Patents by Inventor Lepei CHEN

Lepei CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid nano drug delivery system targeting brain lesion and preparation method and application thereof
    Patent number: 12611379
    Abstract: A lipid nano drug delivery system targeting a brain lesion and a preparation method and application thereof. The drug delivery system comprises a lipid, a delivery drug, and a functional penetrating peptide, and the functional penetrating peptide is formed by covalently connecting a peptide chain linking a nanocarrier end, an arginine-rich penetrating peptide, a matrix metalloproteinase-9 sensitive peptide, and a polyanion inhibitory peptide. The lipid nano drug delivery system can be used for targeting the brain lesion and realizing mitochondrial enrichment by means of modification of the functional penetrating peptide.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: April 28, 2026
    Assignees: SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE, SHANGHAI SECOND MEDICAL INVESTMENT MANAGEMENT CO. LTD
    Inventors: Xiaoling Gao, Qingxiang Song, Gan Jiang, Lepei Chen
  • LIPID NANO DRUG DELIVERY SYSTEM TARGETING BRAIN LESION AND PREPARATION METHOD AND APPLICATION THEREOF
    Publication number: 20220401362
    Abstract: A lipid nano drug delivery system targeting a brain lesion and a preparation method and application thereof. The drug delivery system comprises a lipid, a delivery drug, and a functional penetrating peptide, and the functional penetrating peptide is formed by covalently connecting a peptide chain linking a nanocarrier end, an arginine-rich penetrating peptide, a matrix metalloproteinase-9 sensitive peptide, and a polyanion inhibitory peptide. The lipid nano drug delivery system can be used for targeting the brain lesion and realizing mitochondrial enrichment by means of modification of the functional penetrating peptide.
    Type: Application
    Filed: November 13, 2020
    Publication date: December 22, 2022
    Inventors: Xiaoling GAO, Qingxiang SONG, Gan JIANG, Lepei CHEN