Patents by Inventor Leslie Jean Holsinger

Leslie Jean Holsinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrazines that inhibit protease cathepsin S and HCV replication
    Patent number: 8106059
    Abstract: The present invention is directed to compounds of formula I, below, that have the dual property of acting as cathepsin S inhibitors and of inhibiting HCV replication. Such compounds are therefore useful in treating disease states that include hepatitis C, Alzheimer's disease, and autoimmune disorders. The present invention is also directed to pharmaceutical compositions containing these compounds, and processes for preparing the compounds.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: January 31, 2012
    Assignee: ViroBay, Inc.
    Inventors: Leslie Jean Holsinger, Kyle Elrod, John O. Link, Michael Graupe, In Jong Kim
  • COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION
    Publication number: 20090270415
    Abstract: The present invention is directed to compounds that have the dual property of acting as cathepsin S inhibitors and of inhibiting HCV replication. Such compounds are therefore useful in treating disease states that include hepatitis C, Alzheimer's disease, and autoimmune disorders. The present invention is also directed to pharmaceutical compositions containing these compounds, and processes for preparing the compounds.
    Type: Application
    Filed: October 22, 2008
    Publication date: October 29, 2009
    Applicant: ViroBay, Inc.
    Inventors: Leslie Jean Holsinger, Kyle Elrod, John O. Link, Michael Graupe, In Jong Kim