Patents by Inventor LESLEY LYNN YOUNG

LESLEY LYNN YOUNG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GITRL FUSION PROTEINS AND USES THEREOF
    Publication number: 20200140510
    Abstract: The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.
    Type: Application
    Filed: September 3, 2019
    Publication date: May 7, 2020
    Inventors: Ross Anthony Stewart, Natalie Jo Tigue, Lesley Lynn Young, Daniel Ramsay Higazi, Lisa Bamber, Sudharsan Sridharan, Rebecca Leyland, Nicholas Mason Durham
  • GITRL fusion proteins comprising a human coronin 1a derived trimerization domain
    Patent number: 10428131
    Abstract: The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: October 1, 2019
    Assignee: MEDIMMUNE LIMITED
    Inventors: Ross Anthony Stewart, Natalie Jo Tigue, Lesley Lynn Young, Daniel Ramsay Higazi, Lisa Bamber, Sudharsan Sridharan, Rebecca Leyland, Nicholas Mason Durham
  • GITRL FUSION PROTEINS AND USES THEREOF
    Publication number: 20170073386
    Abstract: The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.
    Type: Application
    Filed: August 11, 2016
    Publication date: March 16, 2017
    Inventors: Ross Anthony Stewart, Natalie Jo Tigue, Lesley Lynn Young, Daniel Ramsay Higazi, Lisa Bamber, Sudharsan SRIDHARAN, Rebecca Leyland, Nicholas Mason Durham
  • A COMPOSITION COMPRISING A NOTCH LIGAND AND AN ALLERGENB OR ALLERGEN BYSTANDER ANTIGEN
    Publication number: 20100303867
    Abstract: A method is provided for reducing an immune response to an allergen or antigenic determinant thereof in a mammal by administering a modulator of the Notch signalling pathway.
    Type: Application
    Filed: April 23, 2010
    Publication date: December 2, 2010
    Inventors: MARK WILLIAM BODMER, EMMANUEL CYRILLE PASCAL BRIEND, BRIAN ROBERT CHAMPION, ANDREW CHRISTOPHER LENNARD, GRAHAME JAMES MCKENZIE, SILVIA RAGNO, TAMARA TUGAL, GEORGE ALBERT WARD, LESLEY LYNN YOUNG