ANTI-INFLAMMATORY THERAPY
    Publication number: 20190202892
    Abstract: Disclosed herein are extracellular vesicles comprising an immunomodulating component. Also provided are methods for producing the extracellular vesicles and methods for using the extracellular vesicles for treating cancer, GvHD, and autoimmune diseases.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 4, 2019
    Inventors: Nuruddeen D. Lewis, Yu Zhou, Sriram Sathyanarayanan, John D. Kulman, Douglas E. Williams, Leonid A. Gaydukov, Ke Xu, Shelly Martin
  • PON polypeptides, polynucleotides encoding same and compositions and methods utilizing same
    Patent number: 9023631
    Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 5, 2015
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Dan S. Tawfik, Amir Aharoni, Leonid Gaydukov, Joel L. Sussman, Israel Silman
  • PON POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND COMPOSITIONS AND METHODS UTILIZING SAME
    Publication number: 20140079682
    Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.
    Type: Application
    Filed: October 21, 2013
    Publication date: March 20, 2014
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Dan S. TAWFIK, Amir Aharoni, Leonid Gaydukov, Joel L. Sussman, Israel Silman
  • PON POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND COMPOSITIONS AND METHODS UTILIZING SAME
    Publication number: 20110171197
    Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 14, 2011
    Applicant: Yeda Research And Development Co. Ltd.
    Inventors: Dan S. TAWFIK, Amir Aharoni, Leonid Gaydukov, Joel L. Sussman, Israel Silman
  • Pon polypeptides polynucleotides encoding same and compositions and methods utilizing same
    Patent number: 7786071
    Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: August 31, 2010
    Assignee: Yeda Research And Development Co. Ltd.
    Inventors: Dan S. Tawfik, Amir Aharoni, Leonid Gaydukov, Joel L. Sussman, Israel Silman
  • METHODS OF DETERMINING TOTAL PON1 LEVEL
    Publication number: 20100099118
    Abstract: A method of determining an amount of total PON1 in a sample of a subject is disclosed. The method comprises: (a) contacting the sample with a compound being capable of generating at least one spectrophotometrically detectable moiety upon contact with PON1, under conditions wherein the generating is not dependent on a PON1 status; and (b) spectrophotometrically measuring a level of the moiety, thereby determining an amount of total PON1 in the sample. Kits for measuring total PON1 levels comprising the compounds are also disclosed.
    Type: Application
    Filed: March 11, 2008
    Publication date: April 22, 2010
    Applicant: Yeda Research And Development Co., Ltd.
    Inventors: Leonid Gaydukov, Olga Khersonsky, Dan S. Tawfik
  • Method Of Diagnosing Pon1-Hdl Associated Lipid Disorders
    Publication number: 20100028924
    Abstract: Methods and kits for diagnosing a lipid-related disorder are disclosed. Methods and pharmaceutical compositions for treating lipid-related disorders are also disclosed.
    Type: Application
    Filed: March 18, 2007
    Publication date: February 4, 2010
    Applicant: Rappaport Family Institute Research in the Medical Sciences
    Inventors: Leonid Gaydukov, Olga Khersonsky, Dan S. Tawfik, Michael Aviram
  • Pon polypeptides polynucleotides encoding same and compositions and methods utilizing same
    Publication number: 20060205933
    Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.
    Type: Application
    Filed: March 4, 2004
    Publication date: September 14, 2006
    Inventors: Dan Tawfik, Amir Aharoni, Leonid Gaydukov, Joel Sussman, Isreal Silman