Patents by Inventor Leonora Balaj

Leonora Balaj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9829483
    Abstract: The specification provides methods for isolating extracellular vesicles. Extracellular vesicles can be efficiently isolated, e.g., from biological fluids or cell culture media, using a heparin-coated solid support.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: November 28, 2017
    Assignee: The General Hospital Corporation
    Inventors: Leonora Balaj, Casey A. Maguire, Johan Skog, Xandra O. Breakefield
  • Publication number: 20160216253
    Abstract: The specification provides methods for isolating extracellular vesicles. Extracellular vesicles can be efficiently isolated, e.g., from biological fluids or cell culture media, using a heparin-coated solid support.
    Type: Application
    Filed: September 26, 2014
    Publication date: July 28, 2016
    Inventors: Leonora Balaj, Casey A. Maguire, Johan Skog, Xandra O. Breakefield
  • Publication number: 20160201121
    Abstract: Methods are disclosed herein for assaying a biological sample or a bodily fluid obtained from a subject by isolating, obtaining or using a microvesicle fraction from the biological sample or bodily fluid and detecting in the microvesicle fraction the presence or absence of a genetic aberration in an IDH1, TDH2, TP53, PTEN, CDKN2A, NF1, EGFR, RB1, PIK3CA, or BRAF gene. The methods may be used for aiding the diagnosis, prognosis, monitoring, or therapy selection in relation to a disease or other medical condition (e.g., a glioma) in a subject.
    Type: Application
    Filed: December 28, 2015
    Publication date: July 14, 2016
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Walter Chen, Xandra O. Breakefield, Leonora Balaj, Johan Karl Olov Skog
  • Publication number: 20160153053
    Abstract: Disclosed herein are methods for assaying a biological sample from a subject by analyzing components of microvesicle fractions in aid of risk, diagnosis, prognosis or monitoring of, or directing treatment of the subject for, a disease or other medical condition in the subject. Also disclosed are methods of treatment and identifying biomarkers using a microvesicle fraction of a subject. Kits, pharmaceutical compositions, and profiles related to the methods are also disclosed.
    Type: Application
    Filed: February 1, 2016
    Publication date: June 2, 2016
    Inventors: Johan Karl Olov SKOG, Leonora BALAJ, Mikkel NOERHOLM, Xandra O. BREAKEFIELD
  • Publication number: 20140147839
    Abstract: Methods are disclosed herein for assaying a biological sample or a bodily fluid obtained from a subject by isolating, obtaining or using a microvesicle fraction from the biological sample or bodily fluid and detecting in the microvesicle fraction the presence or absence of a genetic aberration in an IDH1, IDH2, TP53, PTEN, CDKN2A, NF1, EGFR, RB1, PIK3CA, or BRAF gene. The methods may be used for aiding the diagnosis, prognosis, monitoring, or therapy selection in relation to a disease or other medical condition (e.g., a glioma) in a subject.
    Type: Application
    Filed: October 17, 2011
    Publication date: May 29, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Walter Chen, Xandra O. Breakefield, Leonora Balaj, Johan Karl Olov Skog
  • Publication number: 20140045915
    Abstract: Disclosed herein are methods for assaying a biological sample from a subject by analyzing components of microvesicle fractions in aid of risk, diagnosis, prognosis or monitoring of or directing treatment of the subject for, a disease or other medical condition in the subject. Also disclosed are methods of treatment and identifying biomarkers using a microvesicle fraction of a subject. Kits, pharmaceutical compositions, and profiles related to the methods are also disclosed.
    Type: Application
    Filed: August 31, 2011
    Publication date: February 13, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Johan Karl Olov Skog, Leonora Balaj, Mikkel Noerholm, Xandra O. Breakefield