Patents by Inventor Lesley Probert

Lesley Probert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING NEUROLOGICAL DISEASES
    Publication number: 20230129938
    Abstract: The present disclosure is directed to a method of treating neurological disorder comprising peripheral administration to a patient in need thereof a DN-TNF polypeptide that inhibits the activity of soluble TNF- but not transmembrane TNF-?.
    Type: Application
    Filed: June 20, 2022
    Publication date: April 27, 2023
    Applicant: XENCOR, INC.
    Inventors: David Szymkowski, Malu Tansey, Lesley Probert
  • Methods of treating neurological diseases
    Patent number: 11365229
    Abstract: The present disclosure is directed to a method of treating neurological disorder comprising peripheral administration to a patient in need thereof a DN-TNF polypeptide that inhibits the activity of soluble TNF- but not transmembrane TNF-?.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: June 21, 2022
    Assignee: XENCOR, INC.
    Inventors: David Szymkowski, Malu Tansey, Lesley Probert
  • METHODS OF TREATING NEUROLOGICAL DISEASES
    Publication number: 20200172590
    Abstract: The present disclosure is directed to a method of treating neurological disorder comprising measuring c-reactive protein in a patient and peripherally administering to the patient a DN-TNF polypeptide that inhibits the activity of soluble TNF-but not transmembrane TNF-?.
    Type: Application
    Filed: April 1, 2019
    Publication date: June 4, 2020
    Applicant: XENCOR, INC.
    Inventors: David Szymkowski, Malu Tansey, Lesley Probert
  • CONJUGATES COMPRISING MANNAN AND MYELIN BASIC PROTEIN (MBP)
    Publication number: 20160095935
    Abstract: A first aspect of the invention relates to a conjugate including mannan and at least one epitope comprising a peptide fragment of a protein selected from myelin basic protein (MBP), myelin oligodentrocyte glycoprotein (MOG) and proteolipid protein (PLP), said peptide fragment being in linear or cyclic form; and wherein said epitope is linked to mannan via a [(Lys-Gly)n] bridge, where n is an integer from 1 to 10. Further aspects of the invention relate to pharmaceutical compositions comprising said conjugates, and their use in the preparation of a medicament for treating an immune disorder.
    Type: Application
    Filed: October 7, 2015
    Publication date: April 7, 2016
    Applicant: VIANEX S.A
    Inventors: John Matsoukas, Theodoros Tselios, Vasso Apostolopoulos, Vivian Tseveleki, Maria Katsara, Lesley Probert
  • Conjugates comprising mannan and myelin oligodentrocyte glycoprotein (MOG)
    Patent number: 9180174
    Abstract: A first aspect of the invention relates to a conjugate including mannan and at least one epitope comprising a peptide fragment of a protein selected from myelin basic protein (MBP), myelin oligodentrocyte glycoprotein (MOG) and proteolipid protein (PLP), said peptide fragment being in linear or cyclic form; and wherein said epitope is linked to mannan via a [(Lys-Gly)n] bridge, where n is an integer from 1 to 10. Further aspects of the invention relate to pharmaceutical compositions comprising said conjugates, and their use in the preparation of a medicament for treating an immune disorder.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: November 10, 2015
    Assignee: VIANEX S.A.
    Inventors: John Matsoukas, Theodoros Tselios, Vasso Apostolopoulos, Vivian Tseveleki, Maria Katsara, Lesley Probert
  • Methods of Treating Neurological Diseases
    Publication number: 20150239951
    Abstract: The present disclosure is directed to a method of treating neurological disorder comprising peripheral administration to a patient in need thereof a DN-TNF polypeptide that inhibits the activity of soluble TNF- but not transmembrane TNF-?.
    Type: Application
    Filed: September 10, 2013
    Publication date: August 27, 2015
    Inventors: David Szymkowski, Malu Tansey, Lesley Probert
  • THERAPEUTIC MYELIN SHEATH DERIVED ANTAGONIST PEPTIDE CONJUGATES
    Publication number: 20110243981
    Abstract: A first aspect of the invention relates to a conjugate comprising: (i) mannan; and (ii) at least one epitope comprising a peptide fragment of a protein selected from myelin basic protein (MBP), myelin oligodentrocyte glycoprotein (MOG) and proteolipid protein (PLP), said peptide fragment being in linear or cyclic form; wherein said epitope is linked to mannan via a [(LyS-GIy)n] bridge, where n is an integer from 1 to 10. Further aspects of the invention relate to pharmaceutical compositions comprising said conjugates, and their use in the preparation of a medicament for treating an immune disorder.
    Type: Application
    Filed: January 22, 2009
    Publication date: October 6, 2011
    Applicant: Eldrug S.A.
    Inventors: John Matsoukas, Theodoros Tselios, Vasso Apostolopoulos, Vivian Tseveleki, Maria Katsara, Lesley Probert