Patents by Inventor Leonid Kruglyak

Leonid Kruglyak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230279505
    Abstract: In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.
    Type: Application
    Filed: December 8, 2022
    Publication date: September 7, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Elaine Ostrander, Leonid Kruglyak, Heidi G. Parker, Lisa V. Kim, Matthew Stephens, Tiffany B. Malek, Nathan B. Sutter, Scott Carlson
  • Publication number: 20110224911
    Abstract: In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.
    Type: Application
    Filed: March 2, 2011
    Publication date: September 15, 2011
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Elaine Ostrander, Leonid Kruglyak, Heidi G. Parker, Lisa V. Kim, Matthew Stephens, Tiffany B. Malek, Nathan B. Sutter, Scott Carlson
  • Publication number: 20100217534
    Abstract: In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.
    Type: Application
    Filed: April 27, 2010
    Publication date: August 26, 2010
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Elaine Ostrander, Leonid Kruglyak, Heidi G. Parker, Lisa V. Kim, Matthew Stephens, Tiffany B. Malek, Nathan B. Sutter, Scott Carlson
  • Patent number: 7729863
    Abstract: In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: June 1, 2010
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Elaine Ostrander, Leonid Kruglyak, Heidi G Parker, Lisa V Kim, Matthew Stephens, Tiffany B Malek, Nathan B Sutter, Scott Carlson
  • Publication number: 20090264307
    Abstract: Disclosed herein is a system useful for detecting sequence differences (e.g., single-nucleotide polymorphisms) between genomes using data from a single hybridization with a genomic DNA microarray, such as a whole-genome array. The methods described herein can be used to detect, simply and inexpensively, differences in sequence among the genomes of individual members of a species, for example. In examples described herein, the system and methods were used to detect a variety of spontaneous single base-pair substitutions, insertions and deletions, and most (>90%) of the approximately 30,000 known single-nucleotide polymorphisms between two Saccharomyces cerevisiae strains. The system and methods were also used to elucidate the genetic basis of phenotypic variants and identify the small number of single base-pair changes accumulated during experimental evolution of yeast.
    Type: Application
    Filed: January 12, 2007
    Publication date: October 22, 2009
    Applicant: The Trustees of Princeton University
    Inventors: David Gresham, David Botstein, Leonid Kruglyak, Douglas Ruderfer, Stephen Pratt
  • Publication number: 20060235625
    Abstract: In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.
    Type: Application
    Filed: December 15, 2004
    Publication date: October 19, 2006
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Elaine Ostrander, Leonid Kruglyak, Heidi Parker, Lisa Kim, Mathew Stephens, Tiffany Malek, Nathan Sutter, Scott Carlson