Patents by Inventor Leonid Margolis

Leonid Margolis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for the treatment of viral infection
    Patent number: 8946243
    Abstract: The invention relates to compounds and methods for treating or preventing a viral infection, by administering a monophosphorylated prodrug of acyclovir or monophosphorylated derivative of an acyclovir prodrug to a subject suffering from or susceptible (to a viral infection, such as HIV infection.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: February 3, 2015
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Katholieke Universiteit Leuven
    Inventors: Leonid Margolis, Jan Balzarini, Christopher McGuigan, Andrea Lisco, Christophe Vanpouille, Marco Derudas
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRAL INFECTION
    Publication number: 20110184003
    Abstract: The invention relates to compounds and methods for treating or preventing a viral infection, by administering a monophosphorylated prodrug of acyclovir or monophosphorylated derivative of an acyclovir prodrug to a subject suffering from or susceptible (to a viral infection, such as HIV infection.
    Type: Application
    Filed: March 27, 2009
    Publication date: July 28, 2011
    Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH
    Inventors: Leonid Margolis, Jan Balzarini, Christopher McGuigan, Andrea Lisco, Christophe Vanpouille, Marco Derudas
  • Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit ccr5-tropic hiv-1 infection and replication
    Publication number: 20050123510
    Abstract: It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
    Type: Application
    Filed: March 28, 2002
    Publication date: June 9, 2005
    Applicant: The Government of the United States, as represent- ed by the Secretary of Health and Human Services,
    Inventors: Leonid Margolis, Jean-Charles Grivel, Paolo Lusso