Patents by Inventor Leonor KREMER BARÓN

Leonor KREMER BARÓN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies against CCR9 and methods of use thereof
    Patent number: 9884915
    Abstract: The present invention relates to antibodies binding specifically to CCR9, and to antigen-binding fragments thereof. It also relates to uses thereof and diagnostic methods using said antibodies.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: February 6, 2018
    Assignee: Consejo Superior de Investigaciones Cientificas C.S.I.C.
    Inventors: Sonia Chamorro Pérez, Ana Franco Villanueva, José Alberto García Sanz, Leonor Kremer Barón, Carlos Martínez Alonso, Maria Vela Cuenca, Laura Carramolino Fitera
  • ANTIBODIES AGAINST CCR9 AND APPLICATIONS THEREOF
    Publication number: 20160257756
    Abstract: The present invention relates to antibodies binding specifically to CCR9, and to antigen-binding fragments thereof. It also relates to uses thereof and diagnostic methods using said antibodies.
    Type: Application
    Filed: November 25, 2014
    Publication date: September 8, 2016
    Inventors: Sonia CHAMORRO PÉREZ, Ana FRANCO VILLANUEVA, José Alberto GARCÍA SANZ, Leonor KREMER BARÓN, Carlos MARTÍNEZ ALONSO, María VELA CUENCA, Laura CARRAMOLINO FITERA
  • Monoclonal antibody
    Patent number: 6716594
    Abstract: The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to hGH of molecular weight 22 kDa. The invention also relates to the use of this monoclonal antibody for measurement of hGH 20K, especially in body fluids. The antibodies can be used for detection and quantification of hGH 20K, especially in serum.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: April 6, 2004
    Assignees: Pharmacia Spain SA, Consejo Superior de Investigaciones Scientificas
    Inventors: Yngve Elof Hansson, Leonor Kremer Baron, Carlos Martínez Alonso, José Mario Mellado Garcia, José Miguel Rodriguez Frade
  • Method for determining cytokine receptor activation by the use of an antibody
    Patent number: 6645723
    Abstract: The present invention relates to a method for determinating cytokine receptor, especially growth hormone receptor (GHR), activation, by the use of an antibody capable of discriminating between an activated and an inactive cytokine receptor conformation, especially GHR or growth hormone binding protein (GHBP) conformation, the method comprising: contacting the antibody and the cytokine receptor to form a complex, contacting a candidate ligand to the complex, measuring the antibody binding to inactive cytokine receptor and thereby discriminating between an activated and an inactive conformation. The invention also relates to an antibody directed to the hinge spanning subdomains I and II of the growth hormone receptor extracellular region and which is capable of discriminating between an activated and an inactive receptor conformation. The invention also relates to the use of the antibody for e.g.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: November 11, 2003
    Assignees: Consejos Superior de Investigaciones Cientificas, Pharmacia Spain S.A.
    Inventors: Carlos Martinez Alonso, José Mario Mellado Garcia, Leonor Kremer Baron, José Miguel Rodriguez Frade
  • METHOD FOR DETERMINING CYTOKINE RECEPTOR ACTIVATION BY THE USE OF AN ANTIBODY
    Publication number: 20030077663
    Abstract: The present invention relates to a method for determinating cytokine receptor, especially growth hormone receptor (GHR), activation, by the use of an antibody capable of discriminating between an activated and an inactive cytokine receptor conformation, especially GHR or growth hormone binding protein (GHBP) conformation, the method comprising: contacting the antibody and the cytokine receptor to form a complex, contacting a candidate ligand to thc complex, measuring the antibody binding to inactive cytokine receptor and thereby discriminating between an activated and an inactive conformation
    Type: Application
    Filed: March 19, 1998
    Publication date: April 24, 2003
    Inventors: CARLOS MARTINEZ ALONSO, JOSE MARIO MELLADO GARCIA, LEONOR KREMER BARON, JOSE MIGUEL RODRIGUEZ FRADE
  • Method for determining cytokine receptor activation by the use of an antibody
    Patent number: 6495329
    Abstract: The present invention relates to a method for determinating cytokine receptor, especially growth hormone receptor (GHR), activation, by the use of an antibody capable of discriminating between an activated and an inactive cytokine receptor conformation, especially GHR or growth hormone binding protein (GHBP) conformation, the method comprising: contacting the antibody and the cytokine receptor to form a complex, contacting a candidate ligand to the complex, measuring the antibody binding to inactive cytokine receptor and thereby discriminating between an activated and an inactive conformation. The invention also relates to an antibody directed to the hinge spanning subdomains I and II of the growth hormone receptor extracellular region and which is capable of discriminating between an activated and an inactive receptor conformation. The invention also relates to the use of the antibody for e.g.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: December 17, 2002
    Assignees: Pharmacia AB, Consejo Superior de Investigaciones
    Inventors: Carlos Martinez Alonso, José Mario Mellado Garcia, Leonor Kremer Baron, José Miguel Rodriguez Frade
  • Monoclonal antibody
    Patent number: 5945296
    Abstract: The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to hGH of molecular weight 22 kDa. The invention also relates to the use of this monoclonal antibody for measurement of hGH 20K, especially in body fluids. The antibodies can be used for detection and quantification of hGH 20K, especially in serum.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: August 31, 1999
    Assignees: Pharmacia & Upjohn AB, Consejo Superior de Investigaciones
    Inventors: Yngve Elof Hansson, Leonor Kremer Baron, Carlos Martinez Alonso, Jose Mario Mellado Garcia, Jose Miguel Rodriguez Frade