Patents by Inventor Leonid Gitlin

Leonid Gitlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alphavirus neoantigen vectors
    Patent number: 11504421
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: November 22, 2022
    Assignee: GRITSTONE BIO, INC.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • MULTIEPITOPE VACCINE CASSETTES
    Publication number: 20220265797
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: April 22, 2022
    Publication date: August 25, 2022
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane
  • HIV ANTIGENS AND MHC COMPLEXES
    Publication number: 20220265812
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines against infectious diseases such as HIV.
    Type: Application
    Filed: December 29, 2021
    Publication date: August 25, 2022
    Inventors: Roman Yelensky, James Xin Sun, Joshua Klein, Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • Alphavirus neoantigen vectors
    Patent number: 11419929
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: August 23, 2022
    Assignee: GRITSTONE BIO, INC.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Alphavirus Antigen Vectors
    Publication number: 20220226453
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: March 11, 2022
    Publication date: July 21, 2022
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • ALPHAVIRUS NEOANTIGEN VECTORS AND INTERFERON INHIBITORS
    Publication number: 20220125919
    Abstract: Disclosed herein are vectors that include alphavirus-based expression platforms. Also disclosed are methods associated with the alphavirus-based expression platforms and co-administration of an inhibitor of Type I interferon signaling.
    Type: Application
    Filed: November 7, 2019
    Publication date: April 28, 2022
    Inventors: Karin Jooss, Amy Rachel Rappaport, Leonid Gitlin
  • MODIFIED ADENOVIRUSES
    Publication number: 20220090138
    Abstract: Disclosed herein are compositions that include modified adenoviruses. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines. Also disclosed herein are viral vectors using TET promoter system and methods of producing viruses having the same.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 24, 2022
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • IMMUNE CHECKPOINT INHIBITOR CO-EXPRESSION VECTORS
    Publication number: 20210213122
    Abstract: Disclosed herein are vectors that include antigen-encoding nucleic acid sequences and co-express immune modulators. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: May 23, 2019
    Publication date: July 15, 2021
    Applicant: Gritstone Oncology, Inc.
    Inventors: Wade Blair, Karin Jooss, Leonid Gitlin, Ciaran Daniel Scallan, Amy Rachel Rappaport, Gijsbert Grotenbreg
  • ALPHAVIRUS NEOANTIGEN VECTORS
    Publication number: 20200197500
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: May 8, 2018
    Publication date: June 25, 2020
    Inventors: Wade BLAIR, Karin JOOSS, Amy Rachel RAPPAPORT, Ciaran Daniel SCALLAN, Leonid GITLIN
  • VIRAL DELIVERY OF NEOANTIGENS
    Publication number: 20200010849
    Abstract: Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: November 22, 2017
    Publication date: January 9, 2020
    Inventors: Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Adnan Derti, Leonid Gitlin, Gijsbert Grotenbreg, Karin Jooss, Ciaran Daniel Scallan, Roman Yelensky