Patents by Inventor Leslie A. Geddes
Leslie A. Geddes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7569018Abstract: An auditory pulse monitor for noninvasively detecting the amplitude of arterial pulses on a beat-by-beat basis. A light-weight optical sensor including a light source and photodetector is adapted for application to the skin surface of a subject over a tissue bed containing an arterial supply. The photodetector generates an output signal proportional to the amplitude of an arterial pulse, and an electronic circuit connected to the photodetector generates a signal having a frequency proportional to the photodetector output signal level. A speaker or other audio indicator connected to the electronic circuit generates an audible tone indicating the amplitude of the arterial pulse. Another aspect of the invention is an improvement in automated or automatic external defibrillators (AEDs). An AED is disclosed which optically detects arterial pulses after delivering a defibrillation shock and signals the need for CPR if it detects inadequate cardiac pumping following successful defibrillation.Type: GrantFiled: February 18, 2003Date of Patent: August 4, 2009Assignee: Purdue Research FoundationInventors: Leslie A. Geddes, Kirk S. Foster, Rebecca A. Roeder
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Patent number: 7164938Abstract: An optical noninvasive vital sign monitor comprising a reflectance-type optical sensor within a pressurizable capsule retained by a headband, the capsule having an optically transparent or translucent inner wall adapted for placement against a subject's forehead. The optical sensor is mounted on the inside surface of the pressurizable capsule's inner wall, which contacts the subject's forehead during use, and includes a light source and a photodetector aimed toward the inside surface of the inner capsule wall. One embodiment of the vital sign monitor includes optical oscillometric circuit means responsive to an output signal from the optical sensor for determining systolic pressure, mean pressure and diastolic pressure during a transition in capsule pressure between a pressure greater than normal systolic pressure and a pressure less than normal diastolic pressure.Type: GrantFiled: June 20, 2005Date of Patent: January 16, 2007Assignee: Purdue Research FoundationInventors: Leslie A. Geddes, Rebecca A. Roeder, Kirk S. Foster, George P. Graber
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Patent number: 7096059Abstract: An electrocardiography device and method that is able to obtain the electrocardiogram of a freely moving animal. The device and method utilizes at least two catheters to obtain the electrical signals from the heart of the animal being tested. The catheters are filled with an electrically-conductive, physiological solution and are used in combination with at least two test leads that are able to transfer the electrical signals from the animal to an ECG monitoring device. The device and method also allows for fluids to flow through the catheters to other devices such as a blood sampler controller and/or an infusion pump.Type: GrantFiled: July 2, 2003Date of Patent: August 22, 2006Assignee: Bioanalytical Systems, Inc.Inventors: Leslie A. Geddes, Candice B. Kissinger, Joseph A. Bougher, Stephen J. Clevenger
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Patent number: 7014611Abstract: An oscillometric, noninvasive blood pressure monitor comprising an inflatable cuff adapted for placement around a body member, a pump for cuff inflation, a pressure transducer connected to the cuff, means for detecting oscillations in arterial pressure occurring during a transition in cuff pressure between a pressure greater than normal systolic pressure and a pressure less than normal diastolic pressure, and a blood pressure measurement circuit which is capable of determining the maximum amplitude (Am) of the oscillations, identifying mean cuff pressure (Pm) as the coincident value of the cuff-pressure signal from the pressure transducer, and determining systolic pressure as a function of both Am and Pm. In accordance with one aspect of the invention, the blood pressure monitor has an optical sensor including a light source and photodetector optically coupled to the body member proximate to the cuff.Type: GrantFiled: June 24, 2004Date of Patent: March 21, 2006Assignee: Purdue Research FoundationInventors: Leslie A. Geddes, Rebecca A. Roeder
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Publication number: 20050283082Abstract: An optical noninvasive vital sign monitor comprising a reflectance-type optical sensor within a pressurizable capsule retained by a headband, the capsule having an optically transparent or translucent inner wall adapted for placement against a subject's forehead. The optical sensor is mounted on the inside surface of the pressurizable capsule's inner wall, which contacts the subject's forehead during use, and includes a light source and a photodetector aimed toward the inside surface of the inner capsule wall. One embodiment of the vital sign monitor includes optical oscillometric circuit means responsive to an output signal from the optical sensor for determining systolic pressure, mean pressure and diastolic pressure during a transition in capsule pressure between a pressure greater than normal systolic pressure and a pressure less than normal diastolic pressure.Type: ApplicationFiled: June 20, 2005Publication date: December 22, 2005Inventors: Leslie Geddes, Rebecca Roeder, Kirk Foster, George Graber
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Patent number: 6801798Abstract: A member-illuminating cuff for measurement of systolic, mean and diastolic pressure, oxygen saturation, pulse and respiratory rate in small body members, comprising a hinged cuff housing, one or more light sources mounted on a first section of the housing, a photodetector mounted on a second section of the housing, and a disposable, inflatable cuff adapted to fit within the cuff housing and around a body member placed therein.Type: GrantFiled: June 20, 2002Date of Patent: October 5, 2004Assignee: Purdue Research FoundationInventors: Leslie A. Geddes, Kirk S. Foster, William E. Schoenlein, Rebecca A. Roeder, Claude B. Harrington
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Publication number: 20040006280Abstract: The present invention provides an electrocardiography device that is able to obtain the electrocardiogram of a freely moving animal. The present invention utilizes at least two catheters to obtain the electrical signals from the heart of the animal being tested. The catheters are filled with an electrically-conductive, physiological solution and are used in combination with at least two test leads that are able to transfer the electrical signals from the animal to an ECG monitoring device. The present invention also allows for fluids to flow through the catheters to other devices such as a blood sampler controller and/or an infusion pump.Type: ApplicationFiled: July 2, 2003Publication date: January 8, 2004Applicant: Bioanalytical Systems, Inc., an Indiana corporationInventors: Leslie A. Geddes, Candice B. Kissinger, Joseph A. Bougher, Stephen J. Clevenger
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Patent number: 6546287Abstract: A controlled-power defibrillator and method of defibrillation for automatically compensating for changes in patient resistance during delivery of a defibrillation pulse. A switching power converter is connected between a storage capacitor and a pair of electrodes adapted for connection to a patient's body, either internally or externally. A closed-loop power control circuit is operatively connected to the power converter for control of the power delivered to the patient, the power control circuit generating a target voltage signal for the storage capacitor, the target voltage signal having a defined relationship with the waveform of the power desired to be delivered to the patient. The power control circuit monitors the actual voltage on the storage capacitor and adjusts the delivery of power to the patient as a function of the difference between desired and actual storage capacitor voltage.Type: GrantFiled: October 6, 2000Date of Patent: April 8, 2003Assignee: Purdue Research FoundationInventors: William J. Havel, Joe D. Bourland, Leslie A. Geddes, Willis A. Tacker, Darrell O. Wagner
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Publication number: 20030065379Abstract: A tissue graft construct and method for repairing the inner linings of damaged or diseased vertebrate vessels is described. The method comprises the steps of positioning a tissue graft construct within a blood vessel at a site in need of repair. The tissue graft construct comprises a stent (3) covered with submucosal tissue (4) wherein the stent (3) is formed for receiving the distal end of a catheter (1) having an inflatable balloon (2).Type: ApplicationFiled: November 4, 2002Publication date: April 3, 2003Inventors: Charles F. Babbs, Neal F. Fearnot, Stephen F. Badylak, Leslie A. Geddes, Michael C. Hiles, Joe D. Bourland
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Publication number: 20030036690Abstract: A member-illuminating cuff for measurement of systolic, mean and diastolic pressure, oxygen saturation, pulse and respiratory rate in small body members, comprising a hinged cuff housing, one or more light sources mounted on a first section of the housing, a photodetector mounted on a second section of the housing, and a disposable, inflatable cuff adapted to fit within the cuff housing and around a body member placed therein.Type: ApplicationFiled: June 20, 2002Publication date: February 20, 2003Inventors: Leslie A. Geddes, Kirk S. Foster, William E. Schoenlein, Rebecca A. Roeder, Claude B. Harrington
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Patent number: 6475232Abstract: A tissue graft construct and method for repairing the inner linings of damaged or diseased vertebrate vessels is described. The method comprises the steps of positioning a tissue graft construct within a blood vessel at a site in need of repair. The tissue graft construct comprises a stent (3) covered with submucosal tissue (4) wherein the stent (3) is formed for receiving the distal end of a catheter (1) having an inflatable balloon (2).Type: GrantFiled: June 10, 1999Date of Patent: November 5, 2002Assignee: Purdue Research FoundationInventors: Charles F. Babbs, Neal F. Fearnot, Stephen F. Badylak, Leslie A Geddes, Michael C. Hiles, Joe D. Bourland
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Patent number: 6187039Abstract: An easy-to-produce and mechanically strong tube of an implantable submucosal tissue has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the submucosal tissue prosthesis generally involves wrapping a first sheet of submucosal tissue (60) and a second sheet of submucosal tissue (70) around a mandrel (50), wherein the first end (74) and the second opposite end (76) of the second sheet of submucosal tissue (70) are sutured together with sutures (78). The submucosal tissue is compressed and dried on the mandrel (50) before removing the construct by pulling on a first end (54) and a second end (56) of a water permeable tape to unwind the tape and thus release the construct for eventual use.Type: GrantFiled: May 4, 1999Date of Patent: February 13, 2001Assignee: Purdue Research FoundationInventors: Michael C. Hiles, Umesh H. Patel, Leslie A. Geddes, Stephen F. Badylak
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Patent number: 6126686Abstract: A method for preparing vascular valves from submucosal tissue is described. Both bicuspid and tricuspid valve constructs are described. The bicuspid constructs can be formed with or without a supporting stent. The tricuspid constructs are formed by fixing submucosal tissue to a supporting stent, folding the submucosal tissue, and forming the valve commissures from the folded submucosal tissue by cutting along the folds. The artificial vascular valves are useful for replacing damaged or diseased valves of a warm-blooded vertebrate.Type: GrantFiled: June 10, 1999Date of Patent: October 3, 2000Assignee: Purdue Research FoundationInventors: Stephen F. Badylak, Arthur C. Coffey, Leslie A. Geddes, Michael C. Hiles, James Hong, Rebecca Roeder
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Patent number: 6096347Abstract: The use of submucosal tissue of a warm blooded vertebrate to manufacture a tissue graft composition that induces the formation of endogenous cardiac tissues in vivo upon contact of the cardiac tissues with the manufactured composition.Type: GrantFiled: May 4, 1999Date of Patent: August 1, 2000Assignee: Purdue Research FoundationInventors: Leslie A. Geddes, Stephen F. Badylak, Robert G. Matheny, William E. Schoenlein, Fred J. Obermiller, William J. Havel
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Patent number: 5916239Abstract: A closed-loop, variable-frequency, vagal-stimulation apparatus for control of ventricular rate during atrial fibrillation. In one embodiment the apparatus includes a stimulator applied to the left vagus nerve and a controller programmed to automatically and continuously adjust the vagal stimulation frequency as a function of the difference between actual and desired ventricular excitation rates. In a second embodiment the apparatus includes a vagal nerve stimulator and a controller which automatically adjusts the vagal stimulation frequency as a function of the difference between ventricular excitation rate and arterial pulse rate in order to eliminate or minimize pulse deficit.Type: GrantFiled: November 24, 1997Date of Patent: June 29, 1999Assignee: Purdue Research FoundationInventors: Leslie A. Geddes, Tarek Elabbady, William E. Schoenlein, Matthew Waninger, Joe D. Bourland
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Patent number: 5690681Abstract: A closed-loop variable frequency vagal stimulation apparatus for control of ventricular rate during atrial fibrillation. In one embodiment the apparatus includes a stimulator applied to the left vagus nerve and a proportional controller programmed to automatically and continuously adjust the vagal stimulation frequency proportionally as a function of the difference between actual and desired ventricular excitation rates. In a second embodiment the apparatus includes a vagal nerve stimulator and a controller which automatically adjusts the vagal stimulation frequency as a function of the difference between ventricular excitation rate and arterial pulse rate in order to eliminate or minimize pulse deficit.Type: GrantFiled: March 29, 1996Date of Patent: November 25, 1997Assignee: Purdue Research FoundationInventors: Leslie A. Geddes, Tarek Elabbady, William E. Schoenlein, Matthew Waninger, Joe D. Bourland
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Patent number: 5573784Abstract: Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.Type: GrantFiled: April 18, 1995Date of Patent: November 12, 1996Assignees: Purdue Research Foundation, Methodist Hospital of Indiana, Inc.Inventors: Stephen F. Badylak, Leslie A. Geddes, K. Donald Shelbourne, Gary C. Lantz, Arthur C. Coffey
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Patent number: 5445833Abstract: Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.Type: GrantFiled: December 15, 1993Date of Patent: August 29, 1995Assignees: Purdue Research Foundation, Methodist Hospital of Indiana, Inc.Inventors: Stephen F. Badylak, Leslie A. Geddes, K. Donald Shelbourne, Gary C. Lantz, Arthur C. Coffey
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Patent number: 5372821Abstract: Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.Type: GrantFiled: December 15, 1993Date of Patent: December 13, 1994Assignee: Purdue Research FoundationInventors: Stephen F. Badylak, Leslie A. Geddes, K. Donald Shelbourne, Gary C. Lantz, Arthur C. Coffey
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Patent number: 5354274Abstract: A device is provided for facilitating oral administration of unit dosages of liquid formulations, particularly to pediatric and geriatric patients. Sealed cartridges containing unit doses of liquid nutrients or medications can be locked into the device and at the same time, breached so that the contained-liquid formulation can flow from the cartridge into a hollow nipple for facile oral consumption. The liquid formulation-contained sealed cartridge includes a container having a side wall collapsible responsive to withdrawal of liquid from the hollow nipple.Type: GrantFiled: August 20, 1992Date of Patent: October 11, 1994Assignees: Methodist Hospital of Indiana, Inc., Purdue Research FoundationInventors: Robert J. Demeter, Stephen F. Badylak, Kirk S. Foster, Leslie A. Geddes