Patents by Inventor Leonid Breydo

Leonid Breydo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of formation of amyloid b-protein fibrils using cactus mucilage extracts
    Patent number: 10946056
    Abstract: A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of A? fibrils and aggregation of A? fibrils into plaques.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: March 16, 2021
    Assignee: University of South Florida
    Inventors: Norma A. Alcantar, David Morgan, Zeinab Veisi, Leonid Breydo, Vladimir N. Uversky, Ryan G. Toomey, Tunan Peng, Eva Stephanie Lobbens
  • INHIBITION OF FORMATION OF AMYLOID B-PROTEIN FIBRILS USING CACTUS MUCILAGE EXTRACTS
    Publication number: 20190328811
    Abstract: A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of A? fibrils and aggregation of A? fibrils into plaques.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 31, 2019
    Applicant: University of South Florida
    Inventors: Norma A. Alcantar, David Morgan, Zeinab Veisi, Leonid Breydo, Vladimir N. Uversky, Ryan G. Toomey, Tunan Peng, Eva Stephanie Lobbens
  • Inhibition of formation of amyloid ?-protein fibrils using cactus mucilage extracts
    Patent number: 10391135
    Abstract: A method of treating an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of A? fibrils and aggregation of A? fibrils into plaques.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: August 27, 2019
    Assignee: University of South Florida
    Inventors: Norma A. Alcantar, David Morgan, Zeinab Veisi, Leonid Breydo, Vladimir N. Uversky, Ryan G. Toomey, Tunan Peng, Eva Stephanie Lobbens
  • INHIBITION OF FORMATION OF AMYLOID B-PROTEIN FIBRILS USING CACTUS MUCILAGE EXTRACTS
    Publication number: 20180078595
    Abstract: Alzheimer' s disease (AD) is the common neurodegenerative disorder characterized by the formation of extraneuronal accumulation of amyloid fibrils and intracellular neurofibrillary tangles of Amyloid ?-Protein (A?) into plaques. Cactus mucilage extracted from Opuntia ficus-indica was analyzed in disturbing the aggregation pathway of Amyloid ?-Protein (A?) fibrils and ?-synuclein. Mucilage is a pectin polysaccharide with a backbone of ?-D-galacturonic acid and ?-L-rhamnose and a branch of arabinose or xylose. Two different fractions of mucilage can be extracted: pectin gelling extract which forms gels in the presence of Ca2+ ions (GE) and non-gelling extract (NE). The effectiveness of mucilage in disturbing the formation of A? fibrils was evaluated. A? monomeric species have been incubated along with different concentration of the mucilage extract in vitro. The aggregation kinetics of the A? proteins were monitored by Fourier transform infrared (FTIR) spectroscopy.
    Type: Application
    Filed: September 15, 2017
    Publication date: March 22, 2018
    Applicant: University of South Florida
    Inventors: Norma A. Alcantar, David Morgan, Zeinab Veisi, Leonid Breydo, Vladimir N. Uversky, Ryan G. Toomey, Tunan Peng, Eva Stephanie Lobbens