Abstract: Aspects of the subject disclosure may include, for example, identifying positioning information associated with a wireless communication device, determining a current location of the wireless communication device based on the positioning information, detecting a location change based on the current location of the wireless communication device, and responsive to the detection of the location change, sending a location change notification to a location management entity. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, identifying positioning information associated with a wireless communication device, determining a current location of the wireless communication device based on the positioning information, detecting a location change based on the current location of the wireless communication device, and responsive to the detection of the location change, sending a location change notification to a location management entity. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, identifying positioning information associated with a wireless communication device, determining a current location of the wireless communication device based on the positioning information, detecting a location change based on the current location of the wireless communication device, and responsive to the detection of the location change, sending a location change notification to a location management entity. Other embodiments are disclosed.

Abstract: Systems and methods for displaying gene- and/or protein-related data with respect to chromosome maps at locations identifying relevant positioning of the genes with which the gene- and/or protein related data are associated. Multiple experiments may be plotted onto the display adjacent one or more chromosome maps. Automatic extraction of genomic location, based on accession numbers or other unique identifiers and cross connection with expression data is provided. Statistical assessments of correlations between expression and genome localization may be performed. Zooming capabilities, thumbnail/fullview toggling, browsability and linked data may be included as features of the visualization systems described.

Abstract: Apparatus and methods consistent with certain principles related to the present invention include a first channel, where a fluid flows through the first channel, where the first channel comprises an upstream region, a tagging region downstream of the upstream region, where at least one analyte is tagged when the fluid flows through the tagging region, a capture region downstream of the tagging region, where at least one tagged analyte is captured when the fluid flows through the capture region. A second channel communicating the upstream region of the first channel with the first channel intermediate the tagging region and capture regions, where a portion of the fluid flows through the second channel and subsequently flows into the capture region of the first channel, and where the fluid flowing through the tagging region flows into the capture region before the portion of the fluid flowing through the second channel flows into the capture region of the first channel.

Abstract: An apparatus for enhancing the collection of optical signals comprises a waveguide, which comprises a structure in a channel adapted for the flow of assay fluid. In one embodiment, fluorophore is coupled to a surface of the structure, where the fluorophore has a receptor for an analyte (ligand) in the assay fluid and the structure is adapted to transmit optical signals from the fluorophore to a detector that is adapted to detect optical signals from the fluorophore coupled to the waveguide.

Abstract: An apparatus for enhancing the collection of optical signals comprises a waveguide, which comprises a structure in a channel adapted for the flow of assay fluid. In one embodiment, fluorophore is coupled to a surface of the structure, where the fluorophore has a receptor for an analyte (ligand) in the assay fluid and the structure is adapted to transmit optical signals from the fluorophore to a detector that is adapted to detect optical signals from the fluorophore coupled to the waveguide.

Abstract: Methods for amplifying RNA from genomic DNA are provided. In the subject methods, a promoter-primer having a primer domain linked to an RNA polymerase promoter domain is first annealed to genomic DNA. The primer domain of the resultant annealed promoter-primer/genomic DNA complex is then extended to produce a double-stranded DNA molecule that has an RNA polymerase promoter domain. The resultant double-stranded DNA molecule is then transcribed into RNA product, e.g., labeled RNA product, using an RNA polymerase that is able to transcribe through the gap between the 5? terminus of the promoter domain and the 3? side of the genomic template. The subject methods find use a variety of different applications in which the preparation of amplified amounts of RNA from a genomic template is desired, where the amplification may be linear or geometric and may amplify the entire genome or only a select portion thereof. Also provided are kits for practicing the subject methods.

Abstract: Patient specific array-based assays are provided. A feature of the subject patient specific array-based assays is that they include a step of interrogating a set of array features that have been previously identified by a general array-based assay to be relevant to a specific disease and condition of the subject being assayed. Also provided are methods of producing the subject patient specific array-based assays, as well as compositions and kits for use in practicing the subject assays.

Abstract: Systems and methods for optimizing polymer analysis are provided. One such system includes a polymer analysis system having a polymer control system. The polymer analysis system is operative to: apply a set of conditions to a sample being analyzed by the polymer array, the set of conditions correspond to at least one characteristic of the polymer array; analyze the at least one characteristic using the polymer control system; and generate polymer array data.

Abstract: An apparatus and method for separating and identifying chemical moieties. The apparatus employs a microarray device coupled to a nanopore system. The apparatus both separates and identifies target molecules without the requirement of extraneous tags or fluorescent markers. Methods for using the apparatus are also disclosed.

Abstract: A method of using a chemical array unit having a chemical array with probes at multiple feature locations. A request for test may be read, which test uses a sub-array of the array. A pattern of the sub-array may be retrieved from a memory using the test request, which memory carries a pattern for the sub-array which is retrievable with the different test request. Also, a method of reading a chemical array unit which has been exposed to a sample, and feature locations of which have been rendered incapable of providing signal data representative of binding of a sample component. Further methods, apparatus, and computer program products are provided.

Abstract: An apparatus and method for separating and identifying chemical moieties. The apparatus employs a micro array device coupled to a detector such as a mass spectrometer system. The apparatus both separates and identifies target molecules without the requirement of extraneous tags or fluorescent markers. Methods for using the apparatus are also disclosed.

Abstract: Array-based clinical assays and compositions for use in practicing the same are provided. A feature of the subject array-based clinical assays is that they include a sample quality evaluation step that is independent from the clinical assay step of the assays, where the sample quality evaluation step may be performed in a number of different ways. Also provided are compositions, devices and kits for use in practicing the subject methods.

Abstract: Systems and methods for displaying gene- and/or protein-related data with respect to chromosome maps at locations identifying relevant positioning of the genes with which the gene- and/or protein related data are associated. Multiple experiments may be plotted onto the display adjacent one or more chromosome maps. Automatic extraction of genomic location, based on accession numbers or other unique identifiers and cross connection with expression data is provided. Statistical assessments of correlations between expression and genome localization may be performed. Zooming capabilities, thumbnail/fullview toggling, browsability and linked data may be included as features of the visualization systems described.

Abstract: Embodiments of the invention provide a method for detecting the arrival of a fluid at or near a thermal sensor. A method includes obtaining a signal from the thermal sensor prior to arrival of the fluid, obtaining another signal during arrival of the fluid, and relating the two signals to indicate the arrival of the fluid. Devices for application of the method are also described.

Abstract: A device for puncturing the skin of a patient. The device includes first and second protrusions, each protrusion puncturing the skin when pressed against the skin. The first and second protrusions are arranged such that the first protrusion punctures the skin at a location less than a predetermined distance from the second protrusion. The distance is chosen to be less than the discriminatable distance between distinct pain perception points in the patient, such that the patient perceives a single puncture when the first and second protrusions puncture the skin. In one embodiment of the invention, the device includes a base lip that applies a lateral force to the skin when the base lip is pressed against the skin. In this embodiment, the protrusions are pressed into the skin as the base lip is pressed against the skin.

Abstract: An apparatus for enhancing the collection of optical signals comprises a waveguide, which comprises a structure in a channel adapted for the flow of assay fluid. In one embodiment, fluorophore is coupled to a surface of the structure, where the fluorophore has a receptor for an analyte (ligand) in the assay fluid and the structure is adapted to transmit optical signals from the fluorophore to a detector that is adapted to detect optical signals from the fluorophore coupled to the waveguide.

Abstract: Apparatus and methods consistent with certain principles related to the present invention include a first channel, where a fluid flows through the first channel, where the first channel comprises an upstream region, a tagging region downstream of the upstream region, where at least one analyte is tagged when the fluid flows through the tagging region, a capture region downstream of the tagging region, where at least one tagged analyte is captured when the fluid flows through the capture region. A second channel communicating the upstream region of the first channel with the first channel intermediate the tagging region and capture regions, where a portion of the fluid flows through the second channel and subsequently flows into the capture region of the first channel, and where the fluid flowing through the tagging region flows into the capture region before the portion of the fluid flowing through the second channel flows into the capture region of the first channel.

Abstract: A method and apparatus comprising a companion cartridge containing a reagent storage system, a calibration fluid system, an assay element storage system, a carrier fluid system, and a waste retrieval system connected to a sensing cartridge to conduct chemical analysis. The companion cartridge can be adapted for assays related to blood chemistry, hematology, immuno-diagnostics, and DNA testing.