Patents by Inventor Leslie J. Raffel

Leslie J. Raffel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
    Patent number: 8178294
    Abstract: Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a human subject for certain biological conditions, which may be related to coronary artery disease.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: May 15, 2012
    Assignee: Cedars-Sinai Medical Center
    Inventors: Kent D. Taylor, Jerome I. Rotter, Huiying Yang, Willa A. Hsueh, Xiuqing Guo, Leslie J. Raffel, Mark O. Goodarzi, Yii-Der Ida Chen
  • Method of haplotype-based genetic analysis for determining risk for developing insulin resistance and coronary artery disease
    Patent number: 7141373
    Abstract: Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a Mexican-American human subject for developing insulin resistance and methods of detecting a lower than normal risk in a Mexican-American human subject for developing insulin resistance or coronary artery disease.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: November 28, 2006
    Assignees: Cedars-Sinai Medical Center, The Regents of the University of California
    Inventors: Kent D. Taylor, Jerome I. Rotter, Huiying Yang, Willa A. Hsueh, Xiuqing Guo, Leslie J. Raffel, Mark O. Goodarzi
  • Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
    Publication number: 20040076988
    Abstract: Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a Mexican-American human subject for developing insulin resistance and methods of detecting a lower than normal risk in a Mexican-American human subject for developing insulin resistance or coronary artery disease.
    Type: Application
    Filed: June 16, 2003
    Publication date: April 22, 2004
    Inventors: Kent D. Taylor, Jerome I. Rotter, Huiying Yang, Willa A. Hsueh, Xiuqing Guo, Leslie J. Raffel, Mark O. Goodarzi