Patents by Inventor Leroy B. Townsend

Leroy B. Townsend has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120270827
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Application
    Filed: June 11, 2012
    Publication date: October 25, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 8202844
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: June 19, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Publication number: 20110178038
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Application
    Filed: March 31, 2011
    Publication date: July 21, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 7928080
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: April 19, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 7625871
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: December 1, 2009
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Publication number: 20090281052
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Application
    Filed: July 9, 2009
    Publication date: November 12, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 7419963
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: September 2, 2008
    Inventors: Leroy B. Townsend, John C. Drach
  • Publication number: 20080146517
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Application
    Filed: February 28, 2008
    Publication date: June 19, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Leroy B. Townsend, John C. Drach
  • Publication number: 20030119762
    Abstract: The present invention relates to polysubstituted benzimidazoles, having the following formula: 1
    Type: Application
    Filed: October 2, 2002
    Publication date: June 26, 2003
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 6455506
    Abstract: The present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds. In one embodiment, the present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds selected from the group consisting of compounds having a formula selected from the following: wherein R2, R4, R5, R6, and R7 are independently the same or different and independently selected from the group consisting of: —H, —F, —Cl, —Br, —I, —NO2, —N(R8)2, —OR8, —SR12, and —CF3, wherein R8 is independently —H or an alkyl group having 1-6 carbon atoms and wherein R12 is independently —H or a hydrocarbyl group having 1-10 carbon atoms; and, R9, R10 and R11 are independently the same or different and are H or a hydroxyl protecting group; anomeric and optical isomers thereof; and, pharmaceutically acceptable salts and prodrug derivatives thereof.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: September 24, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 6455507
    Abstract: Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of preparing these benzimidazole derivatives and pharmaceutical compositions containing them are described.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 24, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: John Charles Drach, Leroy B. Townsend, Frank Leslie Boyd, Jr., Stanley Dawes Chamberlain, Susan Mary Daluge, David Norman Deaton, Marc W. Andersen, George Andrew Freeman
  • Publication number: 20020094963
    Abstract: The present invention relates to certain bezimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.
    Type: Application
    Filed: March 17, 2000
    Publication date: July 18, 2002
    Inventors: JOHN CHARLES DRACH, LEROY B. TOWNSEND, FRANK LESLIE BOYD, STANLEY DAWES CHAMBERLAIN, SUSAN MARY DALUGE, DAVID NORMAN DEATON, MARC W. ANDERSEN, GEORGE ANDREW FREEMAN
  • Patent number: 6413944
    Abstract: Triciribine and analogs are effective antiviral agents.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: July 2, 2002
    Assignees: Regents of the University of Michigan, Wake Forest University
    Inventors: Leroy B. Townsend, John C. Drach, Louis S. Kucera
  • Patent number: 6413938
    Abstract: According to a first aspect of the invention there is provided compounds of formula (I): wherein: R1 is hydroxy; O-acetyl; or a halo atom; R2 is hydroxy; O-acetyl; or a halo atom; R3 is hydrogen; a halo atom; azido; C2-6alkenyl; C2-6alkynyl; C6-14aryl C2-6alkenyl; C6-14arylC2-6alkynyl —NR8R9 (where R8 and R9 may be the same or different and are hydrogen, C1-8alkyl, cyanoC1-8alkyl, hydroxyC1-8alkyl, haloC1-8alkyl, C3-7cycloalkyl, C1-8alkylC3-7cycloalkyl, C2-6alkenyl, C3-7cycloalkylC1-8alkyl, C2-6alkynyl, C6-14aryl, C6-14arylC1-8alkyl, heterocycleC1-8alkyl, C1-8alkylcarbonyl, C6-14arylsulfonyl, C1-8alkysulfonyl, or R8R9 together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); —OR10 (where R10 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl, C2-6alkenyl, C2-6alkynyl, C6-14aryl C2-6alkenyl or C6-14arylC2-6alkynyl); or —SR11 (where R11 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl).
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: July 2, 2002
    Assignees: The Regents of the University of Michigan, Glaxo Wellcome Inc.
    Inventors: Jeffrey H. Tidwell, Stanley D. Chamberlain, George A. Freeman, Joseph H. Chan, George W. Koszalka, Leroy B. Townsend, John C. Drach
  • Patent number: 6342501
    Abstract: This invention relates to a novel class of 4,5,6,7-substituted non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidines which exhibit both significantly lower levels of cytotoxicity and superior antiviral activity than known nucleoside, non-nucleoside, and non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidine derivatives, particularly against human DNA viruses such as cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1).
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: January 29, 2002
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Publication number: 20010011075
    Abstract: The present invention relates to polysubstituted benzimidazoles, having the following formula: 1
    Type: Application
    Filed: February 5, 1999
    Publication date: August 2, 2001
    Inventors: LEROY B TOWNSEND, JOHN C DRACH
  • Patent number: 6214801
    Abstract: This invention pertains to nucleoside analogs that have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to imidazo[1,2-a]pyridine C-nucleosides, as exemplified by compounds such as imidazo[l,2-a]pyridine C5-nucleosides and imidazo[1,2-a]pyridine C3-nucleosides, and may be represented by formula (I), wherein exactly one of Q3 and Q5 is a sugar-like moiety; exactly one of Q3 and Q5 is —H; and Q2, Q6, Q7 and Q8 are independently imidazo[1,2-a]pyridine substituents, such as —H, —F, —Cl, —Br and —I.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: April 10, 2001
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 6093698
    Abstract: This application relates to novel polysubstituted benzimidazoles and compositions and their use in the treatment of viral infections. The polysubstituted benzimidazoles and compositions of the present invention exhibit antiviral properties against viruses of the herpes family, particularly human cytomegalovirus (HCMV) and herpes simplex viruses (HSV).
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: July 25, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 5912356
    Abstract: Antiviral purine nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue. Methods of treating herpes viral infections and pharmaceutical formulations are also described.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: June 15, 1999
    Assignees: Glaxo Wellcome Inc., The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, Susan Mary Daluge
  • Patent number: RE36187
    Abstract: This invention relates to the use of acyclic substituted pyrrolo?2,3-d!pyrimidine nucleoside analogs in the treatment of viral infections. Such substituted compounds retain antiviral properties present in their parent compounds, yet exhibit significantly decreased levels of cytotoxicity, thereby having therapeutic potential as antiviral agents.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: April 6, 1999
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John G. Drach, Charles Shipman, Jr., Jeffrey S. Pudlo