Patents by Inventor Leroy Fong Liu
Leroy Fong Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6995154Abstract: The invention provides compounds of formula I: wherein R1 to R5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, compositions, or salts to treat cancer. In embodiments, R4 and R5 taken together can be a 3, 4, or 5 membered saturated or unsaturated chain comprising members selected from the group consisting of non-peroxide oxygen, sulfur, N(X), and carbon, optionally substituted by oxo; wherein each X is independently absent or is H, O, (C1–C4)alkyl, phenyl or benzyl; and wherein at least one of the chain members is an N—H group.Type: GrantFiled: October 21, 2003Date of Patent: February 7, 2006Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Jung Sun Kim, Leroy Fong Liu
-
Patent number: 6740650Abstract: The invention provides compounds of formula I: wherein R1-R8 and A-G have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.Type: GrantFiled: April 29, 2002Date of Patent: May 25, 2004Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Leroy Fong Liu, Younong Yu
-
Publication number: 20040082637Abstract: The invention provides compounds of formula I: 1Type: ApplicationFiled: October 21, 2003Publication date: April 29, 2004Applicant: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Jung Sun Kim, Leroy Fong Liu
-
Patent number: 6667302Abstract: The invention provides compounds of formula I: wherein R1 to R5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, compositions, or salts to treat cancer. In embodiments, R4 and R5 taken together can be a 3, 4, or 5 membered saturated or unsaturated chain comprising members selected from the group consisting of non-peroxide oxygen, sulfur, N(X), and carbon, optionally substituted by oxo; wherein each X is independently absent or is H, 0, (C1-C4)alkyl, phenyl or benzyl; and wherein at least one of the chain members is an N—H group.Type: GrantFiled: June 13, 2001Date of Patent: December 23, 2003Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. La Voie, Jung Sun Kim, Leroy Fong Liu
-
Publication number: 20030100560Abstract: The invention provides compounds of formula I: 1Type: ApplicationFiled: April 29, 2002Publication date: May 29, 2003Inventors: Edmond J. LaVoie, Leroy Fong Liu, Younong Yu
-
Patent number: 6486167Abstract: The present invention provides compounds of formula I: wherein the R substituents and atoms X and Y are as defined in specification. The present invention also provides pharmaceutical compositions and methods of inhibiting cancer cell growth.Type: GrantFiled: September 29, 2000Date of Patent: November 26, 2002Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. La Voie, Darshan B. Makhey, Baoping Zhao, Leroy Fong Liu
-
Publication number: 20020151575Abstract: The invention provides compounds of formula I: 1Type: ApplicationFiled: June 13, 2001Publication date: October 17, 2002Inventors: Edmond J. LaVoie, Jung Sun Kim, Leroy Fong Liu
-
Patent number: 6399642Abstract: The invention provides a topoisomerase poison of formula I: wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof.Type: GrantFiled: February 28, 2001Date of Patent: June 4, 2002Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Jung Sun Kim, Meera Rangarajan, Leroy Fong Liu
-
Publication number: 20010009919Abstract: The invention provides a topoisomerase poison of formula I: 1Type: ApplicationFiled: February 28, 2001Publication date: July 26, 2001Applicant: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Jung Sun Kim, Meera Rangarajan, Leroy Fong Liu
-
Patent number: 6221892Abstract: The invention provides a topoisomerase poison of formula I: wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof.Type: GrantFiled: January 14, 2000Date of Patent: April 24, 2001Assignee: The State of University of New Jersey, RutgersInventors: Edmond J. LaVoie, Jung Sun Kim, Meera Rangarajan, Leroy Fong Liu
-
Patent number: 6140328Abstract: The invention provides compounds of formula I: whereinR.sub.1 -R.sub.8 and X and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.Type: GrantFiled: December 12, 1997Date of Patent: October 31, 2000Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Darshan B. Makhey, Baoping Zhao, Leroy Fong Liu
-
Patent number: 6121275Abstract: The present invention provides protoberberine alkaloid derivatives useful as anticancer agents, and methods of use thereof. The invention also provides protoberberine derivatives useful as topoisomerase inhibitors. The invention further provides coralyne and nitidine derivatives which are topoisomerase I-targeted therapeutics effective against camptothecin resistant cancer cells, and are especially effective against CNS tumors.Type: GrantFiled: July 31, 1998Date of Patent: September 19, 2000Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Leroy Fong Liu, Darshan B. Makhey
-
Patent number: 6063801Abstract: The invention provides a topoisomerase poison of formula I: ##STR1## wherein R.sub.1 -R.sub.8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof.Type: GrantFiled: February 12, 1998Date of Patent: May 16, 2000Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Jung Sun Kim, Meera Rangarajan, Leroy Fong Liu
-
Patent number: 5981541Abstract: The present invention provides compounds of formula (I): ##STR1## wherein R.sub.1 -R.sub.7, W, X, Y, and Z have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are are useful as anticancer agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.Type: GrantFiled: September 23, 1997Date of Patent: November 9, 1999Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Leroy Fong Liu, Darshan B. Makhey
-
Patent number: 5948797Abstract: The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub. 12)aryl or (6- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with (C.sub.1 -C.sub.4)alkyl; X is H, CN, CHO, OH, acetyl, CF.sub.3, OCH.sub.3, NO.sub.2 or NH.sub.2 ; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; or a pharmaceutically acceptable salt therein.Type: GrantFiled: January 13, 1997Date of Patent: September 7, 1999Assignee: Rutgers, The State University Of New JerseyInventors: Edmond Joseph LaVoie, Leroy Fong Liu, Qun Sun
-
Patent number: 5807874Abstract: The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub.12)aryl or (6- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with (C.sub.1 -C.sub.4)alkyl; X is H, CN, CHO, OH, acetyl, CF.sub.3, OCH.sub.3, NO.sub.2 or NH.sub.2 ; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; or a pharmaceutically acceptable salt therein.Type: GrantFiled: May 17, 1995Date of Patent: September 15, 1998Assignee: Rutgers, The State University of New JerseyInventors: Edmond Joseph LaVoie, Leroy Fong Liu, Qun Sun
-
Patent number: 5770617Abstract: The present invention provides a method of treatment of fungal infection with an antifungal topoisomerase I inhibitor of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub.12)aryl, a (5- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with H, (C.sub.1 -C.sub.4)alkyl or benzyl; or benzo; X is H, CN, CHO, OH, acetyl, CF.sub.3, O(C.sub.1 -C.sub.4)alkyl, NO.sub.2, NH.sub.2, halogen or halo-(C.sub.1 -C.sub.4)alkyl; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; and each Z is individually H, (C.sub.1 -C.sub.4)alkyl, halogen or halo(C.sub.1 -C.sub.4)alkyl; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 21, 1997Date of Patent: June 23, 1998Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Leroy Fong Liu, Qun Sun
-
Patent number: 5767142Abstract: The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub.12)aryl or (5- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with (C.sub.1 -C.sub.4)alkyl; X is H, CN, CHO, OH, acetyl, CF.sub.3, O(C.sub.1 -C.sub.4)alkyl, NO.sub.2, NH.sub.2, halogen or halo-(C.sub.1 -C.sub.4)alkyl; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; and each Z is individually H, (C.sub.1 -C.sub.4)alkyl, halogen or halo(C.sub.1 -C.sub.4)alkyl; or a pharmaceutically acceptable salt therein.Type: GrantFiled: March 20, 1996Date of Patent: June 16, 1998Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Leroy Fong Liu, Qun Sun