Patents by Inventor Leslie A. Farkas

Leslie A. Farkas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9655539
    Abstract: A system and method is described for a catheter guidance system which allows an operator to use a mapping catheter to specify tissue target locations for the automatic guidance of a second therapeutic catheter. The operator places a mapping catheter at a desired location, and commands the catheter guidance system by either selecting a point on that catheter or one of the catheter electrode electrocardiograms. The operator may target the selected dynamic location, or tissue contact beyond that location on a specific side of the mapping catheter.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: May 23, 2017
    Assignee: Magnetecs, Inc.
    Inventors: Yehoshua Shachar, Bruce Marx, David Johnson, Leslie Farkas, Steven Kim
  • Patent number: 9329173
    Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: May 3, 2016
    Assignee: Sensor-Kinesis Corporation
    Inventors: Yehoshua Shachar, Winston Wu, Thomas Chen, Leslie Farkas, Brett Jordan, Paladin Luboff, Herwin Chan, Kyle Zimmerman
  • Patent number: 9310363
    Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: April 12, 2016
    Assignee: Sensor-Kinesis Corporation
    Inventors: Yehoshua Shachar, Winston Wu, Thomas Chen, Leslie Farkas, Brett Jordan, Paladin Luboff, Herwin Chan, Kyle Zimmerman
  • Patent number: 8986214
    Abstract: The invention relates to a method for using tissue contact technology to optimize automated cardiac chamber mapping algorithms to both speed up the mapping process and guarantee the definition of the actual chamber limits. The invention further comprises a method for conveying tissue type information to such automatic mapping algorithms so as to allow them to adapt their point collection density within areas of particular interest. The method is enhanced by the use of a magnetic chamber that employs electromagnetic coils configured as a waveguide that radiate magnetic fields by shaping the necessary flux density axis on and around the catheter distal tip so as to push, pull and rotate the tip on demand and as defined by such automatic mapping algorithms.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: March 24, 2015
    Assignee: Magnetecs Inc.
    Inventors: Yehoshua Shachar, Bruce Marx, Leslie Farkas, Eli Gang, Laszlo Farkas
  • Patent number: 8827986
    Abstract: A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: September 9, 2014
    Assignee: Pharmaco-Kinesis Corporation
    Inventors: Yehoshua Shachar, Thomas C. Chen, Leslie Farkas, Brett Jordan, Kyle Zimmerman, Herwin Chan, Winston Wu
  • Patent number: 8457714
    Abstract: A tissue-contact seeking method and apparatus is described that enhances catheter position detection and control systems in making and maintaining continuous tissue contact in a highly dynamic frame, such as under the rigors of cardiac motion. Tissue-seeking logical routines use a tissue contact sensing system to advance a catheter to relatively continuous tissue contact, or detect obstacles, in cooperation with the catheter position detection and control systems. Additional logical routines are capable of optimizing the contact direction of the catheter tip by controlling the rotation angle and chamber position of the introducer.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: June 4, 2013
    Assignee: Magnetecs, Inc.
    Inventors: Yehoshua Shachar, Bruce Marx, Leslie Farkas, Laszlo Farkas, David Johnson, Eli Gang
  • Publication number: 20130006100
    Abstract: A method and apparatus for detecting position and orientation of catheter distal magnetic element end while moving in a patient's heart is described. The apparatus comprising of four sensors, detecting the magnetic field of a generated by the catheter tip. Each sensor transmits the field magnitude and direction to a detection unit, which filters the signals and removes other field sources, such, as generated by CGCI coils and external medical hardware. The method allows the measurements of magnitude corresponding to the catheter tip distance from the sensor and the orientation of the field showing the magnetic tip orientation. Since the tip's magnetic field is not symmetric, the position and orientation computation technique are not independent of each other. Hence, an iterative calculation is used to converge to a solution.
    Type: Application
    Filed: April 5, 2012
    Publication date: January 3, 2013
    Applicant: MAGNETECS, INC.
    Inventors: Yehoshua Shachar, Bruce Marx, Leslie Farkas
  • Publication number: 20120316431
    Abstract: The invention is a method of rotating a catheter while it is manually guided in order to increase the volume of space it passes through during a geometric mapping procedure as to provide a higher and more uniform location data point cloud density in a volumetric mapping system.
    Type: Application
    Filed: May 11, 2012
    Publication date: December 13, 2012
    Applicant: MAGNETECS, INC.
    Inventors: Yehoshua Shachar, Bruce Marx, David Johnson, Leslie Farkas, Steven Kim
  • Publication number: 20120310111
    Abstract: Using the linear forces that are provided by an electromagnetic solenoid applied near the distal end of a medical catheter, various surgical instruments can be actuated or deployed for use in interventional medicine. The linear actuator uses the principles of magnetic repulsion and attraction as a means for moving a bobbin that can be attached to various types of moving components that translate linear movements into the actuation of a tool that is attached to the linear actuator. Using independent solenoid coils, movement modality is increased from two possible positions to three.
    Type: Application
    Filed: May 4, 2012
    Publication date: December 6, 2012
    Applicant: Magnetecs, Inc.
    Inventors: Yehoshua Shachar, Leslie Farkas
  • Publication number: 20120310066
    Abstract: A system method that tracks one or more points on the surface of a cardiac tissue throughout a cardiac cycle and collect various types of data points which are then subsequently used to generate a corresponding model of the tissue and display the model as a 3D color coded image is described. In one embodiment, the system determines the position and orientation of a distal tip of a catheter, manipulates the catheter tip so as to maintain constant contact between the tip and a region of cardiac tissue using the impedance method, acquires positional and electrical data of the tip-tissue configuration through an entire heartbeat cycle, repeats the measurements as many times as needed in different tissue regions, and forms a 3D color coded map displaying various mechanical and electrical properties of the heart using the acquired data.
    Type: Application
    Filed: June 7, 2012
    Publication date: December 6, 2012
    Applicant: MAGNETECS, INC.
    Inventors: Yehoshua Shachar, Bruce Marx, Laszlo Farkas, David Johnson, Leslie Farkas
  • Patent number: 8323269
    Abstract: A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled lumen, intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: December 4, 2012
    Assignee: Pharmaco-Kinesis Corporation
    Inventors: Yehoshua Shachar, Thomas C. Chen, Leslie Farkas, Bruce Marx, David Johnson, Laszlo Farkas
  • Patent number: 8323270
    Abstract: A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents mixed with Avastin at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, the medicating agent Avastin is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. In cases where a tumor resection is not performed, an intratumoral catheter will be implanted. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: December 4, 2012
    Assignee: Pharmaco-Kinesis Corporation
    Inventors: Yehoshua Shachar, Thomas C. Chen, Leslie Farkas, Bruce Marx, David Johnson, Laszlo Farkas
  • Publication number: 20120296200
    Abstract: A system and method is described for a catheter guidance system which allows an operator to use a mapping catheter to specify tissue target locations for the automatic guidance of a second therapeutic catheter. The operator places a mapping catheter at a desired location, and commands the catheter guidance system by either selecting a point on that catheter or one of the catheter electrode electrocardiograms. The operator may target the selected dynamic location, or tissue contact beyond that location on a specific side of the mapping catheter.
    Type: Application
    Filed: April 19, 2012
    Publication date: November 22, 2012
    Applicant: MAGNETECS, INC.
    Inventors: Yehoshua Shachar, Bruce Marx, David Johnson, Leslie Farkas, Steven Kim
  • Publication number: 20120288838
    Abstract: A system is disclosed for incorporating a realistic simulated catheter or catheters within a catheter guidance and control system that operate from the same closed-loop position control feedback and geometric mapping data as the real position control system and are able to make contact with real and simulated datasets. These catheters may be operated in a pure simulation mode without interacting with real catheters and position control hardware, or may be used as control cursors to enhance the placement of catheter positioning targets. The catheter tip, which is focus of magnetic control, is realistically guided by the control system parameters, while the remainder of the catheter line is realistically constrained by the mapped chamber geometry and introducer sheath.
    Type: Application
    Filed: April 18, 2012
    Publication date: November 15, 2012
    Applicant: MAGNETECS, INC.
    Inventors: Yehoshua Shachar, Bruce Marx, David Johnson, Leslie Farkas, Steven Kim
  • Publication number: 20120289780
    Abstract: A magnetically guided device driven by the repulsive forces generated by superconductive materials, housed in a thermally insulated vessel, due to phenomenon known as the Meissner-effect in response to the externally generated magnetic fields. The vessels will be installed in or on medical diagnostic, delivery or other procedural devices or capsules, and will enable wireless maneuvering and navigation of the host device through the lumens and cavities of the human body without any physical contact. Medical application fields include, but are not limited to, visual mapping, diagnostics, biopsy and other therapeutic and drug delivery procedures in the human body. The vessel is equipped with superconductive material, such as superconductive rings and/or disks, possessing supermagnetic properties.
    Type: Application
    Filed: November 17, 2010
    Publication date: November 15, 2012
    Inventors: Laszlo Farkas, Leslie Farkas
  • Publication number: 20120289822
    Abstract: The Lorentz-Active Sheath (LAS) serves as a conduit for other medical devices such as catheters, balloons, biopsy needles, etc. The sheath is inserted through a vein or other body orifice and is guided into the area of the patient where the operation is to be performed. The position and orientation of the LAS is tracked via an industry standard position detection system which senses electrical signals that are emitted from several electrodes coupled to the LAS. The signals received from the LAS are used to calculate an accurate and reliable assessment of the actual position of the LAS within the patient. The electrode signals also serve to create a reference frame which is then used to act as a motion compensation filter and fiducial alignment system for the movement of the LAS-hosted medical tool.
    Type: Application
    Filed: April 18, 2012
    Publication date: November 15, 2012
    Applicant: MAGNETECS, INC.
    Inventors: Yehoshua Shachar, Bruce Marx, Leslie Farkas, David Johnson, Laszlo Farkas
  • Publication number: 20120149981
    Abstract: An in-vivo device includes a magnetic steering unit (MSU) to maneuver it by an external electromagnetic field. The MSU may include a permanent magnets assembly to produce a magnetic force for navigating the device. The MSU may include a magnets carrying assembly (MCA) to accommodate the permanent magnet(s). The MCA may be designed to generate eddy currents, in response to AC magnetic field, to apply a repelling force. The in-vivo device may also include a multilayered imaging and sensing printed circuit board (MISP) to capture and transmit images. The MISP may include a sensing coil assembly (SCA) to sense electromagnetic fields to determine a location/orientation/angular position of the in-vivo device. Data representing location/orientation/angular position of the device may be used by a maneuvering system to generate a steering magnetic field to steer the in-vivo device from one location or state to another location or state.
    Type: Application
    Filed: December 8, 2011
    Publication date: June 14, 2012
    Inventors: Semion KHAIT, Zvika Gilad, Josh Schachar, Laszlo Farkas, Bruce Marx, David Johnson, Shawn Hakim, Leslie Farkas
  • Patent number: 8145434
    Abstract: A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: March 27, 2012
    Assignee: Pharmaco-Kinesis Corporation
    Inventors: Josh Yehoshua Shachar, Winston H. Wu, Leslie Farkas, Thomas Chen
  • Patent number: 8133172
    Abstract: Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: March 13, 2012
    Assignee: Pharmaco-Kinesis Corporation
    Inventors: Josh Shachar, Thomas Chen, Leslie Farkas, Winston Wu, Kyle Zimmerman, Moran Cerf, Bruce Marx, David Johnson, Laszlo Farkas
  • Publication number: 20120041562
    Abstract: A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: PHARMACO-KINESIS CORPORATION
    Inventors: Yehoshua Shachar, Thomas C. Chen, Leslie Farkas, Brett Jordan, Kyle Zimmerman, Herwin Chan, Winston Wu