Patents by Inventor Leonid B. Margolis

Leonid B. Margolis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit CCR5-tropic HIV-1 infection and replication
    Patent number: 7968298
    Abstract: It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: June 28, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Leonid B. Margolis, Jean-Charles Grivel, Paolo Lusso
  • In vitro model for viral infection and immune response
    Publication number: 20030203351
    Abstract: An in vitro model system for viral infection and for immune response is comprised of a tissue block from adult tonsil or lymph node supported on a matrix which is flexible and porous and wherein the supported tissue block is cultured in a medium whose surface is congruent with the tissue block/matrix interface. The histoculture system can be used to screen for antiviral drugs, to monitor the course of viral diseases, and to monitor an immune response to antigen stimulation.
    Type: Application
    Filed: April 1, 2003
    Publication date: October 30, 2003
    Inventors: Robert M. Hoffman, Leonid B. Margolis
  • In vitro model for HIV and other viral diseases
    Patent number: 6562586
    Abstract: An in vitro model system for viral infection is comprised of a tissue block from adult tonsil or lymph node supported on a matrix which is flexible and porous and wherin the supported tissue block is cultured in a medium whose surface is congruent with the tissue block/matrix interface. The histoculture system can be used to screen for antiviral drugs and to monitor the course of viral diseases.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: May 13, 2003
    Assignee: AntiCancer, Inc.
    Inventors: Robert M. Hoffman, Leonid B. Margolis, Joshua Zimmerberg, Svetlana Glushakova
  • Model for viral infection and immune response
    Patent number: 6551772
    Abstract: An in vitro model system for viral infection and for immune response is comprised of a tissue block from adult tonsil or lymph node supported on a matrix which is flexible and porous and wherein the supported tissue block is cultured in a medium whose surface is congruent with the tissue block/matrix interface. The histoculture system can be used to screen for antiviral drugs, to monitor the course of viral diseases, and to monitor an immune response to antigen stimulation.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: April 22, 2003
    Assignee: AntiCancer, Inc.
    Inventors: Robert M. Hoffman, Leonid B. Margolis