Patents by Inventor Leslie A. Hokama

Leslie A. Hokama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6482799
    Abstract: This invention provides a novel anti-microbial system suitable for formulation in a wide variety of ophthalmic solutions. In particular the composition comprises an antimicrobial peptide that is an indolicidin and a buffer compatible with application to a mammalian eye, wherein the buffer is a Good's buffer or the buffer has a halide ion concentration less than 0.85 wt %. The compositions are useful for storing, cleaning, or disinfecting a contact lens. In particular the compositions are self-preserving upon lengthy storage, effective in cleaning and sterilizing contact lenses upon exposure of the lens to the composition, do not require the need for physical or thermal treatment of the lens and enable the immediate application of the lens to the eye without the need for neutralization, deactivation or washing.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: November 19, 2002
    Assignee: The Regents of the University of California
    Inventors: Daniel Tusé, Kristien Mortelmans, Leslie A. Hokama, Michael E. Selsted, Larry L. Chapoy, Michael H. Quinn
  • Patent number: 5385832
    Abstract: Substantially pure, pyrogen-free beta-1,3-glucan is produced by cultivating Euglena cells in a defined growth medium and under specified conditions that provide a cell mass comprising 70% to 90% beta-1,3-glucan on a dry weight basis, separating the cell mass from the supernatant, extracting the cell mass with methanol and chloroform, acid-washing the extracted cell mass, and washing the acid-treated material with water.
    Type: Grant
    Filed: March 22, 1993
    Date of Patent: January 31, 1995
    Assignee: SRI International
    Inventors: Daniel Tuse, Leticia Marquez, Leslie A. Hokama
  • Patent number: 5344471
    Abstract: Non-phytotoxic roots coating compositions comprising a polymer, VAM propagules, and a fungicide that selectively inhibits pathogenic fungi are provided. Also provided are methods of coating plant roots with the aforesaid composition and plants comprising roots coated with a polymer containing VAM propagules and a fungicide.In an alternative approach, the roots are first rolled in a dried polymer composition and then dipped in a suspension of VAM propagules, or attached to a film which is a dried polymer containing a spore suspension.
    Type: Grant
    Filed: November 7, 1989
    Date of Patent: September 6, 1994
    Assignee: SRI International
    Inventors: Daniel Tuse, Leslie A. Hokama, Carrie R. Foss, Jacqueline A. Tefft
  • Patent number: 5262381
    Abstract: Methods and compositions for effecting plant root infection with microorganisms, especially vesicular arbuscular mycorrhizal (VAM) fungi are disclosed. The method relies on a root baiting concept whereby the roots of a plant are caused to grow towards and/or through a material which contains an inoculum of the microorganism. Typically bead-like materials are produced which are comprised of (1) a bait material for which roots have a natural affinity; (2) an inoculum of a microorganism which can infect plant roots and improve their growth and/or health; and (3) a carrier material that supports and localizes the bait and the inoculum. The bait may be water or another suitable material such as a plant growth regulator and the carrier is typically a non-phytotoxic crosslinked polymer especially a water absorbing polymer. The compositions are placed in the vicinity of the plant roots. The bait draws the roots towards the composition to permit infection of the roots with the microorganism.
    Type: Grant
    Filed: April 8, 1993
    Date of Patent: November 16, 1993
    Assignee: Osaka Gas Co. Ltd.
    Inventors: Daniel Tuse, Leslie Hokama, Jacqueline Tefft, Gamin Wang
  • Patent number: 5084386
    Abstract: Substantially pure, pyrogen-free beta-1,3-glucan is produced by cultivating Euglena cells in a defined growth medium and under specified conditions that provide a cell mass comprising 70% to 90% beta-1,3-glucan on a dry weight basis, separating the cell mass from the super-natant, extracting the cell mass with methanol and chloroform, acid-washing the extracted cell mass, and washing the acid-treated material with water.
    Type: Grant
    Filed: March 31, 1989
    Date of Patent: January 28, 1992
    Assignee: SRI International
    Inventors: Daniel Tuse, Leticia Marquez, Leslie A. Hokama