Patents by Inventor Leonie Jaspers

Leonie Jaspers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and sequences to preferentially suppress expression of mutated huntingtin
    Patent number: 9133517
    Abstract: Disclosed herein are methods and sequences to preferentially suppress the expression of the mutated huntingtin (“htt”) protein over expression of the normal htt protein. Also disclosed are methods comprising screening an individual for the heterozygous presence of one or more single nucleotide polymorphisms within the individual's Huntington's genes; administering nucleic acid molecules comprising nucleotide sequences that preferentially suppress the expression of amino acid sequences encoding for mutated huntingtin (“htt”) over suppressing the expression of amino acid sequences encoding for normal htt by targeting an area of a Huntington's disease gene that is heterozygous for the presence of one or more single nucleotide polymorphisms.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: September 15, 2015
    Assignee: Medtronics, Inc.
    Inventors: Paul H. J. Van Bilsen, Leonie Jaspers
  • METHODS AND KITS FOR LINKING POLYMORPHIC SEQUENCES TO EXPANDED REPEAT MUTATIONS
    Publication number: 20120172409
    Abstract: Methods and kits are provided for determining which single nucleotide polymorphism (“SNP”) variant of an allele of a heterozygous patient is on the same allele as a disease-causing mutation. Also, provided are kits for multi-SNP diagnosis and treatment, targeting combinations of SNPs having greater joint prevalence of heterozygosity in Huntington's population than individual SNPs considered individually.
    Type: Application
    Filed: May 22, 2008
    Publication date: July 5, 2012
    Applicant: MEDTRONIC, INC.
    Inventors: Paul van Bilsen, Eric N. Burright, William F. Kaemmerer, Leonie Jaspers, Maria Stella Lombardi
  • Methods And Sequences To Preferentially Suppress Expression of Mutated Huntingtin
    Publication number: 20100120900
    Abstract: Disclosed herein are methods and sequences to preferentially suppress the expression of the mutated huntingtin (“htt”) protein over expression of the normal htt protein. Also disclosed are methods comprising screening an individual for the heterozygous presence of one or more single nucleotide polymorphisms within the individual's Huntington's genes; administering nucleic acid molecules comprising nucleotide sequences that preferentially suppress the expression of amino acid sequences encoding for mutated huntingtin (“htt”) over suppressing the expression of amino acid sequences encoding for normal htt by targeting an area of a Huntington's disease gene that is heterozygous for the presence of one or more single nucleotide polymorphisms.
    Type: Application
    Filed: September 15, 2009
    Publication date: May 13, 2010
    Applicant: MEDTRONIC, INC.
    Inventors: Paul H.J. van Bilsen, Leonie Jaspers
  • Methods and sequences to preferentially suppress expression of mutated huntingtin
    Publication number: 20070161590
    Abstract: Disclosed herein are methods and sequences to preferentially suppress the expression of the mutated huntingtin (“htt”) protein over expression of the normal htt protein. Also disclosed are methods comprising screening an individual for the heterozygous presence of one or more single nucleotide polymorphisms within the individual's Huntington's genes; administering nucleic acid molecules comprising nucleotide sequences that preferentially suppress the expression of amino acid sequences encoding for mutated huntingtin (“htt”) over suppressing the expression of amino acid sequences encoding for normal htt by targeting an area of a Huntington's disease gene that is heterozygous for the presence of one or more single nucleotide polymorphisms.
    Type: Application
    Filed: June 28, 2006
    Publication date: July 12, 2007
    Applicant: Medtronic, Inc.
    Inventors: Paul Van Bilsen, Leonie Jaspers