Patents by Inventor Leslie Harold Smith

Leslie Harold Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ethanolamine derivatives having .beta.-adrenergic blocking activity
    Patent number: 4117157
    Abstract: Novel 1-aryl-2-amidoalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed ia 1-phenyl-2-(1,1-dimethyl-2-phenylacetamidoethyl)aminoethanol.
    Type: Grant
    Filed: April 14, 1977
    Date of Patent: September 26, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith
  • Alkanolamine derivatives
    Patent number: 4115409
    Abstract: Novel 1-aryloxy-3-carbamoylalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(2-cyanophenoxy)-3-.beta.-(N-2-furfurylcarbamoyl)ethylamino-2-propanol.
    Type: Grant
    Filed: November 26, 1976
    Date of Patent: September 19, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventors: Michael Stewart Large, Leslie Harold Smith
  • Amide derivatives
    Patent number: 4086357
    Abstract: Novel 1-aryl-2-carbamoylalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(4-methanesulphonamidophenyl)-2-(.beta.-N-2-furfurylcarbamoylethylamino) ethanol.
    Type: Grant
    Filed: November 26, 1976
    Date of Patent: April 25, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventors: Michael Stewart Large, Leslie Harold Smith
  • Ethanolamine derivatives
    Patent number: 4085221
    Abstract: Novel 1-aryl-2-amidoalkylaminoethanol derivatives which contain at least one heterocyclic substituent, processes for their manufacture, pharmaceutical compositions containing them and a method of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 2-.beta.-(2-methylthiazol-4-ylacetamido)ethylamino-1-.beta.-naphthylethano l.
    Type: Grant
    Filed: November 26, 1976
    Date of Patent: April 18, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith
  • Alkanolamine derivatives
    Patent number: 4083992
    Abstract: Novel 1-aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-phenoxy-3-.beta.-isobutyramidoethylamino-2-propanol.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: April 11, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith
  • Phenoxy-alkanolamine derivatives
    Patent number: 4041075
    Abstract: Novel 1-amidoaryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-o-(N-.beta.-hydroxyethylcarbamoylmethoxy)-phenoxy-3-.beta.-isobutyramido ethylamino-2-propanol.
    Type: Grant
    Filed: March 4, 1976
    Date of Patent: August 9, 1977
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith
  • Alkanolamine derivatives
    Patent number: 4034106
    Abstract: Novel 1-heterocyclyloxy- or 1-aryloxy-3-amido-alkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(4-indolyloxy)-3-.beta.-isobutyramidoethylamino-2-propanol.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: July 5, 1977
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith
  • Ethanolamine derivatives having .beta.-adrenergic blocking activity
    Patent number: 4034112
    Abstract: Novel 1-aryl-2-amidoalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-phenyl-2-(1,1-dimethyl-2-phenylacetamidoethyl)aminoethanol.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: July 5, 1977
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith
  • Alkanolamine derivatives
    Patent number: 4010189
    Abstract: Novel 1-aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-phenoxy-3-.beta.-isobutyramidoethylamino-2-propanol.
    Type: Grant
    Filed: August 26, 1975
    Date of Patent: March 1, 1977
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith
  • Alkanolamine derivatives
    Patent number: 3959369
    Abstract: Novel 1-amidoaryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-o-(N-.beta.-hydroxyethylcarbamoylmethoxy)-phenoxy-3-.beta.-isobutyramido ethylamino-2-propanol.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: May 25, 1976
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith
  • Nitrogen-containing compounds
    Patent number: 3944611
    Abstract: Novel 1-aryl-2-amidoalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-phenyl-2-(1,1-dimethyl-2-phenylacetamidoethyl)amino-ethanol.
    Type: Grant
    Filed: June 13, 1974
    Date of Patent: March 16, 1976
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie Harold Smith