Patents by Inventor Leonid Metsger

Leonid Metsger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes and intermediates for the preparation of Pimavanserin
    Patent number: 10807953
    Abstract: The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: October 20, 2020
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Tomislav Biljan, Jasna Dogan, Leonid Metsger, Sara Morasi Pipercic, Marina Ratkaj, Maja Matanovic Skugor, Yi Wang
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIMAVANSERIN
    Publication number: 20190276401
    Abstract: The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
    Type: Application
    Filed: May 28, 2019
    Publication date: September 12, 2019
    Inventors: Tomislav BILJAN, Jasna DOGAN, Leonid METSGER, Sara Morasi PIPERCIC, Marina RATKAJ, Maja Matanovic SKUGOR, Yi WANG
  • Processes and intermediates for the preparation of Pimavanserin
    Patent number: 10343993
    Abstract: The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: July 9, 2019
    Assignee: Pliva Hrvatska d.o.o.
    Inventors: Tomislav Biljan, Jasna Dogan, Leonid Metsger, Sara Morasi Pipercic, Marina Ratkaj, Maja Matanovic Skugor, Yi Wang
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIMAVANSERIN
    Publication number: 20180037549
    Abstract: The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
    Type: Application
    Filed: March 2, 2016
    Publication date: February 8, 2018
    Inventors: Tomislav BILJAN, Jasna DOGAN, Leonid METSGER, Sara Morasi PIPERCIC, Marina RATKAJ, Maja Matanovic SKUGOR, Yi WANG
  • Crystalline forms of febuxostat
    Patent number: 8742129
    Abstract: New forms of Febuxostat have bean, prepared and characterized. These forms are useful for examples in the chronic management of hyperuricemia in patients with gout.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: June 3, 2014
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Maytal Piran, Leonid Metsger
  • Crystalline forms of Febuxostat
    Patent number: 8609856
    Abstract: New forms of Febuxostat have been prepared and characterized. These forms are useful, for example, in the chronic management of hyperuricemia in patients with gout.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: December 17, 2013
    Assignee: Teva Pharmaceuticals USA, Inc.
    Inventors: Maytal Piran, Leonid Metsger
  • CRYSTALLINE FORMS OF FEBUXOSTAT
    Publication number: 20130245077
    Abstract: New forms of Febuxostat have bean, prepared and characterized. These forms are useful for examples in the chronic management of hyperuricemia in patients with gout.
    Type: Application
    Filed: March 1, 2013
    Publication date: September 19, 2013
    Applicant: TEVA PHARMACEUTICALS INDUSTRIES LTD.
    Inventors: Maytal PIRAN, Leonid METSGER
  • SOLID STATE FORMS OF LINAGLIPTIN
    Publication number: 20130123282
    Abstract: The present invention provides solid state forms of Linagliptin, processes for preparing the solid state forms, and pharmaceutical compositions thereof.
    Type: Application
    Filed: November 15, 2012
    Publication date: May 16, 2013
    Inventors: Leonid Metsger, Revital Burstein, Ariel Mitteman, Motti Erlich, Slavik Yurkovsky
  • Crystalline form of febuxostat
    Patent number: 8415481
    Abstract: New forms of Febuxostat have been prepared and characterized. These forms are useful, for example, in the chronic management of hyperuricemia in patients with gout.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: April 9, 2013
    Assignee: Teva Pharmaceuticals USA, Inc.
    Inventors: Maytal Piran, Leonid Metsger
  • FORMS OF LAPATINIB DITOSYLATE AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20120289701
    Abstract: The present invention provides novel polymorphs of lapatinib ditosylate, processes for preparing them, and pharmaceutical compositions comprising one or more of these polymorphs.
    Type: Application
    Filed: July 24, 2012
    Publication date: November 15, 2012
    Inventors: Leonid METSGER, Ariel MITTELMAN, Slavik YURKOVSKI
  • Forms of lapatinib ditosylate and processes for preparation thereof
    Patent number: 8252805
    Abstract: The present invention provides novel polymorphs of lapatinib ditosylate, processes for preparing them, and pharmaceutical compositions comprising one or more of these polymorphs.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: August 28, 2012
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Leonid Metsger, Ariel Mittelman, Slavik Yurkovski
  • Crystalline forms of tigecycline and processes for preparation thereof
    Patent number: 8198469
    Abstract: The present invention provides crystalline forms of Tigecycline, and methods of for preparation of crystalline forms and amorphous.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: June 12, 2012
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Evgeny Tsiperman, Sofia Gorohovsky-Rosenberg, Slavik Yurkovski, Sergei Fine, Tamás Koltai, Sigalit Levi, Leonid Metsger, Michal Rafilovich
  • Crystalline form II of tigecycline and processes for preparation thereof
    Patent number: 8198470
    Abstract: The present invention provides processes for the preparation of crystalline forms of Tigecycline.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: June 12, 2012
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Sigalit Levi, Michal Rafilovich, Sofia Gorohovsky-Rosenberg, Slavik Yurkovski, Sergei Fine, Leonid Metsger, Evgeny Tsiperman
  • CRYSTALLINE FORM OF FEBUXOSTAT
    Publication number: 20100317702
    Abstract: New forms of Febuxostat have been prepared and characterized. These forms are useful, for example, in the chronic management of hyperuricemia in patients with gout.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Maytal PIRAN, Leonid METSGER
  • LAPATINIB INTERMEDIATES
    Publication number: 20100197915
    Abstract: The invention provides lapatinib intermediates and improved processes for preparing lapatinib intermediates. The invention also provides processes for preparing lapatinib base and lapatinib ditosylate.
    Type: Application
    Filed: August 6, 2009
    Publication date: August 5, 2010
    Inventors: Leonid METSGER, Slavik YURKOVSKI, Sofia GOROHOVSKY-ROSENBERG, Noa KIPNIS, Dikla LAVY
  • CRYSTALLINE FORM II OF TIGECYCLINE AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20100152142
    Abstract: The present invention provides processes for the preparation of crystalline forms of Tigecycline.
    Type: Application
    Filed: December 1, 2008
    Publication date: June 17, 2010
    Inventors: Sigalit Levi, Michal Rafilovich, Sofia Gorohovsky-Rosenberg, Slavik Yurkovski, Sergei Fine, Leonid Metsger, Evgeny Tsiperman
  • FORMS OF LAPATINIB COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF
    Publication number: 20100087459
    Abstract: The present invention provides novel crystalline and amorphous lapatinib compounds and processes for preparing them
    Type: Application
    Filed: August 26, 2009
    Publication date: April 8, 2010
    Inventors: Leonid METSGER, Ariel MITTELMAN, Slavik YURKOVSKI
  • FORMS OF CRYSTALLINE LAPATINIB AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20090306106
    Abstract: The present invention provides new crystalline forms of lapatinib base, Form X and Form Y, and amorphous lapatinib base, pharmaceutical compositions comprising the new crystalline forms of lapatinib base, and/or the amorphous lapatinib base, and processes for their preparation.
    Type: Application
    Filed: May 7, 2009
    Publication date: December 10, 2009
    Inventors: Leonid METSGER, Ariel MITTELMAN, Slavik YURKOVSKI
  • FORMS OF LAPATINIB DITOSYLATE AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20090281315
    Abstract: The present invention provides novel polymorphs of lapatinib ditosylate, processes for preparing them, and pharmaceutical compositions comprising one or more of these polymorphs.
    Type: Application
    Filed: May 7, 2009
    Publication date: November 12, 2009
    Inventors: Leonid METSGER, Ariel MITTELMAN, Slavik YURKOVSKI
  • Crystalline forms of tigecycline and processes for preparation thereof
    Publication number: 20090005453
    Abstract: The present invention provides crystalline forms of Tigecycline, and methods of for preparation of crystalline forms and amorphous.
    Type: Application
    Filed: November 29, 2007
    Publication date: January 1, 2009
    Inventors: Evgeny Tsiperman, Sofia Gorohovsky-Rosenberg, Slavik Yurkovski, Sergei Fine, Tamas Koltai, Sigalit Levi, Leonid Metsger, Michal Rafilovich