Patents by Inventor Leonore A. Herzenberg

Leonore A. Herzenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10503756
    Abstract: The described invention provides a method and/or system for analyzing data using population clustering through density based merging, and a method for guiding clustering strategy through entropy-based ranking score.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: December 10, 2019
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Stephen W. Meehan, Wayne A. Moore, Guenther Walther, Darya Orlova, Connor G. W. Meehan, David R. Parks, Leonore A. Herzenberg
  • Publication number: 20190360914
    Abstract: A method for defining distributions of functional subpopulations of cells in a cell population.
    Type: Application
    Filed: May 1, 2019
    Publication date: November 28, 2019
    Inventors: Stephen W. Meehan, Darya Y. Orlova, Wayne A. Moore, David R. Parks, Connor Meehan, Guenther Walther, Leonore A. Herzenberg
  • Patent number: 10452746
    Abstract: A method and apparatus for quantitatively measuring differences between portions of a multivariate, multi-dimensional sample distribution, may comprise summarizing the data by dividing the data into clusters each having a signature representative of a position of the cluster and a fraction of the entire distribution within the cluster; matching a plurality of first supplier signatures to a respective one of a plurality of second receiver signatures using a cost factor indicative of the separation between first signature elements and second signature elements; and determining a measurement of the work required to transform the first signature to the second signature. The step of determining a measurement of the work may comprise applying the earth mover distance (“EMD”) algorithm between the first signature or elements of the first signature and the respective second signatures or elements of the respective second signature.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: October 22, 2019
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Leonore A. Herzenberg, Guenther Walther, Wayne A. Moore, Noah Zimmerman
  • Patent number: 10379118
    Abstract: The described invention provides a method for quantifying cellular antigens that is independent of specially prepared calibration beads and antibody reagents. The described method can be applied to both low and high affinity antibodies, under both saturating and non-saturating binding conditions.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: August 13, 2019
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Darya Y. Orlova, David R. Parks, Leonore A. Herzenberg, Andrei V. Chernyshev, Alexander E. Moskalensky
  • Patent number: 10235429
    Abstract: The invention describes a system and method for searching, organizing and displaying information in a user-specified flexible context that enables users to create customized hierarchical views and groupings. The formats for acquiring search results may be stored so that they may be re-applied to the same data or any similarly structured data in subsequent sessions.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: March 19, 2019
    Inventors: Stephen W. Meehan, Leonore Herzenberg, Stephan M. Weissman
  • Publication number: 20190050408
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Application
    Filed: December 8, 2016
    Publication date: February 14, 2019
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinhui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • Patent number: 10114012
    Abstract: Methods for detecting nonactivated basophils in a whole blood sample obtained from a normal healthy subject, methods for determining a subject's susceptibility to an allergic reaction to an allergen, where the subject has no known allergy to the allergen, methods for measuring a response to challenge with a potential allergen in a whole blood sample obtained from a subject with known allergic reactivity to allergens other than the potential allergen; and an in vitro system for reliable detection or quantification of a specific white blood cell population in a whole blood sample are described.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: October 30, 2018
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Yael Gernez, Leonore A. Herzenberg, Kari Nadeau, Rabindra Tirouvanziam
  • Publication number: 20180052162
    Abstract: The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.
    Type: Application
    Filed: April 17, 2017
    Publication date: February 22, 2018
    Inventors: David B. Miklos, Bita Sahaf, Leonore A. Herzenberg
  • Patent number: 9891213
    Abstract: Methods are provided for determining a subject's susceptibility to an allergic reaction upon exposure to an offending allergen.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: February 13, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yael Gernez, Leonore A. Herzenberg, Kari Nadeau, Rabindra Tirouvanziam
  • Publication number: 20180018386
    Abstract: Some embodiments provide methods, systems and computer-readable media that employ adaptive binning and dissimilarity scores based on a quadratic form distance for multidimensional data for matching clusters in data corresponding to different sample. Some embodiments provide methods, systems and computer-readable media for rendering a first interactive display including a two-dimensional plot of at least a portion of a multidimensional data set and a corresponding second interactive display including a plurality of single parameter charts or histograms, each displaying information corresponding to one-dimensional measurements of a different parameter in the multidimensional data set.
    Type: Application
    Filed: July 17, 2017
    Publication date: January 18, 2018
    Inventors: Darya Y. Orlova, Stephen W. Meehan, Wayne A. Moore, Guenther Walther, David R. Parks, Leonore A. Herzenberg
  • Patent number: 9658228
    Abstract: The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: May 23, 2017
    Assignee: The Board of Trustees of the Leland University Junior University
    Inventors: David B. Miklos, Bita Sahaf, Leonore A. Herzenberg
  • Publication number: 20170091199
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Application
    Filed: December 8, 2016
    Publication date: March 30, 2017
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinjui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • Publication number: 20170091282
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Application
    Filed: December 13, 2016
    Publication date: March 30, 2017
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinjui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • Patent number: 9552416
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: January 24, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinhui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • Publication number: 20160238597
    Abstract: The described invention provides a method for quantifying cellular antigens that is independent of specially prepared calibration beads and antibody reagents. The described method can be applied to both low and high affinity antibodies, under both saturating and non-saturating binding conditions.
    Type: Application
    Filed: February 10, 2016
    Publication date: August 18, 2016
    Inventors: Darya Y. Orlova, David R. Parks, Leonore A. Herzenberg, Andrei V. Chernyshev, Alexander E. Moskalensky
  • Patent number: 9164108
    Abstract: This invention provides novel liposome-based articles of manufacture and microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, and (3) to determine whether a subject is afflicted with a disorder. This invention also provides kits which comprise the instant microarrays.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: October 20, 2015
    Assignee: SRI INTERNATIONAL
    Inventors: Denong Wang, Leonore A. Herzenberg, Lawrenes Steinman
  • Publication number: 20150293992
    Abstract: The described invention provides a method and/or system for analyzing data using population clustering through density based merging, and a method for guiding clustering strategy through entropy-based ranking score.
    Type: Application
    Filed: April 20, 2015
    Publication date: October 15, 2015
    Inventors: Stephen W. Meehan, Wayne A. Moore, Guenther Walther, Darya Y. Orlova, Connor G.W. Meehan, David R. Parks, Leonore A. Herzenberg
  • Publication number: 20140212378
    Abstract: The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.
    Type: Application
    Filed: March 12, 2013
    Publication date: July 31, 2014
    Inventors: David B. Miklos, Bita Sahaf, Leonore A. Herzenberg
  • Patent number: 8731844
    Abstract: The invention provides a system and method for selecting an optimal multimarker reagent combination for the identification and/or quantification of molecules in or on cells with or without reference to fluorescence or other properties of at least one fluorescent dye or other instrument-measurable atom or molecule associated directly or indirectly with the reagent combination. The method includes specifying, using a computer, a plurality of markers to be detected by a plurality of reagents, generating, using a computer, a plurality of reagent combinations comprising the plurality of reagents to detect the plurality of markers, wherein the reagent combinations are ranked according to at least one user-defined or system-defined criterion, and selecting the optimal reagent combination or providing a rank-ordered list of combinations.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: May 20, 2014
    Inventors: Leonore A. Herzenberg, David Rhodes Parks, Stephen Meehan, Wayne A. Moore
  • Publication number: 20130317107
    Abstract: The described invention provides methods for treating a disease, disorder or condition comprising an inflammatory component that includes a platelet dysfunction component and methods for monitoring therapeutic efficacy of a therapeutic regimen for managing a disease comprising an inflammatory component that includes platelet dysfunction.
    Type: Application
    Filed: March 13, 2013
    Publication date: November 28, 2013
    Inventors: Leonore A. Herzenberg, Rabin Tirouvanziam, Tetyana Obukhanyck, Yael Gernerz