Abstract: The present methods use gene therapy to confer inducible nitric oxide synthase (iNOS) expression solely in the tumor space, using focused ultrasound targeting. NOS catalyzes the reaction that generates nitric oxide (NO), a potent endogenous vasodilator. Microbubble-mediated non-viral delivery overcomes major barriers associated with non-viral NO gene therapy. The methods increase tumor perfusion and compound the efficacy of a vast array of chemotherapy, radiotherapy, and immune-based treatments.

Abstract: The present disclosure relates to compositions, cells, and methods for authentication of cell lines using genetic physical unclonable functions.

Abstract: The disclosure relates to particle-based assays for the detection of analytes. Using various combinations of particular technologies, including gold nanorods, silver nanoparticles, gold/silver nanoshells, gold/silver nanocages and nanobubble detection, enhanced detection limits can be achieved across a large range of analytes.

Abstract: The present disclosure relates to vectors for the controlled expression transgenes and methods of use therefor.

Abstract: A system for embedding real-time Model Predictive Control (MPC) in a System-on-a-Chip (SoC) devices is provided. In the system, a microprocessor is connected to an auxiliary unit or application-specific matrix coprocessor. The microprocessor can control the operation of the MPC algorithm, i.e., carry out the tasks of input/output for the MPC algorithm, initialize and send the appropriate commands to auxiliary unit and receive back the optimal control moves or instructions from auxiliary unit. The auxiliary unit can operate as a matrix coprocessor by executing matrix operations, e.g. addition, multiplication, inversion, etc., required by the MPC algorithm.

Abstract: Disclosed herein are autonomous molecular circuits that can function in cells. The circuits can process logical operations in which one or more input cues are among the operands and produce an appropriate output. Such circuits can be implemented in living cells, e.g., eukaryotic or prokaryotic cells that have been modified to include circuit components. The molecular circuits and cells containing the circuits can be used in a variety of applications including, e.g., diagnostics, therapeutics, and protein production.

Abstract: A system for embedding real-time Model Predictive Control (MPC) in a System-on-a-Chip (SoC) devices is provided. In the system, a microprocessor is connected to an auxiliary unit or application-specific matrix coprocessor. The microprocessor can control the operation of the MPC algorithm, i.e., carry out the tasks of input/output for the MPC algorithm, initialize and send the appropriate commands to auxiliary unit and receive back the optimal control moves or instructions from auxiliary unit. The auxiliary unit can operate as a matrix coprocessor by executing matrix operations, e.g. addition, multiplication, inversion, etc., required by the MPC algorithm.