Patents by Inventor Leonid Z. Iakoubov

Leonid Z. Iakoubov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETING OF NEUTROPHIL EXTRACELLULAR TRAPS AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF
    Publication number: 20240075156
    Abstract: The present disclosure provides compositions for targeting neutrophil extracellular traps for diagnostic and therapeutic purposes (e.g., for treating inflammation in conditions or diseases associated with accumulation of neutrophil extracellular traps in a subject in need thereof).
    Type: Application
    Filed: December 6, 2021
    Publication date: March 7, 2024
    Inventors: Vladimir Torchilin, Leonid Z. Iakoubov, Nina Filipczak, Livia Palmerston Mendes
  • Identification of Polymorphisms and Their Use as Markers for Disease Susceptibility, Diagnosis and Treatment Optimization
    Publication number: 20130195880
    Abstract: Provided are methods and kits to determine whether a subject is predisposed to developing a disease or condition associated with structural polymorphisms in genes CNTNAP2 and CNTNAP4, along with the methods to optimize treatment with various pharmaceutical preparations which modulate ion channels, neurite outgrowth, and myelination signaling.
    Type: Application
    Filed: August 5, 2010
    Publication date: August 1, 2013
    Inventors: Leonid Z. Iakoubov, Henry Wilfred Lopez, Steven Patrick Noonan
  • Nucleosome-based anti-tumor compositions
    Publication number: 20020151517
    Abstract: A method of inhibiting neoplastic cell growth in a mammal by administering to the mammal nucleosomes that elicit the production of antinuclear autoantibodies sufficient to inhibit neoplastic cell growth.
    Type: Application
    Filed: April 9, 2002
    Publication date: October 17, 2002
    Applicant: The General Hospital Corporation, a Massachusetts corporation
    Inventors: Vladimir P. Torchilin, Leonid Z. Iakoubov
  • Biologically active proteins
    Publication number: 20020120109
    Abstract: Methods are disclosed for preparing biologically active protein conjugates using negatively charged polymers that protect the protein within the conjugate so that it retains a substantial amount of its biological activity following conjugation (e.g., procedure in which a protein is conjugated to a pharmaceutical agent, a solid support, a reporter molecule, a group carrying a reporter molecule, an acylating agent, a chelating agent, a cross-linking agent, a targeting group, and a ligand and binding group). The invention also includes novel protein conjugates prepared by those methods.
    Type: Application
    Filed: July 6, 2001
    Publication date: August 29, 2002
    Inventors: Gennady P. Samokhin, Vladimir P. Torchilin, Leonid Z. Iakoubov, Dmitriy A. Mongayt
  • Nucleosome-based anti-tumor compositions
    Publication number: 20020119189
    Abstract: A method of inhibiting neoplastic cell growth in a mammal by administering to the mammal nucleosomes that elicit the production of antinuclear autoantibodies sufficient to inhibit neoplastic cell growth.
    Type: Application
    Filed: February 22, 2002
    Publication date: August 29, 2002
    Applicant: The General Hospital Corporation, a Massachusetts corporation
    Inventors: Vladimir P. Torchilin, Leonid Z. Iakoubov
  • NUCLEOSOME-BASED ANTI-TUMOR COMPOSITIONS
    Publication number: 20020013285
    Abstract: A method of inhibiting neoplastic cell growth in a mammal by administering to the mammal nucleosomes that elicit the production of antinuclear autoantibodies sufficient to inhibit neoplastic cell growth.
    Type: Application
    Filed: June 1, 1999
    Publication date: January 31, 2002
    Inventors: VLADIMIR P. TORCHILIN, LEONID Z. IAKOUBOV
  • NUCLEOSOME-BASED ANTI-TUMOR COMPOSITIONS
    Publication number: 20020009417
    Abstract: A method of inhibiting neoplastic cell growth in a mammal by administering to the mammal nucleosomes that elicit the production of antinuclear autoantibodies sufficient to inhibit neoplastic cell growth.
    Type: Application
    Filed: April 5, 1999
    Publication date: January 24, 2002
    Applicant: The General Hospital Corporation, a Massachusetts corporation
    Inventors: VLADIMIR P. TORCHILIN, LEONID Z. IAKOUBOV
  • Use of autoantibodies for tumor therapy and prophylaxis
    Patent number: 5993818
    Abstract: A method of inhibiting the growth of a tumor cell in a mammal by administering to the mammal an autoantibody, e.g, an antinuclear autoantibody from an aged mammal, that binds to either one or both of a surface of a tumor cell and a protein released from a dead tumor cell. Also disclosed are natural and monoclonal antinuclear autoantibodies from aged mammals and a hybridoma cell line producing a monoclonal antinuclear autoantibody.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: November 30, 1999
    Assignee: OncoLogic Biopharmaceuticals Corporation
    Inventors: Vladimir P. Torchilin, Leonid Z. Iakoubov
  • Use of autoantibodies for tumor therapy and prophylaxis
    Patent number: 5780033
    Abstract: A method of inhibiting the growth of a tumor cell in a mammal by administering to the mammal an autoantibody, e.g, an antinuclear autoantibody from an aged mammal, that binds to either one or both of a surface of a tumor cell and a protein released from a dead tumor cell. Also disclosed are natural and monoclonal antinuclear autoantibodies from aged mammals and a hybridoma cell line producing a monoclonal antinuclear autoantibody.
    Type: Grant
    Filed: November 22, 1995
    Date of Patent: July 14, 1998
    Inventors: Vladimir P. Torchilin, Leonid Z. Iakoubov