Patents by Inventor Leonid Matsiev
Leonid Matsiev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040074303Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a cantilever, connected to a measurement circuit. The mechanical resonator can be covered with a coating to impart additional special detection propertied to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.Type: ApplicationFiled: October 15, 2003Publication date: April 22, 2004Applicant: Symyx Technologies, IncInventors: Leonid Matsiev, James Bennett, Eric McFarland
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Publication number: 20040074302Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a cantilever, connected to a measurement circuit. The mechanical resonator can be covered with a coating to impart additional special detection propertied to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.Type: ApplicationFiled: October 15, 2003Publication date: April 22, 2004Applicant: Symyx Technologies, Inc.Inventors: Leonid Matsiev, James Bennett, Eric McFarland
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Patent number: 6690179Abstract: One aspect of the present invention provides instruments for measuring mechanical properties of a combinatorial library of materials. The instruments include at least one capacitor to which a member of a library of material samples is removably secured for testing; at least one voltage source for delivering one or more forces to each library member; and at least one sensing device for monitoring the response each library member to the one or more forces. Another aspect of the present invention provides methods of screening a combinatorial library of materials where the method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.Type: GrantFiled: August 24, 2001Date of Patent: February 10, 2004Assignee: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Publication number: 20030218467Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.Type: ApplicationFiled: May 24, 2002Publication date: November 27, 2003Applicant: Symyx Technologies, Inc.Inventors: Eric D. Carlson, Oleg Kolosov, Leonid Matsiev, Laura T. Mazzola, Mikhail Spitkovsky, John Gallipeo
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Patent number: 6650102Abstract: The present invention provides instruments and methods for screening combinatorial libraries that addresses many of the problems encountered when using conventional instruments. For example, the disclosed instruments can measure mechanical properties of library members in rapid serial or parallel test format, and can perform tests on small amounts of material, which are easily prepared or dispensed using art-disclosed liquid or solid handling techniques. Compared to conventional instruments, the disclosed instruments afford faster sample loading and unloading, for example, through the use of disposable libraries of material samples.Type: GrantFiled: August 24, 2001Date of Patent: November 18, 2003Assignee: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Publication number: 20030190755Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: ApplicationFiled: March 25, 2003Publication date: October 9, 2003Applicant: Symyx Technologies, Inc.Inventors: Howard Turner, G. Cameron Dales, Lynn VanErden, Johannes A.M. VanBeek, Damian A. Hajduk, Ralph B. Nielsen, Paul Mansky, Leonid Matsiev, Pei Wang, Eric McFarland
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Publication number: 20030157721Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: ApplicationFiled: August 28, 2002Publication date: August 21, 2003Applicant: Symyx Technologies, Inc.Inventors: Howard Turner, G. Cameron Dales, Lynn vanErden, Johannes A.M. van Beek, Damian A. Hajduk, Ralph B. Nielsen, Paul Mansky, Leonid Matsiev, Pei Wang, Eric McFarland
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Publication number: 20030127776Abstract: A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. Providing the plurality of samples can include a variety of sample formation techniques including, but not limited to, extruding, milling, compression preparation, rotary mixing, microcentrifugation, molding and casting. Preferably, the samples are solidified into a near net shape configuration appropriate for testing of properties or characteristics of the samples.Type: ApplicationFiled: November 8, 2002Publication date: July 10, 2003Applicant: Symyx Technologies, Inc.Inventors: Eric D. Carlson, Damian A. Hajduk, Leonid Matsiev, Adam Safir, Paul Mansky
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Publication number: 20030070917Abstract: An apparatus including a basis that has a plurality of wells associated therewith for defining a plurality of electrochemical cells; at least two electrodes sealingly disposed in each electrochemical cell; and circuitry for providing an electrical connection between an electrical source and each said cell. A particularly preferred apparatus employs at least one printed circuit board secured to the base. In a preferred method, candidate materials are introduced into the apparatus and their respective performances are analyzed.Type: ApplicationFiled: October 11, 2001Publication date: April 17, 2003Applicant: Symyx Technologies, Inc.Inventors: Daniel M. Giaquinta, Alexander Gorer, Martin Devenney, Sum Nguyen, Leonid Matsiev
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Publication number: 20030041672Abstract: A method for high throughput mechanical property and bulge testing of materials libraries. A plurality of samples on a substrate are monitored for their response to a force from a fluid.Type: ApplicationFiled: August 24, 2001Publication date: March 6, 2003Applicant: Symyx Technologies , Inc.Inventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Publication number: 20030041676Abstract: A method for high throughput mechanical property testing of materials libraries using a piezoelectric. A plurality of samples on a substrate are monitored for their response to a force applied piezoelectrically.Type: ApplicationFiled: August 24, 2001Publication date: March 6, 2003Applicant: SYMYX Technologies, Inc.Inventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Publication number: 20030041671Abstract: A method for high throughput mechanical property testing of materials libraries using capacitance. The method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.Type: ApplicationFiled: August 24, 2001Publication date: March 6, 2003Applicant: Symyx Technologies, IncInventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Publication number: 20030045000Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber is disclosed. The apparatus includes a reaction chamber for receiving one or more libraries, each of the libraries comprising two or more samples. The reaction chamber is configured to form a sealed enclosure. The apparatus further includes an injection manifold supporting injectors for in-situ injection of one or more chemical components onto respective samples of the one or more libraries in the pressurized sealed reaction chamber.Type: ApplicationFiled: June 28, 2002Publication date: March 6, 2003Applicant: SYMYX TECHNOLOGIES, INC.Inventors: Trevor G. Frank, Keith A. Hall, William H. Chandler, Thomas Boussie, Thomas J. Crevier, Leonid Matsiev, Christopher Goh
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Publication number: 20030041653Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties.Type: ApplicationFiled: October 7, 2002Publication date: March 6, 2003Applicant: Symyx Technologies, Inc.Inventors: Leonid Matsiev, James Bennett, Eric McFarland
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Patent number: 6528026Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: GrantFiled: November 19, 1998Date of Patent: March 4, 2003Assignee: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Ralph B. Nielsen, Adam Safir, Leonid Matsiev, Eric McFarland, Paul Mansky
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Publication number: 20030026736Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: ApplicationFiled: April 29, 2002Publication date: February 6, 2003Applicant: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Ralph B. Nielsen, Adam Safir, Leonid Matsiev, Eric McFarland, Paul Mansky
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Publication number: 20030000291Abstract: An improved system, device and method for characterizing a fluid sample that includes injecting a fluid sample into a mobile phase of a flow characterization system, and detecting a property of the fluid sample or of a component thereof with a flow detector comprising a mechanical resonator, preferably one that is operated at a frequency less than about 1 MHz, such as a tuning fork resonator.Type: ApplicationFiled: June 5, 2002Publication date: January 2, 2003Applicant: Symyx Technologies, Inc.Inventors: Oleg Kolosov, Leonid Matsiev, Miroslav Petro
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Patent number: 6494079Abstract: A method and apparatus for measuring properties of a fluid composition in a conduit includes a mechanical resonator connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the mechanical resonator, causing the mechanical resonator to oscillate. The input signal is then sent to the mechanical resonator and swept over a selected frequency range. The mechanical resonator's response over the frequency range depends on various characteristics of the fluid being tested, such as the temperature, viscosity, and other physical properties.Type: GrantFiled: March 7, 2001Date of Patent: December 17, 2002Assignee: Symyx Technologies, Inc.Inventors: Leonid Matsiev, James Bennett, Eric McFarland
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Publication number: 20020178787Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties.Type: ApplicationFiled: July 23, 2002Publication date: December 5, 2002Applicant: Symyx Technologies, Inc.Inventors: Leonid Matsiev, James Bennett, Eric McFarland
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Publication number: 20020155036Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: ApplicationFiled: April 29, 2002Publication date: October 24, 2002Applicant: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Ralph B. Nielsen, Adam Safir, Leonid Matsiev, Eric McFarland, Paul Mansky