Patents by Inventor Lesley Murray

Lesley Murray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for use of MPL ligands with primitive human stem cells
    Publication number: 20060024275
    Abstract: Myeloproliferative leukemia receptor (mpl) ligands, such as thrombopoietin, act on a primitive subpopulation of human stem cells having the characteristics of self-renewal and ability to give rise to all hematopoietic cell lineages. Thrombopoietin supports both megakaryocytic differentiation and primitive progenitor cell expansion of CD34+ and CD34+ sub-populations (CD34+Lin?, CD34+Thy-1+Lin?, and CD34+Lin? Rh123?lo). Thrombopoietin also stimulated quiescent human stem cells to begin cycling. Thus, mpl ligands are useful for expanding primitive stem cells for restoration of hematopoietic capabilities and for providing modified human stem cells for gene therapy applications.
    Type: Application
    Filed: July 1, 2005
    Publication date: February 2, 2006
    Inventors: Lesley Murray, Judy Young
  • Treatment of excessive osteolysis with indolinone compounds
    Publication number: 20040209937
    Abstract: Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.
    Type: Application
    Filed: February 19, 2004
    Publication date: October 21, 2004
    Applicant: SUGEN, INC.
    Inventors: Lesley Murray, Anne-Marie O'Farrell, Tinya Abrams
  • Combination administration of an indolinone with a chemotherapeutic agent for cell proliferation disorders
    Publication number: 20040152759
    Abstract: The invention relates to a method of treating cancer by administering a combination of an indolinone compound with another chemotherapeutic agent.
    Type: Application
    Filed: November 14, 2003
    Publication date: August 5, 2004
    Applicant: SUGEN, Inc.
    Inventors: Tinya Abrams, Lesley Murray, Nancy Pryer, Julie Cherrington
  • Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof
    Patent number: 5665557
    Abstract: The invention relates to methods of obtaining compositions enriched in hematopoietic stem cells by separating out an enriched fraction of cells expressing the marker CDw109. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells obtained therefrom are also provided by the invention. Methods of use of the cells are also included.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: September 9, 1997
    Assignees: Systemix, Inc., The Toronto Hospital Research Institute
    Inventors: Lesley Murray, D. Robert Sutherland
  • Cord organizer
    Patent number: D966079
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: October 11, 2022
    Inventor: Lesley Murray