Patents by Inventor Leslie Benet

Leslie Benet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy
    Publication number: 20060002966
    Abstract: Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.
    Type: Application
    Filed: August 18, 2005
    Publication date: January 5, 2006
    Inventors: Giovanni Pauletti, James Liu, Leslie Benet, Wolfgang Ritschel
  • Method for increasing bioavailability of orally administered pharmaceutical compounds
    Patent number: 6004927
    Abstract: A method for increasing bioavailability of an orally administered hydrophobic pharmaceutical compound, which comprises orally administering the pharmaceutical compound to a mammal in need of treatment with the compound concurrently with a bioenhancer comprising an inhibitor of a cytochrome P450 3A enzyme or an inhibitor of P-glycoprotein-mediated membrane transport, the bioenhancer being present in sufficient amount to provide bioavailability of the compound in the presence of the bioenhancer greater than the bioavailability of the compound in the absence of the bioenhancer.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 21, 1999
    Assignee: Regents of the University of California
    Inventors: Leslie Benet, Chi Yuan Wu
  • Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
    Patent number: 5567592
    Abstract: A screening method for the identification of bioenhancers that increase the bioavailability of an orally administered pharmaceutical compound through the inhibition of P-glycoprotein transport activity in the gut of a mammal is disclosed. These compounds increase the systemic availability of a pharmaceutical compound when administered prior to, or concurrently with, that compound.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: October 22, 1996
    Assignee: Regents of the University of California
    Inventors: Leslie Benet, Chi Y. Wu