Abstract: An intraocular implant (IOI) includes a lens structure with variable optical power, a sensor that detects an optical accommodation response, a rechargeable power storage device, a recharging interface, a wireless communication interface, and a controller. The controller can receive information from the sensor indicating an optical accommodation response, control the lens structure to vary the variable optical power based on the information received from the sensor, control the recharging interface to recharge the rechargeable power storage device, and further control the recharging interface to receive power for operation of the IOI, and transmit and receive information through the wireless communication interface.

Abstract: Via a pulse generator, a trigger signal is generated. The trigger signal indicates one or more stimulation pulses are about to be delivered, or is being delivered, to a patient. The trigger signal is sent to a measurement instrument. Via the pulse generator, the one or more stimulation pulses are generated. The one or more stimulation pulses are delivered to the patient. With the measurement instrument and in response to the trigger signal, one or more action potentials are measured. The one or more action potentials are produced by the patient in response to the one or more stimulation pulses.

Abstract: A medical device includes telemetry circuitry configured to receive programming instructions. The medical device also includes stimulation circuitry configured to generate a plurality of electrical pulses in response to the programming instructions to provide an electrical stimulation therapy for a patient. The stimulation circuitry includes a voltage converter, a multiplexor, and a stimulation driver. At least one of the voltage converter, the multiplexer, or the stimulation driver is selectively enabled and disabled during or between the electrical pulses to reduce power consumption of the medical device.

Abstract: An intraocular implant (IOI) includes a lens structure with variable optical power, a sensor that detects an optical accommodation response, a rechargeable power storage device, a recharging interface, a wireless communication interface, and a controller. The controller can receive information from the sensor indicating an optical accommodation response, control the lens structure to vary the variable optical power based on the information received from the sensor, control the recharging interface to recharge the rechargeable power storage device, and further control the recharging interface to receive power for operation of the IOI, and transmit and receive information through the wireless communication interface.

Abstract: Via a pulse generator, a trigger signal is generated. The trigger signal indicates one or more stimulation pulses are about to be delivered, or is being delivered, to a patient. The trigger signal is sent to a measurement instrument. Via the pulse generator, the one or more stimulation pulses are generated. The one or more stimulation pulses are delivered to the patient. With the measurement instrument and in response to the trigger signal, one or more action potentials are measured. The one or more action potentials are produced by the patient in response to the one or more stimulation pulses.

Abstract: A method of identifying a location for applying a stimulation therapy to treat a patient includes stimulating a first body region of the patient transcutaneously via a stimulus generator. The body region contains a first portion of a nerve that has an elongate shape. In response to the stimulating, action potentials received from a second portion of the nerve are monitored over a period of time. The second portion of the nerve is in a second body region of the patient that is located remotely from the first body region. Based on the monitoring, an optimized location of the second portion of the nerve is determined for applying the stimulation therapy to treat the first body region.

Abstract: A medical device includes telemetry circuitry configured to receive programming instructions. The medical device also includes stimulation circuitry configured to generate a plurality of electrical pulses in response to the programming instructions to provide an electrical stimulation therapy for a patient. The stimulation circuitry includes a voltage converter, a multiplexor, and a stimulation driver. At least one of the voltage converter, the multiplexer, or the stimulation driver is selectively enabled and disabled during or between the electrical pulses to reduce power consumption of the medical device.

Abstract: A medical device for providing a stimulation therapy includes stimulation circuitry configured to provide a plurality of electrical pulses to be delivered to a patient. The stimulation circuitry contains a microcontroller configured to generate the electrical pulses. Each electrical pulse includes a primary phase, an interphase after the primary phase, and a recovery phase after the primary phase. Consecutive electrical pulses are separated by a standby period. The microcontroller is configured to operate in an active mode during at least one of: the primary phase and the interphase. The microcontroller is configured to operate in a power-conservation mode during a substantial majority of the standby period. The microcontroller consumes substantially less power when operating in the power-conservation mode than in the active mode.

Abstract: Electrical stimulation is applied to a patient at least in part via a pulse generator. A motor fiber component of an action potential that is evoked in response to the electrical stimulation is measured. A sensory fiber component of the action potential is also measured. A relationship between the motor fiber component and the sensory fiber component is determined. For example, a ratio between the sensory fiber component and the motor fiber component may be calculated, or the absolute sizes of the sensory fiber component and the motor fiber component may be compared. Based on the determined relationship between the motor and sensory fiber components, a paresthesia of the patient is estimated.

Abstract: A patient is detected to be in a first posture state. In response to the patient being detected to be in the first posture state, a first electrical stimulation therapy is applied to a body region of the patient by a pulse generator implanted in the patient. The patient is detected to be in a second posture state. In response to the patient being detected to be in the second posture state that is different from the first posture state, a second electrical stimulation therapy is applied to the body region of the patient by the pulse generator. The second electrical stimulation therapy is different from the first electrical stimulation therapy.

Abstract: Electrical stimulation is applied to a patient at least in part via a pulse generator. A motor fiber component of an action potential that is evoked in response to the electrical stimulation is measured. A sensory fiber component of the action potential is also measured. A relationship between the motor fiber component and the sensory fiber component is determined. For example, a ratio between the sensory fiber component and the motor fiber component may be calculated, or the absolute sizes of the sensory fiber component and the motor fiber component may be compared. Based on the determined relationship between the motor and sensory fiber components, a paresthesia of the patient is estimated.

Abstract: A method of establishing a stimulation treatment protocol includes delivering electrical stimulation to a nerve site of the patient. The electrical stimulation is delivered using a stimulation configuration with respect to one or more of the following: activation of a subset of a plurality of electrodes on a lead, electrode polarity for the activated electrodes, stimulation pulse width, and stimulation pulse amplitude. An action potential evoked from the nerve site in response to the electrical stimulation is measured. The action potential includes a sensory fiber contribution and a motor fiber contribution. Both the sensory fiber contribution and the motor fiber contribution are measured. The delivering and the measuring are repeated for a plurality of cycles. Each cycle is performed using a different stimulation configuration.

Abstract: A patient is detected to be in a first posture state. In response to the patient being detected to be in the first posture state, a first electrical stimulation therapy is applied to a body region of the patient by a pulse generator implanted in the patient. The patient is detected to be in a second posture state. In response to the patient being detected to be in the second posture state that is different from the first posture state, a second electrical stimulation therapy is applied to the body region of the patient by the pulse generator. The second electrical stimulation therapy is different from the first electrical stimulation therapy.

Abstract: The present disclosure involves a medical system. The medical system an implantable lead configured to deliver an electrical stimulation therapy for a patient. The lead includes an elongate lead body that is configured to be coupled to a pulse generator that generates electrical stimulations pulses as part of the electrical stimulation therapy. The lead also includes a paddle coupled to the lead body. The paddle contains a plurality of electrodes that are each configured to deliver the electrical stimulation pulses to the patient. The plurality of electrodes is arranged into at least three columns that each include a respective subset of the electrodes. The plurality of electrodes each includes a unique centerline, wherein the centerlines extend in directions transverse to the columns.

Abstract: A method of providing stimulation therapy to a patient includes performing first and second calibration processes in first and second patient posture states, respectively. The first and second calibration processes respectively associates a sensation experienced by a patient, in the respective patient posture states, with first and second amounts of an evoked potential, respectively, and also with first and second values of a stimulation parameter to achieve the first and second amounts of evoked potential, respectively. Thereafter, a current patient posture state is detected. If the current patient posture state is detected as the first patient posture state, stimulation therapy is applied to the patient using the first value of the stimulation parameter as an initial value. If the current patient posture state is detected as the second patient posture state, stimulation therapy is applied to the patient using the second value of the stimulation parameter as the initial value.

Abstract: A medical device for providing a stimulation therapy includes stimulation circuitry configured to provide a plurality of electrical pulses to be delivered to a patient. The stimulation circuitry contains a microcontroller configured to generate the electrical pulses. Each electrical pulse includes a primary phase, an interphase after the primary phase, and a recovery phase after the primary phase. Consecutive electrical pulses are separated by a standby period. The microcontroller is configured to operate in an active mode during at least one of: the primary phase and the interphase. The microcontroller is configured to operate in a power-conservation mode during a substantial majority of the standby period. The microcontroller consumes substantially less power when operating in the power-conservation mode than in the active mode.

Abstract: A method of identifying a location for applying a stimulation therapy to treat a patient includes stimulating a first body region of the patient transcutaneously via a stimulus generator. The body region contains a first portion of a nerve that has an elongate shape. In response to the stimulating, action potentials received from a second portion of the nerve are monitored over a period of time. The second portion of the nerve is in a second body region of the patient that is located remotely from the first body region. Based on the monitoring, an optimized location of the second portion of the nerve is determined for applying the stimulation therapy to treat the first body region.

Abstract: The present disclosure involves a medical system. The medical system an implantable lead configured to deliver an electrical stimulation therapy for a patient. The lead includes an elongate lead body that is configured to be coupled to a pulse generator that generates electrical stimulations pulses as part of the electrical stimulation therapy. The lead also includes a paddle coupled to the lead body. The paddle contains a plurality of electrodes that are each configured to deliver the electrical stimulation pulses to the patient. The plurality of electrodes is arranged into at least three columns that each include a respective subset of the electrodes. The plurality of electrodes each includes a unique centerline, wherein the centerlines extend in directions transverse to the columns.

Abstract: A method of providing stimulation therapy to a patient includes performing first and second calibration processes in first and second patient posture states, respectively. The first and second calibration processes respectively associates a sensation experienced by a patient, in the respective patient posture states, with first and second amounts of an evoked potential, respectively, and also with first and second values of a stimulation parameter to achieve the first and second amounts of evoked potential, respectively. Thereafter, a current patient posture state is detected. If the current patient posture state is detected as the first patient posture state, stimulation therapy is applied to the patient using the first value of the stimulation parameter as an initial value. If the current patient posture state is detected as the second patient posture state, stimulation therapy is applied to the patient using the second value of the stimulation parameter as the initial value.

Abstract: An implantable medical device, e.g., an implantable pulse generator, having a non-metal sealed housing and method of making same. An exemplary embodiment of the device includes a replenishable power source, coupling electronic components configured to generate a pulse signal to the replenishable power source, and an inorganic coating covering the electronic components and the power source to seal, preferably hermetically, the electronic components and the power source from a body environment.